A5068548168- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Anesthesia and Pain Management
- Intensive Care Unit Cognitive Disorders
- Neuropeptides and Animal Physiology
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Obstructive Sleep Apnea Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Tracheal and airway disorders
- Hemodynamic Monitoring and Therapy
- Pain Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Electrolyte and hormonal disorders
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience of respiration and sleep
- Gastroesophageal reflux and treatments
- Epilepsy research and treatment
- Cardiac Valve Diseases and Treatments
Hirosaki University
2015-2024
Fukuoka University
2017
Kyushu University
2017
Fukuoka Dental College
2017
Hiroshima University
2017
Tokyo Medical and Dental University
2015
Hirosaki University Hospital
1996-2013
Indiana University School of Medicine
2003-2007
In-Q-Tel
2003
Ministry of Education, Culture, Sports, Science and Technology
2002
There is no effective treatment for intractable postherpetic neuralgia. Because there evidence that neuralgia has an inflammatory component, we assessed with intrathecally administered methylprednisolone to reduce pain in patients this disorder.
We investigated the associations between postoperative delirium (POD) and both relative ratio of alpha (α)-power electroencephalography (EEG) inflammatory markers in a prospective, single-center observational study.We enrolled 84 patients who underwent radical cancer surgeries with reconstruction for esophageal cancer, oral floor or pharyngeal under total intravenous anesthesia. collected perioperative EEG data markers, including neutrophil gelatinase-associated lipocalin, presepsin,...
Various growth factors are involved in sleep regulation. Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family; it and its receptors found normal brain. Furthermore, cerebral cortical levels of BDNF mRNA have a diurnal variation increase after deprivation. Therefore, we investigated whether would promote sleep. Twenty-four male Sprague-Dawley rats (320–380 g) 25 New Zealand White rabbits (4.5–5.5 kg) were surgically implanted with electroencephalographic (EEG)...
Nuclear factor-κB (NF-κB) is a transcription factor that when activated promotes production of several sleep-promoting substances such as interleukin-1β (IL-1β), tumor necrosis factor-α, and nerve growth factor. Therefore, we hypothesized inhibition NF-κB activation would attenuate sleep. A cell-permeable inhibitor peptide (IP) was injected intracerebroventricularly (5 50 μg for rats, 100 rabbits). On separate day, time-matched control injections inactive were done in the same animals. The...
The effects of inhalation anesthesia (2% isoflurane, sevoflurane, or enflurane) and intraperitoneal with pentobarbital (65 mg/kg) were compared in rats using an electrocardiogram (ECG) determination blood oxygen saturation (SPO2) levels. Following anesthesia, heart rate (HR) SPO2 acceptable while decreased HR significantly. This indicates that is more preferable than when evaluating cardiovascular factors. Additionally, significantly increased variability (HRV), suggesting a regulatory...
Postoperative delirium (POD) is a well-recognized postoperative complication and associated with increased morbidity mortality. We investigated whether the preoperative neutrophil-lymphocyte ratio (NLR) could be an effective predictor of POD after head neck free-flap reconstruction. This was single-center, retrospective, observational study. analyzed perioperative data patients who had undergone elective reconstruction surgery. assessed Intensive Care Delirium Screening Checklist (ICDSC)...
Several well-defined sleep regulatory substances, e.g., interleukin-1β, activate the heterodimeric transcription factor nuclear factor-κB (NF-κB). substances that inhibit sleep, interleukin-4, NF-κB activation. activation promotes production of several additional thought to be involved in regulation, nitric oxide. We investigated, therefore, whether there are diurnal rhythms brain and changes after deprivation. Mice were kept on a 12:12-h light-dark cycle. In one experiment, groups mice...
Orexins (OXs) regulate wakefulness, and a lack of OX Type-I receptors cause narcolepsy. selectively increases norepinephrine (NE) release from rat cerebral cortical slices, brain noradrenergic neurons are involved in the sleep-wakefulness cycle. Ketamine NE cortex. We hypothesized that would affect ketamine anesthesia's interactions with neuronal activity.We used Sprague Dawley rats. studied 1) vivo effects orexin A (OXA) SB-334867-A (Orexin-1 receptor antagonist) on ketamine-induced...
Proinflammatory cytokines, including interleukin-1 beta (IL-1 beta) and tumor necrosis factor- alpha (TNF- alpha) are involved in sleep regulation. IL-10 is an anti-inflammatory cytokine that inhibits proinflammatory production. We hypothesized could attenuate sleep. Thirty-one male rabbits were used. Three doses of (5 ng, 50 250 ng) injected intracerebroventricularly during the rest (light) period. One dose (250 was active (dark) cycle. Appropriate time-matched control injections saline...
Proinflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α, are involved in sleep regulation. IL-4 is an antiinflammatory cytokine that inhibits proinflammatory production. The hypothesis should attenuate was studied by determining the effects of on rabbit spontaneous sleep. Thirty-six rabbits were used. Four doses (0.25, 2.5, 25, 250 ng) injected intracerebroventricularly during rest (light) period. One dose (25 active (dark) cycle. Appropriate time-matched...
Neuropeptide S (NPS) and its receptor (NPSR) is a novel neuropeptide system that regulates arousal anxiety. A link between natural sleep general anesthesia has been suggested. Therefore, we hypothesized the NPS neuronal may also modulate anesthesia.The effects of intracerebroventricular [D-Cys(tBu)(5)]NPS, peptide NPSR antagonist, on ketamine thiopental time were measured in rats. Anesthesia was defined as interval loss righting reflex recovery.Intracerebroventricular 1 to 30 nmol...
Orexin A and B, recently identified in the rat hypothalamus are endogenous neuropeptide agonists for G‐protein coupled orexin‐1 (OX1) orexin‐2 (OX2) receptors. In present study, we have examined effects of orexin A, B raised extracellular K + on noradrenaline release from cerebrocortical slice. We compared this with other sleep – wake‐related (excitatory) neurotransmitters; dopamine, glutamate, serotonin histamine. Neurotransmitter studies were performed slices incubated modified Krebs...
Several growth factors are implicated in sleep regulation. Epidermal factor (EGF) is found the brain, and it influences production of several sleep-promoting substances. We determined, therefore, whether administration exogenous EGF affected spontaneous rabbits. Twenty-five rabbits were implanted with electroencephalographic electrodes, a brain thermistor, an intracerebroventricular guide cannula. Three doses (0.5, 5, 25 μg) used. The animals injected intracerebroventricularly saline as...
Background Tobacco smoking inhibits alveolar macrophage function, but cessation of markedly reduces the risk postoperative pulmonary complications. The authors therefore evaluated effect nonsmoking duration on both antimicrobial and inflammatory functions macrophages during anesthesia surgery. Methods studied 15 patients who had never smoked, current smokers, 41 former all whom underwent general anesthesia. Former smokers were further allocated to one three groups depending their smoke-free...