A5024249642- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Hypothalamic control of reproductive hormones
- Circadian rhythm and melatonin
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Electrolyte and hormonal disorders
- Pituitary Gland Disorders and Treatments
- Tryptophan and brain disorders
- Cardiac Ischemia and Reperfusion
- Ferrocene Chemistry and Applications
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Hormonal and reproductive studies
- DNA and Nucleic Acid Chemistry
- Coordination Chemistry and Organometallics
- Biochemical Analysis and Sensing Techniques
- Sleep and related disorders
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Chemical Synthesis and Analysis
University of Szeged
2010-2021
Washington State University
1998-2006
Endocrine Society
2004
To determine the relationships among plasma ghrelin and leptin concentrations hypothalamic contents, sleep, cortical brain temperature (T crt ), feeding, we determined these parameters in rats three experimental conditions: free-feeding with normal diurnal rhythms, feeding restricted to 12-h light period (RF), subjected 5-h of sleep deprivation (SD) at beginning cycle. Plasma displayed rhythms peak preceding following major daily hour 1 after dark onset. RF reversed rhythm hormones...
Concentrations of insulin in the brain are severalfold higher than blood plasma levels. Insulin regulates metabolism, molecular composition, and cognitive performance microcircuits reduces food intake; cerebral levels altered diabetes, aging, obesity, Alzheimer's disease. Released by pancreatic β cells, passes blood-brain barrier, but sources locally released still remain unclear. We find that is strongly expressed GABAergic neurogliaform cells cortex rat detected single-cell digital PCR....
The role of the somatotropic axis in sleep regulation was studied by using lit/lit mouse with nonfunctional growth hormone (GH)-releasing (GHRH) receptors (GHRH-Rs) and control heterozygous C57BL/6J mice, which have a normal phenotype. During light period, mice displayed significantly less spontaneous rapid eye movement (REMS) non-REMS (NREMS) than controls. Intraperitoneal injection GHRH (50 μg/kg) failed to promote whereas it enhanced NREMS mice. Subcutaneous infusion GH replacement...
Several well-defined sleep regulatory substances, e.g., interleukin-1β, activate the heterodimeric transcription factor nuclear factor-κB (NF-κB). substances that inhibit sleep, interleukin-4, NF-κB activation. activation promotes production of several additional thought to be involved in regulation, nitric oxide. We investigated, therefore, whether there are diurnal rhythms brain and changes after deprivation. Mice were kept on a 12:12-h light-dark cycle. In one experiment, groups mice...
The somatotropic axis, and particularly growth hormone-releasing hormone (GHRH), is implicated in the regulation of sleep-wake activity. To evaluate sleep chronic deficiency, activity was studied dwarf (dw/dw) rats that are known to have a defective GHRH signaling mechanism pituitary normal Lewis rats, parental strain dw/dw rats. In addition, expression receptor (GHRH-R) mRNA hypothalamus/preoptic region also determined by means reverse transcription-PCR, content hypothalamus measured....
Previous reports indicate that hypothalamic growth hormone-releasing hormone (GHRH) promotes sleep and is involved in regulation. The aim of our experiments was to determine whether the GHRH somatostatin contents rat hypothalamus have diurnal variations they are altered by deprivation (SD). Hypothalamic samples were collected at 10 time points during 24-h light-dark cycle. SD started light onset. obtained after 4 8 h 1 2 recovery following SD. peptides determined means radioimmunoassay....
Burning mouth syndrome (BMS) is an intraoral burning sensation for which no medical or dental cause can be found. Recent studies suggest that primary neuropathic dysfunction might involved in the pathogenesis of BMS. Calcitonin gene‐related peptide (CGRP) plays important role development pain and serves as a biological marker trigeminovascular activation. The aim this study was to determine levels CGRP saliva BMS patients estimate activation were measured, by RIA method 78 16 healthy...
The effects of intracerebroventricular injections the long-lasting somatostatin analog octreotide (Oct) were studied on sleep and behavior in rats. Pyrogen-free physiological saline Oct (0.001, 0.01, 0.1 μg) or vehicle administered at light onset, electroencephalogram (EEG), motor activity, cortical brain temperature recorded during 12-h period. Plasma growth hormone (GH) concentrations measured samples taken 30-min intervals after Oct. (0.01 suppressed non-rapid eye movement (NREMS) for 1–2...
Receptors for gonadotropin releasing hormone (GnRH) are highly expressed in various human cancers including breast, ovarian, endometrial, prostate and colorectal cancer. Ligands like GnRH-I or the sea lamprey analogue GnRH-III represent a promising approach development of efficient drug delivery systems targeted tumor therapy. Here, we report on synthesis cytostatic effect 14 oxime bond-linked daunorubicin conjugates containing variety unnatural amino acids within peptide sequence. All...
Sleep alterations after a 1-min exposure to ether vapor were studied in rats determine if this stressor increases rapid eye-movement (REM) sleep as does an immobilization stressor. Ether before light onset or dark was followed by significant REM starting ∼3–4 h later and lasting for several hours. Non-REM (NREM) electroencephalographic slow-wave activity during NREM not altered. Exposure elicited prolactin (Prl) secretion. promoted hypophysectomized rats. If the hypophysectomy partial...
There is increasing evidence that different types of breast cancers are related to distinct risk factors. We analyzed the cancer with respect circulating insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-3, 17beta-estradiol, estrone, testosterone, androstenedione and sex hormone-binding globulin (SHBG), taking into consideration characteristics tumors. Plasma hormone levels 102 postmenopausal patients detected by mammography screening, matched controls were in relation...
Abstract Changes in growth hormone‐releasing hormone (GHRH), GHRH‐receptor (R), somatostatin and interleukin (IL)‐1β mRNA levels were determined fetal rat hypothalamic cultures after administration of IL‐1β (1, 10, 100 ng/ml, 2 h incubation), adult hypothalamus 5 intracerebroventricular injection (2.5 25 ng). stimulated GHRH‐R expression both vitro (10 ng/ml) vivo Somatostatin was significantly GHRH slightly reduced , while these species not altered response to IL‐1β. its own (25...
Viral infections induce excess non-rapid eye movement sleep (NREMS) in mice. Growth hormone-releasing hormone receptor (GHRH receptor) was previously identified as a candidate gene responsible for NREMS responses to influenza challenge The dwarf lit/lit mouse with nonfunctional GHRH used assess the role of viral-induced NREMS. After A virus infection duration and intensity [electroencephalogram (EEG) delta power] increased heterozygous mice normal phenotype, whereas EEG power decreased...
// Andrea Treszl 1,* , Zita Steiber 2,* Andrew V. Schally 3,4 Norman L Block Balazs Dezso 5 Gabor Olah 1 Bernadett Rozsa Klara Fodor Armin Buglyo Janos Gardi 6 Andras Berta 2 and Halmos 1,3 Department of Biopharmacy, University Debrecen, Medical Health Science Center, Hungary Ophthalmology, 3 Veterans Affairs Center Miami, FL, South Florida VA Foundation for Research Education, FL Pathology, Miller School Medicine, USA 4 Divisions Hematology/Oncology Endocrinology, Szeged, Faculty * These...