A5100352055- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- interferon and immune responses
- RNA Research and Splicing
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Wind and Air Flow Studies
- Urban Heat Island Mitigation
- Noise Effects and Management
- Wnt/β-catenin signaling in development and cancer
- Cardiovascular Disease and Adiposity
- Pharmacological Receptor Mechanisms and Effects
- S100 Proteins and Annexins
- Genomics and Phylogenetic Studies
- Neonatal Respiratory Health Research
- RNA regulation and disease
- Pregnancy and preeclampsia studies
- TGF-β signaling in diseases
- Natural product bioactivities and synthesis
- Receptor Mechanisms and Signaling
- Plant Water Relations and Carbon Dynamics
- Molecular Biology Techniques and Applications
- Chromosomal and Genetic Variations
Qingdao Agricultural University
2023-2024
Inner Mongolia Agricultural University
2023
Northwest A&F University
2021-2022
Zhengzhou University
2021-2022
China-Japan Friendship Hospital
2022
Weifang People's Hospital
2021
Guangzhou Medical University
2020
Linyi People's Hospital
2007-2020
Agriculture and Forestry University
2020
Huazhong University of Science and Technology
2016
The level of muscle development in livestock directly affects the production efficiency livestock, and contents intramuscular fat (IMF) is an important factor that meat quality. However, molecular mechanisms through which circular RNA (circRNA) IMF remains largely unknown. In this study, we isolated myoblasts preadipocytes from fetal bovine skeletal muscle. Oil Red O BODIPY staining were used to identify lipid droplets preadipocytes, anti-myosin heavy chain (MyHC) immunofluorescence was...
Thyroid cancer (TC) is an endocrine disease, and its progression regulated by many factors, including circular RNAs (circRNAs). However, as a new circRNA, the role of circ_0058124 in TC worth further exploration.The expression levels circ_0058124, microRNA-940 (miR-940) mitogen-activated protein kinase 1 (MAPK1) were assessed quantitative polymerase chain reaction (q-PCR). The characteristic was identified oligo (dT)18 primers, Ribonuclease R (RNase R) Actinomycin D (ActD), localization...
Circular RNA (circRNA) is a form of endogenous that can regulate gene expression and participate in the regulation myogenesis. However, molecular mechanisms potential roles circRNAs bovine muscle development remain largely unknown. Nevertheless, splicing factors regulating biogenesis circRNA have not yet been characterized. In this study, we identified novel circRNA, circMEF2D, formed by back-splicing constitutive exons (exons 5-7) MEF2D gene. Functional assays showed circMEF2D inhibited...
Circular RNAs (circRNAs) are powerful factors in regulating various cancer behaviors. It has been manifested previous researches that circular RNA hsa_circ_0005909 (circ_0005909) exhibits a regulatory function osteosarcoma. However, there no other studies on whether circ_0005909 displays potential functions the progression of non-small-cell lung (NSCLC).RT-PCR was applied to examine expression NSCLC. To study specific behaviors NSCLC cells after knockdown, cell counting kit-8 (CCK-8) assays,...
Abstract Due to a poor availability of reliable biomarkers, detecting gestational diabetes mellitus (GDM) in early pregnancy remains challenge. Novel biomarkers like Circular RNAs (circRNAs) may be promising diagnostic tool. The aim this study was (a) identify circRNAs deregulated GDM and (b) evaluate the potential GDM. expression profiling 6 paired women (with without GDM) measured by microarray. levels five most relevant were validated 12 participants qRT-PCR. To verify reproducibility...
Abstract Background Skeletal muscle development, a long-term and complex process, is controlled by set of the myogenic genes. Circular RNAs (circRNAs), class noncoding RNA, have been shown to regulate various biological processes. Recent studies indicate circRNAs may be involved in myogenesis, but role regulatory mechanism myogenesis largely unknown. In present study, circCPE was firstly found promote bovine myoblast proliferation inhibit cell apoptosis differentiation influencing expression...
Cysteine-rich 61 (Cyr61) is a member of the CCN protein family that has been implicated in diverse biological processes such as cell adhesion, proliferation, angiogenesis, and tumorigenesis. Altered expression Cyr61 found to be associated with human cancers. Here we show was up-regulated prostate cancer lines tumor tissues. A significant correlation between benign prostatic hyperplasia (P = 0.002). However, there no levels PSA 0.2). may represent an independent biomarker potentially useful...
Sepsis-induced acute lung injury (ALI) is a severe cause of death. Increasing evidence has identified circular RNAs (circRNAs) acting as critical regulators human diseases. However, their expression pattern and underlying mechanisms in ALI remain unclear. Herein, we screened the circRNAs patients constructed murine model using lipopolysaccharides (LPS) induction. Functional analyses targeted circRNA were performed vivo vitro. Then, downstream miRNA mRNA specific identified. Compared to...
Given the dual roles in immune function and metabolism, liver emerge as a compelling candidate to bridge host defense metabolic adjustments during pathogen infections teleosts. In order dissect of response Sebastes schlegelii, we conducted an investigation into activities SOD, CAT GPX4, performed systematic analysis circRNA, miRNA mRNA expression profiles, well constructed circRNA-miRNA-mRNA regulatory networks S. schlegelii following Aeromonas salmonicida infection were present study. The...
The evolutionary origins of specialized organs pose significant challenges for empirical studies, as most such evolved millions years ago. Northern snakehead (Channa argus), an air-breathing fish, possesses a suprabranchial organ, common feature the Anabantoidei, offering unique opportunity to investigate function and organs. In this study, high-quality chromosome-level reference genome C. argus was constructed using PacBio HiFi sequencing Hi-C technology. final assembly size is 712.14 Mb,...
Abstract Background: The level of muscle development directly affects the production efficiency livestock, and content intramuscular fat (IMF) is an important factor affecting meat quality. Nevertheless, molecular mechanism embryonic circular RNA in IMF remains largely unknown. Methods: In this study, we isolated myoblasts preadipocytes from fetal bovine skeletal muscle. Oil Red O BODIPY staining were used to identify lipid droplets preadipocytes, anti-MyHC immunofluorescence was myotubes...
Expressions of sFRP1 and β-Catenin in Cervical Cancer This study aimed to investigate the expressions secreted frizzled-related protein 1 (sFRP1) β-catenin cervical cancer intraepithelial neoplasia (CIN), explore relationship between both proteins prognosis cancer. Immunohistochemistry was performed detect (n=78), CIN (n=30) normal tissues (n=20), relationships with clinicopathological characteristics were analyzed. The positive rate 100%, 70% 33.3% tissues, cancer, respectively (P<0.05)....
Abstract Given the dual roles in immune function and metabolism, liver can be selected as an interesting candidate to bridge host defense metabolic adjustments during pathogen infections teleost. In order dissect of response Sebastes schlegelii , detection activities SOD, CAT GPX4, systematic analysis circRNA, miRNA mRNA expression profiles, well circRNA-miRNA-mRNA regulatory networks S. following Aeromonas salmonicida infection were performed present study. The results demonstrated content...
In recent years, the problem of crop yield reduction caused by drought has become increasingly serious in countries around world. China, particular, is facing a pressing issue water resource scarcity that limiting agricultural production and food security. To address this, studying resistance plants crucial to understanding limitations cultivated dealing with drought. It can also contribute an improvement plant theory provide theoretical foundation for sustainable development. this study, we...