A5101409583- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Temporomandibular Joint Disorders
- Alzheimer's disease research and treatments
- Lipid metabolism and biosynthesis
- Neurobiology of Language and Bilingualism
- Bone Tissue Engineering Materials
- Adipose Tissue and Metabolism
- dental development and anomalies
- Neurological Disorders and Treatments
- Oral microbiology and periodontitis research
- Voice and Speech Disorders
- Cerebrovascular and Carotid Artery Diseases
- Spatial Neglect and Hemispheric Dysfunction
- Frailty in Older Adults
- Functional Brain Connectivity Studies
- Oropharyngeal Anatomy and Pathologies
- Facial Nerve Paralysis Treatment and Research
- Memory and Neural Mechanisms
- Migration, Ethnicity, and Economy
- Endoplasmic Reticulum Stress and Disease
- Bone and Dental Protein Studies
- Fuel Cells and Related Materials
- Orthodontics and Dentofacial Orthopedics
- Dysphagia Assessment and Management
Foundation Osaka City Museum Association
2024
Tohoku University
2014-2023
Tohoku Medical Megabank Organization
2023
Toyota Motor Corporation (Switzerland)
2023
Ryukoku University
2021
Mitsubishi Electric (United States)
2021
Osaka University
2006-2020
Tokyo Medical and Dental University
1993-2019
Chiba Institute of Technology
2019
Japan Radioisotope Association
2018
Phosphoglucose isomerase (PGI) is a multifunctional enzyme that functions in glucose metabolism as glycolytic catalyzing an interconversion between and fructose inside the cell, while it acts cytokine outside with properties include autocrine motility factor (AMF)-regulating tumor cell motility. Overexpression of AMF/PGI induces epithelial-to-mesenchymal transition enhanced malignancy. Recent studies have revealed silencing resulted mesenchymal-to-epithelial (MET) human lung fibrosarcoma...
To examine the relationship between incidence of dementia and chronic kidney disease (CKD).Longitudinal data analyses.Baseline follow-up from Osaki-Tajiri Project.The Tajiri Project prevalence study in 1998 involved 497 community-dwelling, older men women (346 with Clinical Dementia Rating score (CDR) 0 (healthy), 119 a CDR 0.5 (questionable dementia), 32 1 or greater (dementia)). Two hundred fifty-four participants who were reclassified as converters (n=28) nonconverters (n=230) to 2003...
l-2-Hydroxyglutaric aciduria (L-2-HGA) is a rare inherited neurometabolic disorder.1 The disease characterized clinically by cerebellar ataxia, intellectual decline, leukoencephalopathy, and elevation of l-2-hydroxyglutaric acid (L-2-HG) lysine in plasma CSF.2 metabolic pathway L-2-HG humans poorly characterized, there no effective treatment for L-2-HGA. We report an adult case L-2-HGA that was successfully treated with flavin adenine dinucleotide sodium (FAD) levocarnitine chloride. ###...
<i>Background:</i> The borderline condition between health and dementia, defined as Clinical Dementia Rating (CDR) 0.5, should be detected for the possible prediction of dementia. Since CDR requires information from collateral sources, it is difficult to rate people living alone. aim develop a set tests without detecting 0.5 converters <i>Methods:</i> 625 participants were selected community; 412 0 (healthy), 168 (defined here mild cognitive impairment; MCI), 45 1+...
Deficits in the cholinergic system are pronounced dementia with Lewy bodies (DLB) and more severe patients visual hallucinations (VHs). The aim is to identify occipital glucose metabolism patterns by positron emission tomography (PET) changes following donepezil treatment. 13 DLB VHs were enrolled study. After first FDG-PET study, 5 mg/day was administered orally, a second PET study performed 3 months later. administration, disappeared completely 6 patients, studies revealed significantly...
Cholinesterase inhibitors (ChEIs) such as donepezil have the effect of delaying progression Alzheimer's disease (AD), but their on life expectancy is unclear. We analyzed influence after onset AD, together with effects antipsychotic drugs and residency in a nursing home. All outpatients at Tajiri Clinic from 1999–2012 available medical records death certificates were included retrospective analysis. The entry criteria dementia diagnosis based DSM-IV AD using NINCDS-ADRDA criteria; treatment...
Although tooth loss and periodontitis have been considered risk factors of Alzheimer disease, recent longitudinal researches not found a significant association with hippocampal atrophy. Therefore, this study aimed to clarify between the number teeth present (NTP) atrophy dependent on severity in late middle-aged older adult population.This included community-dwelling individuals aged 55 years or who had no cognitive decline undergone brain MRI oral systemic data collection twice at 4-year...
ABSTRACT Background: In dementia patients, dietary intake problems may occur despite the absence of swallowing problems. We investigated cognitive functions on food and taste in Alzheimer's disease (AD) vascular (VaD) patients. Methods: Participants included 15 healthy controls (HC), 30 AD 20 VaD Food Cognition Test : Replicas three popular foods Japan with no odors were presented visually to each participant, instruction respond name food. materials subsequently ask whether they these...
Triglyceride deposit cardiomyovasculopathy (TGCV) is an intractable cardiovascular disease for which a specific treatment urgently required. In TGCV, adipose triglyceride lipase (ATGL) deficiency results in the abnormal intracellular metabolism of long-chain fatty acid (LCFA) leads to TG deposition. Medium-chain triglycerides have been used as important functional food various human diseases. To address potential activities tricaprin, medium-chain triglyceride, on cardiac dysfunctions we...
Although bone morphogenetic protein-2 (BMP-2) has received considerable attention because of its strong osteoinductivity, the clinical application BMP-2 is limited due to degradation and deactivation under physiological conditions. Negatively charged heparin known form polyelectrolyte complexes with prevent enhance osteoinduction capability BMP-2. Herein, we report sulfonated polyrotaxanes (S-PRX) composed α-cyclodextrin threaded onto a linear polymer for protection through complex...
Abstract Adenosine plays several roles in the kidney mediated by specific receptors A 1 , 2 and possibly 3 . We studied localization of adenosine receptor mRNA rat nephron segments using reverse transcription polymerase chain reaction (RT-PCR). The male Sprague-Dawley rats (6 to 8 weeks old) were microdissected. Total RNA was prepared acid-guanidinium–phenol–chloroform method used following RT-PCR assay. Because PCR primers spanned no intron, samples reacted absence RT as controls for...
We investigated how sleep disturbance is correlated with brain lesions, cognitive impairment and decreased daily activity (ADL). Two hundred four chronically ill patients including vascular dementia were classified into eight groups based on function, ADL grades of PVL (periventricular lucency) as shown by computerized tomography. Visual monitoring the sleep/wake state was performed hourly for 14 consecutive days daytime hours nighttime determined detected disturbances in pattern. Whether...
Background and Objectives: Cerebral MRIs of normal aging Alzheimer's disease (AD) frequently reveal corpus callosum (CC) atrophy, white matter hyperintensity (WMH), hippocampal atrophy. However, their relationship between these findings cognitive function has not been fully studied. We investigated the CC WHM, together with frontal executive dysfunction in both AD. Method: examined 170 randomly selected residents from a designated community: 99 Clinical Dementia Rating (CDR) 0 (healthy,...
Abstract Bone reconstruction is a challenging issue in the regeneration of surgically removed bone and disease‐related defects. Although morphogenetic protein‐2 (BMP‐2) has received considerable attention as inducer, high dose BMP‐2 typically required due to its short life‐time under vivo conditions. We have proposed method enhance osteogenetic differentiation ability vitro that based on supramolecular polyelectrolyte complexation with sulfonated polyrotaxanes (PRXs) consisting sulfopropyl...
Background Capric acid (FA10:0, decanoic acid) is a medium-chain fatty abundant in tropical oils such as coconut oil, whereas small amounts are present milk of goat, cow, and human. Orally ingested FA10:0 transported to the liver quickly burnt within it. Only few reports available for concentrations human plasma. Methods Fasting (n = 5, male/female 3/2, age 31 ± 9.3 years old) non-fasting 106, 44/62, 21.9 3.2 blood samples were collected from apparently healthy Japanese volunteers. The total...
Background: Several follow-up [18F]fluorodeoxy glucose (FDG)-positron emission tomography (PET) studies have been performed in patients with mild cognitive impairment, but none examined subjects a Clinical Dementia Rating (CDR) of 0.5. Therefore, we used FDG-PET to investigate whether baseline metabolism (CMRglc) CDR 0.5 converters dementia showed changes consistent early Alzheimer's disease (AD).Methods: Based on our earlier study, which refer as Prevalence Study 1998, were able examine 14...