A5019311635- Reproductive Health and Technologies
- Epilepsy research and treatment
- Prenatal Screening and Diagnostics
- Reproductive Biology and Fertility
- Bariatric Surgery and Outcomes
- Neuroscience and Neuropharmacology Research
- Ovarian function and disorders
- Gestational Diabetes Research and Management
- Pharmacological Effects and Toxicity Studies
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Genomic variations and chromosomal abnormalities
- Advanced MRI Techniques and Applications
- Bone Tumor Diagnosis and Treatments
- Cancer Risks and Factors
- Diet and metabolism studies
- Cerebrospinal fluid and hydrocephalus
- Craniofacial Disorders and Treatments
- Facial Trauma and Fracture Management
- Renal and related cancers
- Cancer Diagnosis and Treatment
- Cleft Lip and Palate Research
- Ectopic Pregnancy Diagnosis and Management
LKH Hochsteiermark
2021-2025
Wunschbaby Institut für Kinderwunsch
2016-2025
Medical University of Vienna
2006-2021
Karolinska Institutet
2018-2021
University of Vienna
2021
Uppsala University
2020
University of Graz
2000-2020
Karolinska University Hospital
2017-2020
Central Institution for Meteorology and Geodynamics
2020
Comprehensive Cancer Center Vienna
2019
The paper aims to investigate the biological role of microRNAs secreted by preimplantation embryo into blastocoel fluid and detect a distinctive molecular signature for identifying embryos with highest implantation potential. We carried on multicenter retrospective study involving five European IVF centers. collected 112 samples from day 5 post-fertilization, cultured individually, along data blastocyst grade transfer outcomes. Using custom TLDA Array, we compared expression levels 89 miRNAs...
A history of gastric bypass surgery can influence the results OGTT recommended during pregnancy. Therefore, we compared glucose kinetics and pregnancy outcome between pregnant patients BMI-matched, lean obese controls. Medical records were used to collect data on measurements 2 h 75 g as well fetal for 304 women (n = 76 per group, matched age date delivery). Women after bariatric had lower fasting levels with lean, BMI-matched controls, showed altered postprandial kinetics, including a rise...
Summary: Purpose: Anterior callosotomy is a surgical option for the treatment of generalized tonic or atonic seizures associated with drop attacks. Besides open surgery, radiosurgical callosal disconnection using gamma knife (GK) also can be performed, but reliable data about tolerability and efficacy are sparse. Methods: Eight patients (three female, five male age range, 5 to 69 years) severe epilepsy disabling attacks underwent GK between 1993 2004. In six patients, anterior third corpus...
An early identification of the risk groups might be beneficial in reducing morbidities patients with gestational diabetes mellitus (GDM). Therefore, this study aimed to assess biochemical predictors glycemic conditions, addition fasting indices glucose disposal, predict development GDM later stage and need glucose-lowering medication.A total 574 pregnant females (103 471 normal tolerance [NGT]) were included. A metabolic characterization was performed before 15⁺⁶ weeks gestation by assessing...
Abstract Aims Dyslipidemia in pregnancy is associated with adverse outcomes as elevated triglycerides might be considered a risk factor for hyperglycemia and gestational diabetes. As only few studies have addressed the association between maternal glucose metabolism, we aimed to explore pathophysiologic associations of moderate hypertriglyceridemia metabolism pregnancy. Methods Sixty-seven pregnant women received detailed metabolic characterization at 12+0–22+6 weeks gestation by an extended...
Recently, 2 branches of the wide area synthetic biology-in vitro gametogenesis and embryo development-have gained considerable attention. Rodent induced pluripotent stem cells derived via reprogramming somatic can in be differentiated into gametes to produce fertile offspring. And even embryos with organ progenitors were generated ex utero entirely from murine cells. The use these approaches basic research, which is rightfully accompanied by an ethical discussion, will allow hitherto...
Meiotic errors during oocyte maturation are considered the major contributors to embryonic aneuploidy and failures in human IVF treatment. Various technologies have been developed screen polar bodies, blastomeres trophectoderm cells for chromosomal aberrations. Array-CGH analysis using bacterial artificial chromosome (BAC) arrays is widely applied preimplantation genetic diagnosis (PGD) single cells. Recently, an increase pregnancy rate has demonstrated array-CGH evaluate However, some...
Hypothalamic hamartomas are nonneoplastic lesions often characterized by central precocious puberty and gelastic epilepsy. Due to the delicate location surgery is unsuccessful associated with considerable risks. In presented series, Gamma Knife radiosurgery was applied. Four cases (aged between 5-13 years) who medically intractable epilepsy increasing secondary generalization, abnormal behaviour (3 cases) reported. sized 11-17 mm had been diagnosed MR imaging. Radiosurgical treatment...
There are emerging data indicating an association between PCOS (polycystic ovary syndrome) and metabolic derangements with potential impact on its clinical presentation. This study aims to evaluate the pathophysiological processes beyond particular focus carbohydrate metabolism, ectopic lipids their possible interaction. Differences two established classifications of disease should be additionally evaluated.A characterization was performed in 53 untreated patients as well 20 controls...
Ictal fear (IF) is most frequently associated with epileptic discharges from mesial temporal areas.To determine whether patients IF were more likely to become seizure free after anteromesial lobe resection compared those without and they show anteriorly pronounced metabolic changes assessed by means of multivoxel magnetic resonance spectroscopy (MRS) along the hippocampal axis.Surgical outcome was in 33 consecutive epilepsy a mean follow-up 25 months (range, 12-38 months). Proton MRS...
To investigate the impact of symptomatic and surgically confirmed endometriosis on ovarian sensitivity index (OSI) cumulative live-birth rates (LBR) using predominantly single embryo transfer (SET). Cross-sectional case-control study in a University-based ART program. Women with (N = 172), who underwent IVF/ICSI at Karolinska University Hospital were compared to controls without clinically suspected 2585). Two thousand seven hundred fifty-seven patients 8236 treatment cycles (4598 fresh 3638...
Summary: Purpose: In some patients with temporal lobe epilepsy, histopathological evaluation of resected brain tissue after surgical treatment may reveal several features indicative discrete cortical malformations. We sought to determine whether these were accompanied by hippocampal changes detectable preoperatively proton magnetic resonance (MR) spectroscopy and evaluate their relationship postoperative outcome. Methods: 25 consecutive epilepsy who scheduled for treatment, MR was performed,...
The efficacy of radiosurgery in cases mesiotemporal tumours associated with long standing epilepsy has not clearly been documented up to now. authors present a retrospective analysis 19 treated by Gamma-Knife (GKRS) for tumour epilepsy.Between 1992 and 1997 patients (12 male 7 female) mean age 31 years (5-72) tumour-induced duration 8.6 (0.9-28) were GKRS. All within the structures pathohistology proven biopsy or resective procedure revealed 15 (79%) low grade astrocytomas, 3 (16%)...