A5075774210- Multiple Sclerosis Research Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Ultrasound Imaging and Elastography
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Hypothalamic control of reproductive hormones
- Elasticity and Material Modeling
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Ultrasound and Hyperthermia Applications
- Functional Brain Connectivity Studies
- Cellular Mechanics and Interactions
- Radiomics and Machine Learning in Medical Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Diabetes Management and Research
- Advanced MRI Techniques and Applications
- Radiology practices and education
- Sleep and related disorders
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Tufts Medical Center
2022
Boston University
2022
University of Szeged
1995-2018
Fatigue is one of the most debilitating symptoms in patients with multiple sclerosis (MS). Despite its clinical significance, aetiology and pathophysiology MS-related fatigue are not well understood. Current evidence understanding neuroanatomical underpinnings reviewed this article. The aims paper to (1) review findings previous structural neuroimaging studies on summarize consistent regarding brain circuitry associated MS, (2) contextualize these neurochemistry relevant circuits (3) discuss...
Noninvasive measurement of fast neuronal activity, based on tissue stiffness maps from MRI elastography, is presented.
Background/Objectives: Ghrelin and growth hormone-releasing peptide 6 (GHRP-6) are peptides which can stimulate GH release, acting through the same receptor. its receptor have been involved in reward sensation addiction induced by natural artificial drugs, including nicotine. The present study aimed to investigate impacts of ghrelin GHRP-6 on horizontal vertical activity rats exposed chronic nicotine treatment followed acute withdrawal. Methods: Male female Wistar were daily intraperitoneal...
It is unclear whether fatigue a consequence or predictive trait of disease worsening.To investigate the value toward conversion to confirmed moderate-severe disability in patients with relapsing-remitting multiple sclerosis (RRMS).We retrospectively selected from Comprehensive Longitudinal Investigations MS at Brigham and Women's Hospital (CLIMB) study cohort RRMS who converted (⩾2 years) Expanded Disability Status Scale (EDSS) score ⩾3 within follow-up period years. We contrasted Modified...
Glioblastoma (GBM) is the most common primary brain tumor. It highly malignant and has a correspondingly poor prognosis. Diagnosis monitoring are mainly accomplished with MRI, but remain challenging in some cases. Therefore, complementary methods for tumor detection characterization would be beneficial. Using magnetic resonance elastography (MRE), we performed longitudinal study of biomechanical properties intracranially implanted GBM mice compared results to histopathology. The parameters...
Background: Fatigue in multiple sclerosis (MS) has been inconsistently associated with disruption of specific brain circuitries. Temporal fluctuations fatigue have not considered. Objective: The aim this study was to investigate the association diffusion abnormalities, using robust criteria for patient stratification based on longitudinal patterns fatigue. Methods: Patient stratification: (1) sustained (SF, n = 26): latest two Modified Impact Scale (MFIS) ⩾ 38; (2) reversible (RF, 25): MFIS...
Fatigue in multiple sclerosis (MS) has been associated with brain damage low replicability. Temporal fatigue fluctuations have not considered. We assessed whether sustained (SF) associates more strongly grey matter (GM) changes than reversible (RF). Patients were stratified into three groups according to historical levels: SF (n = 30, i.e. patients who reported at the latest ≥2 assessments), RF 31, fatigued assessment, but previously), and never (NF, n 37). Groups compared for GM volume...
Enlarged perivascular spaces (EPVSs) have been associated with relapses and brain atrophy in multiple sclerosis (MS). We investigated the association of EPVS clinical MRI features disease worsening a well-characterized cohort relapsing-remitting MS patients prospectively followed for up to 10 years.Baseline EPVSs were scored on 1.5T 30 converters moderate-severe disability, nonconverters matched baseline characteristics.EPVS scores not significantly different between nonconverters, nor...
Reports on the relationships between white matter lesion load (WMLL) and fatigue anxiety in multiple sclerosis (MS) are inconsistent.To investigate association of total tract-specific WMLL with anxiety.Total regional T2 was assessed for 19 tracts 48 MS patients (30 females). ICBM-DTI-81 Atlas-based parcellation combined segmentation T2-weighted magnetic resonance imaging (MRI). Fatigue, anxiety, depression were using Fatigue Impact Scale, State Trait Anxiety Inventory, Beck Depression...
Anti-angiogenic treatment of glioblastoma (GBM) complicates radiologic monitoring. We evaluated magnetic resonance elastography (MRE) as an imaging tool for monitoring the efficacy anti-VEGF GBM.Longitudinal studies were performed in orthotopic GBM xenograft mouse model. Animals treated with B20 antibody compared to untreated controls regarding survival (n = 13), classical MRI-contrasts and biomechanics quantified via MRE 15). Imaging was on a 7 T small animal horizontal bore MRI scanner....
Abstract Background Deep grey matter (DGM) atrophy in multiple sclerosis (MS) and its relation to cognitive clinical decline requires accurate measurements. MS pathology may deteriorate the performance of automated segmentation methods. Accuracy DGM methods is compared between controls, with lesions studied. Methods On images 21 subjects 11 three raters manually outlined caudate nucleus, putamen thalamus; outlines were combined by majority voting. FSL-FIRST, FreeSurfer, Geodesic Information...
Background: Magnetic resonance imaging (MRI) studies of multiple sclerosis–related fatigue had limited reproducibility. Temporal fluctuations have not been considered. Objective: To investigate whether a novel group allocation that reflects temporal dynamics improves our ability to detect fatigue-associated structural brain abnormalities. Methods: Patient stratification based on biennial assessments: sustained (SF, n = 29, fatigued at the latest ⩾2 assessments), one time-point (1F, 15,...