A5054139492- Gut microbiota and health
- Gastrointestinal motility and disorders
- Bacterial Infections and Vaccines
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Cellular transport and secretion
- Effects of Radiation Exposure
- Biochemical and Structural Characterization
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- Reproductive tract infections research
- Neutropenia and Cancer Infections
- Genomics and Phylogenetic Studies
- Nutritional Studies and Diet
- Vibrio bacteria research studies
Genetic Analysis (Norway)
2013-2023
University of Oslo
2001-2014
Imperial College London
2004
University of Bristol
2004
Infectious Disease Research Institute
2001
National Institute of Allergy and Infectious Diseases
2001
Utrecht University
2001
National Institutes of Health
2001
Summary Background Dysbiosis is associated with many diseases, including irritable bowel syndrome ( IBS ), inflammatory diseases IBD obesity and diabetes. Potential clinical impact of imbalance in the intestinal microbiota suggests need for new standardised diagnostic methods to facilitate microbiome profiling. Aim To develop validate a novel test using faecal samples profile identify characterise dysbiosis. Methods Fifty‐four DNA probes targeting ≥300 bacteria on different taxonomic levels...
Abstract Background A major bottleneck in the use of metagenome sequencing for human gut microbiome studies has been lack a comprehensive genome collection to be used as reference database. Several recent efforts have made re-construct genomes from data, resulting huge increase number relevant genomes. In this work, we aimed create most prevalent healthy prokaryotic genomes, database, including both MAGs and ordinary RefSeq Results We screened > 5,700 metagenomes containment 490,000...
Several major bacterial pathogens and related commensal species colonizing the human mucosa express phosphocholine (PC) at their cell surfaces. PC appears to impact host–microbe biology by serving as a ligand for both C-reactive protein receptor platelet-activating factor. Type IV pili of Neisseria gonorrhoeae (Ng) meningitidis , filamentous structures critical colonization hosts, are known react variably with monoclonal antibodies recognizing epitope. However, structural basis this...
Type IV pili (Tfp) of Neisseria gonorrhoeae , the Gram-negative etiologic agent gonorrhea, facilitate colonization human host. Tfp are assumed to play a key role in initial adherence epithelial cells by virtue associated adhesin protein PilC. To examine structural and functional basis for more detail, we identified potential genes encoding polypeptides sharing similarities PilE (the subunit) within N. genome sequence database. We show here that fiber subunit-like protein, termed PilV, is...
The effect of dietary fibres on intestinal barrier function has not been well studied, especially in the elderly. We aimed to investigate potential oat β-glucan and wheat arabinoxylan strengthen counteract acute non-steroid anti-inflammatory drug (indomethacin)-induced hyperpermeability A general population elderly subjects (≥65 years, n = 49) was randomised a daily supplementation (12g/day) β-glucan, or placebo (maltodextrin) for six weeks. primary outcome change indomethacin-induced...
Butyrate and propionate represent two of three main short-chain fatty acids produced by the intestinal microbiota. In healthy populations, their levels are reportedly equimolar, whereas a deviation in ratio has been observed various diseased cohorts. Monitoring such represents valuable metric; however, it remains challenge to adopt acid detection techniques clinical settings because volatile nature these acids. Here we aimed estimate information indirectly through novel, simple quantitative...
Abstract Background A major bottleneck in the use of metagenome sequencing for human gut microbiome studies has been lack a comprehensive genome collection to be used as reference database. Several recent efforts have made re-construct genomes from data, resulting huge increase number relevant genomes. In this work, we aimed create most prevalent healthy prokaryotic genomes, database, including both MAGs and ordinary RefSeq Results We screened > 5,700 metagenomes containment 490,000...
The PilE pilin subunit protein of the gonococcal Type IV pilus (Tfp) colonization factor undergoes multisite, covalent modification with zwitterionic phospho-form phosphoethanolamine (PE). In a mutant lacking pilin-like PilV however, is modified mixture PE and phosphocholine (PC). Moreover, intrastrain variation PC levels have been observed in backgrounds that constitutively express PptA (the transferase A) required for both modification. molecular basis underlying microheterogeneity these...
Science S81Conclusions: These data show a strong correlation of inflammatory responses between the colitis and radiationinduced models GI injury, with common TNF-mediated, neutrophilic component in colon jejunum, respectively.Further studies will investigate time course tissue differences.The efficacy AVX-470m both highlights central role TNF tract inflammation, supports therapeutic potential an oral anti-TNF antibody disease.
Poster presentations to a labeled end of an amplified gene.T-RFLP is established technique for analysing bacterial species in faecal samples.Methods: This was quantitative analysis with major focus on evaluating biomarker based intestinal microbiota.The subjects were 69 UC patients together 80 relatives as controls.Twenty-three had active (group I) and 46 quiescent II).The latter included 17 mild inflammation the large intestine IIa), 29 without IIb).The patients' consanguineous III, n =...