A5060620693- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- ECG Monitoring and Analysis
- Heat shock proteins research
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Drug Solubulity and Delivery Systems
- Advanced Thermodynamic Systems and Engines
- Coronary Artery Anomalies
- Spaceflight effects on biology
- thermodynamics and calorimetric analyses
- Cardiovascular Health and Disease Prevention
- Cardiac Fibrosis and Remodeling
- Sarcoidosis and Beryllium Toxicity Research
- Immune responses and vaccinations
- Evacuation and Crowd Dynamics
- Connexins and lens biology
- IgG4-Related and Inflammatory Diseases
- Toxin Mechanisms and Immunotoxins
- Hormonal Regulation and Hypertension
Kanto Central Hospital
2025
The University of Tokyo
2011-2024
Tokyo City University
2023
University of Tokyo Hospital
2011-2020
Shizuoka University
2016-2018
Hoshi University
2018
Bunkyo University
2015
Toho University Medical Center Sakura Hospital
2015
Toho University
2015
Fukuoka University
2013
Abstract Cardiac arrhythmias are a primary contributor to sudden cardiac death, major unmet medical need. Because right ventricular (RV) dysfunction increases the risk for we examined responses RV stress in mice. Among immune cells accumulated after pressure overload-induced by pulmonary artery banding, interfering with macrophages caused death from severe arrhythmias. We show that crucially maintain impulse conduction facilitating myocardial intercellular communication through gap...
Patients with heart failure (HF) often experience repeated acute decompensation and develop comorbidities such as chronic kidney disease frailty syndrome. Although this suggests pathological interaction among comorbidities, the mechanisms linking them are poorly understood. Here, we identified alterations in hematopoietic stem cells (HSCs) a critical driver of recurrent HF associated comorbidities. Bone marrow transplantation from HF-experienced mice resulted spontaneous cardiac dysfunction...
Proper resolution of inflammation is vital for repair and restoration homeostasis after tissue damage, its dysregulation underlies various noncommunicable diseases, such as cardiovascular metabolic diseases. Macrophages play diverse roles throughout initial inflammation, resolution, repair. Differential reprogramming reportedly required induction support the macrophage activation states. Here we show that a long noncoding RNA (lncRNA), lncFAO , contributes to in mice by promoting fatty acid...
<title>Abstract</title> Pulmonary vein isolation (PVI) is now a cornerstone of treatment for atrial fibrillation. The unipolar voltage map analysis could determine the thick wall areas pulmonary vein. However, benefit utilizing in routine PVI unknown. Twenty-seven cases received conventional and 21 unipolar-voltage-map-guided ablation. Total RF points were decreased from 97 to 70 average unipolar-guided group. 6 months recurrence rate was 33.3% group 14.3% map-guided
Background Elevated left atrial (LA) pressure predisposes individuals to the initiation and persistence of fibrillation (AF), LA hypertension is associated with AF recurrence after catheter ablation (CA). However, exact frequency factors are unknown, its noninvasive estimation challenging. This study aimed investigate prevalence determinants in patients who underwent first CA. Methods Results We examined 183 conventional speckle‐tracking echocardiography before CA assess size, reservoir...
Emerging evidence suggests a pathophysiological link between obesity and atrial fibrillation (AF). However, the contribution of body fat distribution to left (LA) remodeling its reversibility remain unclear in nonobese AF patients.
Abstract Risk factors for pacemaker-induced cardiomyopathy (PICM) have been previously reported, including a high burden of right ventricular pacing, lower left ejection fraction, wide QRS duration, and bundle branch block before pacemaker implantation (PMI). However, predicting the development PICM remains challenging. This study aimed to use convolutional neural network (CNN) model, based on clinical findings PMI, predict PICM. Out total 561 patients with dual-chamber 165 (mean age 71.6...
Ventricular tachycardia commonly arises within the intraventricular septum and successful catheter ablation of septal might be enhanced by transseptal electrode placement. We have evaluated safety a procedure. Arrhythmogenicity histology were examined after high-energy capacitor discharges delivered to an intracavitary cathode-anode pair placed on opposite sides interventricular in pentobarbital-anesthetized dogs. After two 200 or 100 J proved lethal, paired 30 50 (10 dogs) single discharge...
Abstract The technique of catheter ablation has been improved within the past few decades, especially by three-dimensional (3D) mapping system. 3D system reduced radiation exposure but procedures still require fluoroscopy. Our previous study showed safety and efficacy based on intracardiac echogram combined with CARTOSOUND/CARTO3 system, however fluoroscopy use for an average 16 min is required this procedure. present was aimed to reduce zero establish a free method goal utilizing it in...
To investigate the exact prevalence of glucose metabolism disorders, and their impact on left atrial (LA) remodelling reversibility in patients with fibrillation (AF).We examined 204 consecutive AF who underwent first catheter ablation (CA). Oral tolerance test was used to evaluate disorders 157 without known diabetes mellitus (DM). Echocardiography performed before 6 months after CA. identified abnormal 86 [11 newly diagnosed DM, 74 impaired (IGT) 1 fasting (IFG)]. Ultimately, 65.2% had...
Sanguinarine is an isoquinoline alkaloid produced by Papaveraceae plants. Because sanguinarine has antimicrobial activity, it believed to be related the plants' chemical defense systems. However, its action against plants not been well understood. A previous study reported that among 12 alkaloids, was only compound which enhanced heat tolerance in Arabidopsis. Here we performed a promoter assay using shock protein gene (HSP17.6C-CI) of Arabidopsis assess induction responses alkaloids....
Background:Periprocedural anticoagulation is important in catheter ablation (CA) of atrial fibrillation (AF) and there increasing evidence that uninterrupted vitamin K antagonist (VKA) therapy superior to interrupted strategies. Since the emergence direct oral anticoagulants (DOACs), numerous studies have shown promising results for their use However, further are needed define efficacy safety performing AF with factor XA inhibitors or thrombin inhibitors.
The aim of the present study was to investigate influence polysorbate 60 (Tween 60) on development morin-loaded nanoemulsions improve oral bioavailability morin. Nanoemulsions were prepared using Tween and polyvinyl alcohol (PVA) as emulsifiers, medium chain triglycerides (MCT) lipid base. Low-saponification-degree PVA (LL-810) also added stabilize dispersed droplets. MCT-LL810 nanoemulsion containing LL-810 with a reduced amount 60. However, area under blood concentration-time curve (AUC)...
Abstract Convolutional neural networks (CNNs) applied to electrocardiograms (ECGs) have been showing utility for detecting left ventricular (LV) dysfunction 1 . Although early detection of reduced LV ejection fraction (rEF) could improve handling heart failure (HF) with rEF (HFrEF), it is not sufficient detect HF preserved EF (HFpEF). Here we developed a CNN algorithm classify the severity based on single-lead ECG data, irrespective EF. We trained using data and classification from 7,865...
Background: Left atrial (LA) functional remodeling plays an essential role in the pathophysiological mechanisms of fibrillation (AF). LA reservoir strain (LARS) measured by speckle-tracking echocardiography (STE) exhibits acceptable predictive value for recurrent arrhythmia patients with paroxysmal AF, while its performance persistent AF remains inconclusive. Recently, reserve, a novel concept mechanics response to acute-volume overload, is drawing attention. Research Questions: Are LARS and...
Patients who have undergone cardiac transplantation are occasionally complicated by the development of a coronary artery fistula. It has been reported that majority fistulas in post-heart transplant setting communicate with right ventricle. Moreover, most had favorable prognosis and were rarely associated hemodynamic disorder. In contrast, present report describes case progressive fistula drained into pulmonary Japanese male underwent size-mismatch orthotopic from white donor. The gradually...
Clinical predictors for pacemaker-induced cardiomyopathy (PICM) (e.g., a wide QRS duration and left bundle branch block at baseline) have been reported. However, factors involved in the development of PICM patients with preserved ventricular ejection fraction (LVEF) remain unknown. This study aimed to determine risk LVEF. The data 113 (average age: 71.3 years; men: 54.9%) who had echocardiography before after pacemaker implantation (PMI) among 465 undergoing dual-chamber PMI were...
Atrial fibrillation (AF) progression is closely related to heart failure occurrence, and catheter ablation carries a beneficial effect for prevention. Recently, particular attention has been given left atrial (LA) function functional reserve in the pathogenesis linking AF failure, although its significance reversibility not well studied.