A5033088750- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Intraoperative Neuromonitoring and Anesthetic Effects
- Advanced Neuroimaging Techniques and Applications
- RNA Research and Splicing
- Brain Metastases and Treatment
- Epilepsy research and treatment
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Cell Image Analysis Techniques
- Surgical site infection prevention
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- Orthopedic Infections and Treatments
- Pharmacological Effects and Toxicity Studies
- Skin and Cellular Biology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- 14-3-3 protein interactions
- Management of metastatic bone disease
- Medical Imaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Colorectal Cancer Surgical Treatments
Tokyo Women's Medical University
2014-2025
OBJECTIVE In this study on the effectiveness and safety of photodynamic therapy (PDT) using talaporfin sodium a semiconductor laser, long-term follow-up results 11 patients with glioblastoma enrolled in authors’ previous phase II clinical trial (March 2009–2012) 19 consecutive newly diagnosed prospectively postmarket surveillance 2014–December 2016) were analyzed compared those 164 treated without PDT during same period. METHODS The main outcome measures median overall survival (OS)...
Recurrent glioblastoma (GBM) remains one of the most challenging clinical issues, with no standard treatment and effective options. To evaluate efficacy talaporfin sodium (TS) mediated photodynamic therapy (PDT) as a new for this condition, we retrospectively analyzed 70 patients who underwent surgery PDT (PDT group) recurrent GBM 38 alone (control group). The median progression-free survival (PFS) in control groups after second was 5.7 2.2 months, respectively (p = 0.0043). overall (OS)...
A unified view on recovery from supplementary motor area syndrome after glioma resection is lacking. This study retrospectively examined the relationship between function, higher brain ability to perform activities of daily living, and social reintegration extent tumor in patients who underwent tumors near area. We assigned 24 consecutive into 3 groups according depth resection: involving (A) only (5 patients); (B) cingulate gyrus (11 (C) area, gyrus, corpus callosum (8 patients). Motor...
In this report, the authors present first case of adult brainstem pilocytic astrocytoma (PA) with H3 K27M mutation. A 53-year-old man was incidentally found to have a 2.5-cm partially enhanced tumor in tectum on MRI. The enhancement lesion increased over 3 years, and gross-total removal performed via occipital transtentorial approach. resected tissue indicated PA, WHO Grade I, genetic analysis revealed However, although radiological, surgical, pathological findings all corresponded entity...
We developed a navigation system that superimposes the fractional anisotropy (FA) color map of pre-operative diffusion tensor imaging (DTI) and intraoperative magnetic resonance (MRI). The current study aimed to investigate usefulness this for neurophysiological monitoring examination under awake craniotomy during tumor removal.A total 10 glioma patients (4 with right-side tumors; 5 men women; average age, 34 years) were evaluated. Among them, was localized frontal lobe, insular cortex,...
Neurosurgery is complex surgery that requires a strategy maximizes the removal of tumors and minimizes complications; thus, safe environment during should be guaranteed. In this study, we aimed to verify safety brain using intraoperative magnetic resonance imaging (iMRI), based on surgical experience since 2000. Thus, retrospectively examined 2,018 procedures utilized iMRI performed in operating room at Tokyo Women's Medical University Hospital between March 2000 October 2019. As per our...
Abstract The patient was a 57-year-old woman. She underwent laparotomy 14 months before her ER visit because of enlarged pelvic lymph nodes during follow-up for uterine adenomyosis. pathological diagnosis adenocarcinoma adenomyosis origin, with metastasis to and FIGO classification stage 3C1. had been treated six courses TC (Paclitaxel+Carboplatin) postoperatively judged CR 2 the visit. visited due nausea dizziness, head scan revealed cerebellar tumor. admitted hospital on same day close...
Abstract BACKGROUND Glioblastoma (GBM) is a highly malignant tumor with poor prognosis despite advances in treatment. At our institution, an autologous formalin-fixed vaccine (AFTV) has been used as postoperative adjuvant therapy addition to standard temozolomide and chemoradiotherapy. We present real-world data analyze the correlation between AFTV, molecular markers, clinical outcomes newly diagnosed GBM patients. METHODS This study included 402 patients treated at institution 2005 2021....
OBJECTIVE: Intraoperative histopathological investigation plays an important role during surgery for gliomas. To facilitate the rapid characterization of resected tissue, original technique intraoperative flow cytometry (iFC) was established. The objective in this study evaluation technique's efficacy rapidly determining tumor presence surgical biopsy sample and WHO grade neoplasm. METHODS: In total, 328 separate specimens obtained resection 81 intracranial gliomas were analyzed with iFC....
Abstract Early diagnosis of glioma is great value to improve prognosis. We focused on serum vimentin levels as a useful biomarker for preoperative diagnosis. The aim this study was determine whether in patients with are significantly higher than those healthy adult volunteer and the level associated overall survival (OS) glioblastoma (GBM). This included 52 consecutive newly diagnosed control group 13 volunteers. measured blood samples obtained from preoperatively group. Furthermore, we...
Abstract BACKGROUND Glioblastoma has the worst prognosis of brain tumors. Evidence for improving by maximal tumor removal is being established, and in recent years, new treatments such as photodynamic therapy (PDT, 2014 Japan), TTF (2018) have been approved, treatment results are improving. In principle, our facility performs maximum using intraoperative MRI (iMRI) follow standard chemoradiation. Intraoperative PDT autologous vaccine (AFTV) will be given to desired patients. We...
In the 2016 WHO classification, genetic information was introduced in pathological diagnosis of gliomas, and correlation between molecular subtype prognosis has been shown. High extent removal (EOR) provides survival benefit for some lower grade gliomas (LGGs), but it is often difficult to achieve both high EOR preservation brain function. Our institute working on intraoperative rapid LGGs using HRM method IDH mutation immunostaining p53/ATRX 1p/19q codeletion an decesion making. We report...
Abstract BACKGROUNDS Based on the comprehensive gene association studies in recent years, revision was issued 2016 WHO classification, integrating genetic information glioma diagnosis. Many have been reported correlation between each molecular subtype and prognosis new classification. Gliomas surgery is required to maximum tumor resection with functional preservation. Currently, our institute decides a surgical strategy based morphological diagnosis from obtained tissue during operation. We...
Abstract Antiseizure drug (ASD)-induced skin rash remains the main side effect of seizure management in patients with glioma. New generations ASDs, such as levetiracetam (LEV) and lacosamide (LCM) are associated less frequent rashes than conventional ASDs. However, there few reports regarding incidence by LEV LCM Therefore, aim this study was to investigate risk factors LEV- LCM-associated We compared ASD-associated between 353 glioma 125 meningioma, who received or underwent surgery 2017...
Abstract BACKGROUND Surgical site infection(SSI) in neurosurgery can increase mortality and worsen functional outcome. There are few reports on risk factors for SSI glioma surgery. In this study, we investigated the surgery at our institution. METHODS We included 1013 patients with gliomas who underwent craniotomy between November 2013 March 2022 was defined as requiring surgical treatment. Various including age, gender, number of operations, prior radiology, chemotherapy, use intraoperative...