A5101836957- Carbohydrate Chemistry and Synthesis
- Advanced Photocatalysis Techniques
- Sulfur-Based Synthesis Techniques
- Glycosylation and Glycoproteins Research
- Antimicrobial agents and applications
- Electrocatalysts for Energy Conversion
- Catalytic C–H Functionalization Methods
- Antimicrobial Peptides and Activities
- Electrochemical Analysis and Applications
- Synthesis and Catalytic Reactions
- Nitric Oxide and Endothelin Effects
- Legume Nitrogen Fixing Symbiosis
- Bacterial Genetics and Biotechnology
- 2D Materials and Applications
- Biopolymer Synthesis and Applications
- Cancer therapeutics and mechanisms
- Oxidative Organic Chemistry Reactions
- Perovskite Materials and Applications
- Synthesis and biological activity
- Advanced Nanomaterials in Catalysis
- Polydiacetylene-based materials and applications
- Metalloenzymes and iron-sulfur proteins
- Synthetic Organic Chemistry Methods
- Antimicrobial Resistance in Staphylococcus
- Advanced battery technologies research
Nanyang Technological University
2017-2024
Oriental Yuhong (China)
2023
Yunnan University
2020-2021
Kunming University
2021
Zero to Three
2020
Zhejiang University of Technology
2013
Ping An (China)
1994
An efficient glycosylation reaction utilizing a meticulously designed thioglycoside has been developed. The well-established protocol was demonstrated in the total synthesis of TD139 and one-pot assembly E. coli O33 antigen tetrasaccharide.
Peptidoglycan (PG), an essential exoskeletal polymer in bacteria, is a well-known antibiotic target. PG polymerization requires the action of bacterial transglycosylases (TGases), which couple incoming glycosyl acceptor to donor. Interfering with TGase activity can interrupt assembly. Existing inhibitors like moenomycin and Lipid II analogues always occupy active sites; other strategies interfere proper elongation have not been widely exploited. Inspired by natural 1,6-anhydro-MurNAc termini...
Most synthetic antimicrobial polymers are not biodegradable, thus limiting their potential for large-scale applications in personal care disinfection and environmental contaminations. Poly(ε-caprolactone) (PCL) is known to be both biodegradable biocompatible, representing an ideal candidate biopolymer applications. Here we successfully grafted alkylimidazolium (Im) onto PCL mimic the cationic properties of peptides. The poly(ε-caprolactone)-graft-butylimidazolium had only moderate MICs (32...
We report an effective strategy to in situ construct the oxime-Ni2+ complex unit on polymeric carbon nitride (PCN) as a molecular catalyst for highly efficient hydrogen evolution reaction (HER). The PCN was functionalized with oxime groups that allowed immobilizing Ni2+ form units surface uniform distribution. electrochemical characterizations reveal these can effectively capture photogenerated electrons from and serve active catalytic sites proton reduction. Notably, enriched showed even...
Abstract In light of the important biological activities and widespread applications organic disulfides, dithiocarbamates, xanthates, thiocarbamates thiocarbonates, continual persuit efficient methods for their synthesis remains crucial. Traditionally, preparation such compounds heavily relied on intricate multi‐step syntheses use highly prefunctionalized starting materials. Over past two decades, direct sulfuration C−H bonds has evolved into a straightforward, atom‐ step‐economical method...
ACu(OTf) 2 /Fe(OTf) 3 -promoted facile and stereoselective synthesis of 2,3-unsaturated glycosides through Ferrier rearrangement rationally designed glycals with C3-CCBz. The dual roles the metal catalysts in reaction are explored DFT.
In this work, we have successfully constructed a cobalt-oxo (CoIII4 O4 ) cubane complex on polymeric carbon nitride (PCN) through pyridine linkage. The covalently grafted CoIII4 units were uniformly distributed the PCN surface. product exhibited greatly enhanced photocatalytic activities for water oxidation under visible-light irradiation. Further characterizations and spectroscopic analyses revealed that could effectively capture photogenerated holes from excited PCN, lower overpotential of...
Organochalcogen compounds are prevalent in numerous natural products, pharmaceuticals, agrochemicals, polymers, biological molecules and synthetic intermediates. Direct chalcogenation of C-H bonds has evolved as a step- atom-economical method for the synthesis chalcogen-bearing compounds. Nevertheless, direct severely lags behind C-C, C-N C-O bond formations. Moreover, compared with monochalcogenation, reports selective mono-/dichalcogenation exclusive dichalcogenation relatively scarce. The...
Herein, oxadiazabicyclooctenone is successfully developed as a versatile monomer for the construction of new pH-sensitive polymers by ROMP.
A convenient and simple procedure is described for the oxidation of benzylic C–H moiety alkylarenes to give corresponding aryl ketones, using <i>tert</i>-butyl hydroperoxide and<i> m</i>-chloroperoxybenzoic acid in presence a catalytic amount hypervalent iodine reagent, (diacetoxyiodo)benzene. The reactions typically occur good yields 2,2,2-trifluoroethanol as solvent at room temperature.
A mild method to access functionalized 2-iminothiazolines in a facile and efficient manner has been developed.
Abstract We present the fabrication of core‐shell‐satellite Au@SiO 2 ‐Pt nanostructures and demonstrate that LSPR excitation core Au nanoparticle can induce plasmon coupling effect to initiate photocatalytic hydrogen generation from decomposition formic acid. Further studies suggest induces a strong local electric field between Pt nanoparticles on SiO shell, which enables creation hot electrons non‐plasmonic‐active participate evolution reaction surface. In addition, small shell thickness is...
Here we report a strategy for carbonyl addition with unactivated alkenes using an organic photocatalyst on both aldehyde and ketone substrates. This protocol grants us good alternative to the traditional Barbier-Grignard allylation that exhibits poor functional group tolerance. With this method stoichiometric use of metals can be avoided, high atom economy achieved fewer by-products are generated.
Abstract The worsening situation of global drug resistance is urgently demanding for novel antimicrobial agents. Considerable efforts have been concentrated on developing new antibacterial therapies with mode actions, exerting no selective pressure bacterial mutation, and minimizing toxicity to host cells. In this context, active targeting can greatly contribute selectivity between pathogens mammalian cells in which carbohydrates, playing important roles numerous biological processes, be...
Emerging drug resistance is creating an urgent demand for new antimicrobial therapeutics. Besides the development of conventional antibiotics, agents with novel mechanisms have attracted great attention, such as peptides and polymers. Interactions between carbohydrates proteins on microbes are believed to be first step pathogenesis. Thus, considerable efforts been made carbohydrate-containing molecules in research. Recent progress glycosylated macromolecules applications has discussed...