A5103099149- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Medical Imaging Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Health, Medicine and Society
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Lung Cancer Treatments and Mutations
- CNS Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Clinical Reasoning and Diagnostic Skills
- Epigenetics and DNA Methylation
- Syphilis Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Clinical Laboratory Practices and Quality Control
- Radiomics and Machine Learning in Medical Imaging
- Biomedical Text Mining and Ontologies
- Polyomavirus and related diseases
Université de Caen Normandie
2016-2025
Centre Hospitalier Universitaire de Caen
2016-2025
Centre François Baclesse
2019
Centre Hospitalier Universitaire Amiens-Picardie
2006-2014
Université de Picardie Jules Verne
2013
Hôpital Necker-Enfants Malades
2013
Hôpital Nord
2009
Mastocytosis is a rare and chronic disease with phenotypes ranging from indolent to severe. Prognosis for this variable very few biomarkers predict evolution or outcome are currently known. We have performed comprehensive screening in our large cohort of mastocytosis patients mutations previously found other myeloid diseases that could serve as prognostic indicators. KIT, SRSF2-P95 TET2 were by far the most frequent, detected 81%, 24% 21% patients, respectively. Where mutation both...
Background/Objectives: Non-Hodgkin lymphoma (NHL) represents 63% of all hematological malignancies in France, with diffuse large B-cell (DLBCL) and follicular (FL) being the two most frequent forms. With improvement therapeutics, issue health-related quality life (HRQoL) is becoming increasingly crucial for these patients. The aim was to compare HRQoL NHL survivors that general French population identify factors associated survivors. Methods: We conducted a population-based study among...
B-chronic lymphocytic leukemia (B-CLL), the most common human leukemia, is characterized by predominantly non-dividing malignant mature CD5+ B lymphocytes with an apoptosis defect. Various microenvironmental stimuli confer a growth advantage on these leukemic cells and extend their survival in vivo. Nevertheless, when cultured vitro, CLL B-cells rapidly die from apoptosis. Certain cytokines may capacity of vitro individual anti-apoptotic effects several have been reported. The potential...
The contribution of genetic factors to the severity adult haemophagocytic lymphohistiocytosis (HLHa) remains unclear. To assess a potential link between HLHa outcomes and HLH-related gene variants. Clinical characteristics 130 patients with (age≥18 years old “HScore”≥169) genotype eight genes (LYST, PRF1, UNC13-D, STX11, STXBP2, RAB27A, XIAP SAP) were collected. A total 34 variants found in only six selected based on their frequency criteria predicted impair protein function. Severity was...
Mast cell leukemia (MCL) is a rare and aggressive disease with poor prognosis short survival time. D816V c-KIT mutation the most frequent molecular abnormality plays crucial role in pathogenesis development of disease. Thus, comprehensive diagnostic investigations studies should be carefully carried out to facilitate therapeutic choice. A MCL patient’s case phenotypic genotypic characteristics described review major clinical biological approaches MCL.
Summary Mastocytosis is an acquired orphan disease characterized by the abnormal accumulation of mast cells responsible for organ failure and systemic symptoms. Cytoreductive drugs have been shown to be effective, but rarely resulted in complete or long‐term remission. We report two patients with advanced mastocytosis (SM) who were treated successfully thalidomide, given at maximal tolerated dosage. B C‐findings as well clinical symptoms rapidly improved. After a follow‐up more than 1 year,...
Background . To better describe the clinical, biological, and outcome of non-Hodgkin's lymphoma (NHL) with, at initial presentation, bone marrow fibrosis (MF). Patients Methods From January 2001 to 2007, 16 eligible patients with NHL MF were retrieved from Pathology Department University hospital Amiens. Median age was 62 years (range 16–74) a sex ratio male/female 3. Results is associated all types predominantly B-cell phenotype it seems be more low-grade NHL. B-symptoms are frequent...
(1) To perform a comprehensive analysis of the time elapsed between last G-CSF injection and PET/CT examination on biodistribution 18F-FDG, with emphasis liver, spleen, bone marrow uptake, (2) to investigate whether an inversion liver spleen ratio affects Deauville scoring.Retrospectively included were 74 consecutive diffuse large B cell lymphoma (DLBCL) patients referred for baseline interim examinations receiving immunochemotherapy various regimens. A evaluation considering metabolic...
Absolute count of circulating monocytes has been proposed as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, monocyte nomenclature includes various subsets with pro-, anti-inflammatory, or suppressive functions, and their clinical relevance DLBCL poorly explored. Herein, we broadly assessed heterogeneity 91 patients. Classical- (cMO, CD14 pos CD16 neg ) intermediate- (iMO, accumulated peripheral blood exhibited inflammatory phenotype. On the opposite,...
ZAP-70 and CD38 expression can identify B-cell chronic lymphocytic leukemia with an inferior clinical outcome. Many groups have investigated the meaning of these two proteins correlation bad prognosis in B-CLL. But nobody has relation between multidrug resistance mediated by Pgp overexpression (MDR1) ZAP-70/CD38 coexpression. Forty-one untreated stage A patients, either ZAP-70+CD38+ or ZAP-70−CD38−, were tested to determine MDR1 status. was observed 41% CLL 37% ZAP-70−CD38−. The difference...
Aims To propose recommendations related to the presentation, content and formulation of full blood count analysis reports. Methods Strong professional agreement among a group experts from French-Speaking Cellular Haematology Group (GFHC) was obtained. Results The following two proposals emerged consensus: (1) stratification comments into three parts upon discovery an anomaly in cell (2) selection and/or redefinition terms recommended for designating types found normal pathological peripheral...
In DLBCL, the Deauville scoring system (DS) is standard for PET/CT response assessment. An alternative system, based on semi-quantitative change in standardized uptake values, namely ΔSUVmax, has been reported to be more objective than DS. We aimed compare ΔSUVmax and DS risk stratification of DLBCL patients end-of-treatment (EoT) PET. 108 consecutive were included. 2-year EFS Kaplan-Meier survival analyses Cox regression models performed. was significantly different between favorable (favΔ...
Abstract Absolute count of circulating monocytes has been proposed as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, monocyte nomenclature includes various subsets with pro-, anti-inflammatory, or suppressive functions, and their clinical relevance DLBCL poorly explored. Herein, we broadly assessed heterogeneity 91 patients. Classical- (cMO, CD14 pos CD16 neg ) intermediate- (iMO, accumulated peripheral blood exhibited inflammatory phenotype. On the...