A5106232968- Nanoparticles: synthesis and applications
- Air Quality and Health Impacts
- Nanoparticle-Based Drug Delivery
- Antimicrobial Resistance in Staphylococcus
- Natural product bioactivities and synthesis
- Graphene and Nanomaterials Applications
- Heavy Metal Exposure and Toxicity
- Nanocluster Synthesis and Applications
- Nanopore and Nanochannel Transport Studies
- Hedgehog Signaling Pathway Studies
- Bacterial biofilms and quorum sensing
- Sulfur Compounds in Biology
- Semiconductor materials and devices
- Essential Oils and Antimicrobial Activity
- Advancements in Photolithography Techniques
- Trace Elements in Health
- Curcumin's Biomedical Applications
- Copper Interconnects and Reliability
- Nanofabrication and Lithography Techniques
- Bacteriophages and microbial interactions
- Advanced Nanomaterials in Catalysis
- Neural and Behavioral Psychology Studies
- Biochemical and Structural Characterization
- Quantum Dots Synthesis And Properties
- Clostridium difficile and Clostridium perfringens research
Université de Lorraine
2016-2025
Institut Jean Lamour
2017-2025
Centre National de la Recherche Scientifique
2014-2024
Université Claude Bernard Lyon 1
2024
École Normale Supérieure de Lyon
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Institut des Matériaux Jean Rouxel
2018-2020
Nantes Université
2018
Cibles thérapeutiques, formulation et expertise préclinique du médicament
2014-2017
Délégation Centre-Est
2015
Background Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, also stem cell maintenance tissue regeneration adults. Aberrant Shh pathway activation is involved the development of many tumors, one most affected steps found these tumors regulation receptor Smoothened by Patched. In present work, we investigated Patched activity mechanism which inhibits Smoothened. Methodology/Principal Findings Using well-known Shh-responding line mouse...
Curcumin, a neuroprotective agent with promising therapeutic approach has poor brain bioavailability. Herein, we demonstrate that curcumin-encapsulated poly(lactide-co-glycolide) (PLGA) 50:50 nanoparticles (NPs-Cur 50:50) are able to prevent the phosphorylation of Akt and Tau proteins in SK-N-SH cells induced by H2O2 display higher anti-inflammatory antioxidant activities than free curcumin. PLGA can various physicochemical degradation characteristics for controlled drug release applications...
The aims of the current study were to prepare chitosan nanoparticles (CNPs) and evaluate its protective role alone or in combination with quercetin (Q) against AFB1-induce cytotoxicity rats. Male Sprague-Dawley rats divided into 12 groups treated orally for 4 weeks as follow: control group, group AFB1 (80 μg/kg b.w.) corn oil, low (140 mg/kg high (280 dose CNPs, Q (50 b.w.), plus CNPs and/or at two tested doses. results also revealed that administration resulted a significant increase serum...
2,2’-(Ethylenedioxy)bis(ethylamine)-functionalized graphene quantum dots (GQDs) were prepared under mild conditions from oxide (GO) via oxidative fragmentation. The as-prepared GQDs have an average diameter of ca. 4 nm, possess good colloidal stability, and emit strong green-yellow light with a photoluminescence (PL) yield 22% upon excitation at 375 nm. We also demonstrated that the exhibit high photostability PL intensity is poorly affected while tuning pH 1 to 8. Finally, can be used...
Asteraceae species Tanacetum balsamita L. (costmary) is renowned for its traditional usage as an aromatic, carminative and tonic plant. This work aimed at in-depth study of the phytochemical in vitro biological profilings methanol–aqueous extracts from costmary leaves, flower heads roots. An UHPLC-HRMS analysis revealed more than 100 secondary metabolites including 24 acylquinic acids, 43 flavonoid glycosides, aglycones methoxylated derivatives together with 15 phenolic acids glycosides. For...
Abstract Human exposure to airborne carbon nanotubes (CNT) is increasing because of their applications in different sectors; therefore, they constitute a biological hazard. Consequently, developing studies on CNT toxicity become necessity. CNTs can have properties term length, size and charge. Here, we compared the cellular effect multiwall (MWCNTs) single wall (SWCNTs). MWCNTs consist multiple layers graphene, while SWCNTs are monolayers. The effects were evaluated by water‐soluble...
Abstract The toxicity of heavy metals present in binary semiconductor nanoparticles also known as quantum dots (QDs) has hindered their wide applications hence the advent non-toxic ternary dots. These new group have been shown to possess some therapeutic action against cancer cell lines but not significant enough be referred an ideal agent. In this report, we address problem by conjugating red emitting CuInS/ZnS QDs a 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin -photosensitizer for...
Cicerbita alpina (L.) Wallr. is a perennial herbaceous plant in the tribe Cichorieae (Lactuceae), Asteraceae family, distributed mountainous regions Europe. In this study, we focused on metabolite profiling and bioactivity of C. leaves flowering heads methanol-aqueous extracts. The antioxidant activity extracts, as well inhibitory potential towards selected enzymes, involving several human diseases, including metabolic syndrome (α-glucosidase, α-amylase, lipase), Alzheimer's disease,...
This work presents the graphoepitaxy of high-χ block copolymers (BCP) in standard industry-like lithography stacks and their transfer into silicon substrate The process includes conventional 193 nm photolithography, directed self-assembly polystyrene-block-polydimethylsiloxane (PS-b-PDMS) pulsed plasma etching to obtained features substrate. PS-b-PDMS has a high Flory–Huggins interaction parameter (high-χ) is capable achieving sub-10 feature sizes. photolithography stack fabricated on 300 mm...
Despite a wide production and use of zinc oxide nanoparticles (ZnONP), their toxicological study is only limited number impact at molecular level seldom addressed. Thus, we have used, as model, nanoparticle NM110 (ZnO110NP) exposure to PMA-differentiated THP-1 macrophages. The cell viability was studied the cellular using WST-1, LDH Alamar Blue® assays, well by transcriptomic analysis. Exposure cells ZnO110NP for 24 h decreased in dose-dependent manner with mean inhibitory concentrations...
Abstract On a daily basis, people are exposed to multitude of health‐hazardous airborne particulate matter with notable deposition in the fragile alveolar region lungs. Hence, there is great need for identification and prediction material‐associated diseases, currently hindered due lack in‐depth understanding causal relationships, particular between acute exposures chronic symptoms. By applying advanced microscopies omics vitro vivo systems, together silico molecular modeling, it determined...
Polymer selection and critical dimension control across the wafer are key parameters for nanoimprint lithography technique. This nanotechnology requires polymers having a low glass transition temperature Tg combined with good etch resistance. In this work, three different have been evaluated. The influence of pressing time is analyzed to clarify correlation between polymer behavior printing uniformity as function pattern density. Measurements residual thickness show that strongly correlated...
B Cl 3 based plasmas exhibit promising plasma chemistries to etch high-k materials and, in particular, HfO2, with a high selectivity over SiO2 and Si substrates. The authors report on the mechanisms involved etching of SiO2, poly-Si substrates BCl3 plasmas. X-ray photoelectron spectroscopy analyses help understanding mechanism driving between HfO2 silicon-containing ion energy plays an important role since it controls transition BCl-like deposition substrate its by ionic bombardment....
Functionalized multi-walled carbon nanotubes (MWCNT) have become the focus of increased research interest, particularly in their application as tools different areas, such biomedical field. Despite benefits associated with functionalization MWCNT, overcoming issues relating to solubility, several studies demonstrated that these functionalized nanoparticles display toxicity profiles. For this study, we aim compare NR8383 cells responses three well-characterized MWCNT varying functional...