A5102813834- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Cardiac Health and Mental Health
- Cardiovascular Function and Risk Factors
- Sarcoidosis and Beryllium Toxicity Research
- Coronary Artery Anomalies
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Mechanical Circulatory Support Devices
- Immune cells in cancer
- Chemotherapy-induced organ toxicity mitigation
- Ultrasound in Clinical Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacy and Medical Practices
- Immune responses and vaccinations
- Chemotherapy-induced cardiotoxicity and mitigation
- Connexins and lens biology
- Advanced X-ray and CT Imaging
- Cardiac Structural Anomalies and Repair
The University of Tokyo
2018-2024
Sakakibara Hospital
2024
University of Tokyo Hospital
2017-2020
Jichi Medical University
2013-2019
Jichi Medical University Saitama Medical Center
2014-2019
Osaka Rosai Hospital
2011
Shirasagi Hospital
1997
Abstract Cardiac arrhythmias are a primary contributor to sudden cardiac death, major unmet medical need. Because right ventricular (RV) dysfunction increases the risk for we examined responses RV stress in mice. Among immune cells accumulated after pressure overload-induced by pulmonary artery banding, interfering with macrophages caused death from severe arrhythmias. We show that crucially maintain impulse conduction facilitating myocardial intercellular communication through gap...
Patients with heart failure (HF) often experience repeated acute decompensation and develop comorbidities such as chronic kidney disease frailty syndrome. Although this suggests pathological interaction among comorbidities, the mechanisms linking them are poorly understood. Here, we identified alterations in hematopoietic stem cells (HSCs) a critical driver of recurrent HF associated comorbidities. Bone marrow transplantation from HF-experienced mice resulted spontaneous cardiac dysfunction...
Proper resolution of inflammation is vital for repair and restoration homeostasis after tissue damage, its dysregulation underlies various noncommunicable diseases, such as cardiovascular metabolic diseases. Macrophages play diverse roles throughout initial inflammation, resolution, repair. Differential reprogramming reportedly required induction support the macrophage activation states. Here we show that a long noncoding RNA (lncRNA), lncFAO , contributes to in mice by promoting fatty acid...
Abstract The technique of catheter ablation has been improved within the past few decades, especially by three-dimensional (3D) mapping system. 3D system reduced radiation exposure but procedures still require fluoroscopy. Our previous study showed safety and efficacy based on intracardiac echogram combined with CARTOSOUND/CARTO3 system, however fluoroscopy use for an average 16 min is required this procedure. present was aimed to reduce zero establish a free method goal utilizing it in...
Spontaneous coronary artery dissection (SCAD) is considered to be a rare cause of acute syndrome, especially recurrent or multivessel dissection. We present here the case 51 year-old man who had and SCAD. In initial event, distal segment right was spontaneously dissected, which confirmed by angiography (CAG), intracoronary ultrasound (IVUS), multidetector computed tomography (MDCT). second left dissected. The IVUS MDCT, although CAG did not show stenosis, occlusion, in artery. These findings...
Abstract Vascular toxicity is one of serious complications following cisplatin‐based chemotherapy. This case suggests that cisplatin has a potential risk delayed occurrence vasospastic angina. It important to perform careful history taking including discontinued drugs for differential diagnosis chest pain.
Cardiac involvement in systemic sarcoidosis sometimes provokes life-threatening ventricular tachyarrhythmia. Steroid administration is one of the fundamental anti-arrhythmia therapies. For an indication steroid therapy, a definitive diagnosis required.1) However, cases that are clearly suspected cardiac based on their clinical courses do not meet current diagnostic criteria and result loss appropriate opportunity to perform therapy.Here we report case was diagnosed as by incidental biopsy...
Background:Periprocedural anticoagulation is important in catheter ablation (CA) of atrial fibrillation (AF) and there increasing evidence that uninterrupted vitamin K antagonist (VKA) therapy superior to interrupted strategies. Since the emergence direct oral anticoagulants (DOACs), numerous studies have shown promising results for their use However, further are needed define efficacy safety performing AF with factor XA inhibitors or thrombin inhibitors.
Abstract Convolutional neural networks (CNNs) applied to electrocardiograms (ECGs) have been showing utility for detecting left ventricular (LV) dysfunction 1 . Although early detection of reduced LV ejection fraction (rEF) could improve handling heart failure (HF) with rEF (HFrEF), it is not sufficient detect HF preserved EF (HFpEF). Here we developed a CNN algorithm classify the severity based on single-lead ECG data, irrespective EF. We trained using data and classification from 7,865...
Clinical predictors for pacemaker-induced cardiomyopathy (PICM) (e.g., a wide QRS duration and left bundle branch block at baseline) have been reported. However, factors involved in the development of PICM patients with preserved ventricular ejection fraction (LVEF) remain unknown. This study aimed to determine risk LVEF. The data 113 (average age: 71.3 years; men: 54.9%) who had echocardiography before after pacemaker implantation (PMI) among 465 undergoing dual-chamber PMI were...
Background:In patients undergoing catheter ablation (CA) for atrial fibrillation (AF), the use of uninterrupted direct oral anticoagulants (DOACs) is current protocol. This study evaluated bleeding complications following 4 DOACs in CA AF without any change dosing regimen. Moreover, we assessed differences between once- and twice-daily DOAC who continued on
A cardiac resynchronization therapy defibrillator (CRT-D) (Medtronic Inc. Protecta XT) was implanted in a 67-year-old man who had sarcoidosis with extremely low function. He ventricular tachycardia which controlled by catheter ablation, medication and pacing. The programmed mode DDI, lower rate 90 beats/minute, paced AV delay 150 ms, the noncompetitive atrial pacing (NCAP) function as 300 ms.After his admission for pneumonia heart failure, we changed DDI to DDD because he tachycardia, led...
A 41-year-old man developed cardiac arrest. resting 12-lead electrocardiogram showed a delta wave, suggestive of preexcitation syndrome. An electrophysiological test revealed the existence inducible atrial fibrillation and fasciculoventricular accessory pathway (FVAP). After these examinations, idiopathic ventricular arrhythmia was suspected. For evaluating concealed Brugada syndrome, pilsicainide administered, which diminished wave no Brugada-like observed. Ventricular double...