Tissue resident mesenchymal stem cells (MSCs) are known to participate in tissue regeneration that follows cell turnover, apoptosis, or necrosis. It has been long aging impedes an organism's repair/regeneration capabilities. In order study the age associated changes, molecular characteristics of adipose derived MSCs (ASCs) from three groups healthy volunteers i.e., young, middle aged, and aged were investigated. The number multilineage differentiation potential ASCs declined with age. Aging...

Summary: Large-sized recurrent abdominal wall hernias are commonly repaired via component separation, involving the release of lateral muscles to facilitate defect closure. However, in settings without viable or superficial soft-tissue coverage, alternative methods must be considered. This case report describes a technique hernia repair using large bridging mesh for treatment large-sized incisional hernia. Two patients with at previous incision measuring 15 × 35 and 23 cm 2 underwent as...

Chiu, Ernest S. M.D.; Liu, Perry H. Baratelli, Roxanne Lee, Mark Y. Chaffin, Abigail E. Friedlander, Paul L. M.D. Author Information

Epps, Matthew T. B.A., M.Sc.; Cannon, Cliff L. M.D.; Wright, Mary J. Chaffin, Abigail E. Newsome, R. Edward Friedlander, Paul Chiu, Ernest S. M.D. Author Information

A significant number of patients undergo mastectomies and breast reconstructions every year using many surgical-based techniques to reconstruct the nipple-areolar complex (NAC). Described herein is a tissue engineering approach that may permit human NAC onlay graft during reconstruction procedures. By applying decellularization, which removal cellular components from tissue, an intact whole donor NAC, extracellular matrix (ECM) structure preserved. This creates biologically derived scaffold...

Background Ultrasound-guided regional field blocks are not widely used in outpatient plastic surgeries. The efficacy of truncal (PEC1 + SAP) has been established surgery. purpose this study was to analyze the outcomes these newer anesthetic techniques compared with traditional blind local infiltration patients undergoing breast augmentation. Methods This retrospective institutional review board-approved cohort different practices 2 surgeons at same accredited surgery center between 2018 and...

Abstract Background Tissue resident mesenchymal stem cells (MSCs) are multipotent, self-renewing known for their differentiation potential into of lineage. The ability single cell clones isolated from adipose tissue MSCs (ASCs) to differentiate hematopoietic lineage has been previously demonstrated. In the present study, we investigated if differentiated (HD) derived ASCs could productively be infected with HIV-1. Results HD were generated by differentiating clonally expanded cultures...

The effect of intratracheal administration cyclooxygenase-1 (COX-1)-modified adipose stem cells (ASCs) on monocrotaline-induced pulmonary hypertension (MCT-PH) was investigated in the rat. COX-1 gene cloned from rat intestinal cells, fused with a hemagglutanin (HA) tag, and into lentiviral vector. vector shown to enhance protein expression inhibit proliferation vascular smooth muscle without increasing apoptosis. Human ASCs transfected (ASCCOX-1) display enhanced activity while exhibiting...

Surgical management of Hurley stage III hidradenitis suppurativa (HS) typically involves the excision diseased tissue and subsequent reconstruction, potentially leading to complications or recurrence disease. This pilot case series sought evaluate a decellularised ovine forestomach matrix (OFM) extracellular (ECM) graft for soft regeneration as part surgical reconstruction HS axilla.The prospective involved six participants total eight defects. The ECM was used either dermal substitute...

Summary: Social media is beginning to eclipse practice websites and other traditional electronic marketing utilized by plastic surgeons. First, highlights are presented from the relevant literature. Next, this article presents a new case study of how, why, when, what social being used ASPS members (n = 100). Results suggest significant disconnect between surgeons highest impact platforms reported in literature such as Instagram, YouTube, Snapchat, Facebook. Plastic currently prefer focus...

Pilonidal sinus disease (PSD) is a chronic inflammatory affecting the soft tissue of sacrococcygeal region and remains challenging for clinicians to treat. The optimal treatment PSD controversial recent reports describe several different surgical approaches offering benefits. Approximately 40% initial incision drainage cases require subsequent surgery. Due high recurrence rates postoperative complications, more complex revision surgery involving flap reconstruction may be required. We...

Introduction: Concealed penis (CP) is a rare problem faced by urologists and plastic surgeons. CP occurs secondary to trauma, obesity, or infection. Surgical treatment individualized based on patient provider variables. We aim review our recent experience using meshed split-thickness skin grafting (STSG) for management.Methods: A retrospective was performed patients who underwent STSG at institution. Records were reviewed demographic, operative, postoperative Preoperative photos obtained...

Soft tissue defects, especially those involving exposed vital structures, present a reconstructive challenge because poor vascularity of such defects typically makes immediate skin grafting unviable. Where flap procedures are inappropriate or not possible, dermal matrices represent an alternative option for with denuded structures. With becoming increasingly available and technologically advanced, we evaluated ovine-derived extracellular matrix graft in the reconstruction complex soft...

The retrospective pragmatic real-world data (RWD) study compared the healing outcomes of diabetic foot ulcers (DFUs) treated with either ovine forestomach matrix (OFM) (n = 1150) or collagen/oxidised regenerated cellulose (ORC) 1072) in out-patient wound care centres. Median time to closure was significantly (P .0015) faster OFM group (14.6 ± 0.5 weeks) relative collagen/ORC (16.4 0.7). A sub-group analysis performed understand efficacy DFUs requiring longer periods treatment and showed that...

Price transparency allows patients to estimate surgical procedure costs, which can affect where they elect receive care and should theoretically result in hospitals setting lower more uniform prices. To elucidate the traditionally opaque nature of health pricing, U.S. Centers for Medicare & Medicaid Services has mandated that publicly release their pricing information. The authors sought investigate utility price plastic surgery patients, who are uniquely situated benefit because dominance...

There are more than 3 million breast cancer survivors living in the United States of which a significant number have undergone mastectomy followed by and nipple-areolar complex (NAC) reconstruction. Current strategies for NAC reconstruction dependent on nonliving or nonpermanent techniques, including tattooing, nipple prosthetics, surgical nipple-like structures. Described herein is tissue engineering approach demonstrating feasibility an allogeneic acellular graft Nonhuman primate...

Two-stage breast reconstruction with tissue expanders is one of the most common plastic surgery procedures. Acellular dermal matrix (ADM) has become popular for its ability to improve expansion parameters and aesthetics, albeit a higher complication profile. We present data that support redefining 2-stage include regardless final reconstructive modality act as bridge. Furthermore, we show cooperation ablative surgeon technical refinements ADM omission from first stage reconstruction.We...

Many of the > 3.5 million breast cancer survivors in US have undergone reconstruction following mastectomy. Patients report that nipple-areolar complex (NAC) is psychologically important, yet current techniques commonly result inadequate shape, symmetry, and nipple projection. Our team has developed an allogeneic acellular graft for NAC (dcl-NAC) designed to be easy engraft, lasting, aesthetically pleasing. Here, dcl-NAC safety host-mediated re-cellularization was assessed a 6-week study...

Hidradenitis suppurativa is a chronic inflammatory condition that presents challenging reconstructive problem for plastic surgeons.The authors performed retrospective chart review of hidradenitis patients managed with surgical excision between 2005 and 2020 at Brigham Women's Hospital Tulane University Medical Center. Operative cases associated the same hospitalization were organized into treatment episodes assessed patient demographics, operative techniques, outcomes.A total 181 patients,...

Summary: Lower extremity defects are challenging to reconstruct. The keystone perforator island flap proves useful in difficult cases. Traditionally, a handheld Doppler is used confirm vessel(s) within the but has disadvantages including low sensitivity/specificity. Surgeons can use thermal imaging localize “hot spots” on skin, corresponding perforators. FLIR ONE (FLIR Systems Inc., Wilsonville, OR) portable camera with high concordance computed tomographic angiography. In this case, when...