A5079150842- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Insect Pest Control Strategies
- Sesquiterpenes and Asteraceae Studies
- Bacterial biofilms and quorum sensing
- Plant chemical constituents analysis
- Piperaceae Chemical and Biological Studies
- Digestive system and related health
- Medicinal Plants and Neuroprotection
- Antimicrobial Resistance in Staphylococcus
- Probiotics and Fermented Foods
- Allergic Rhinitis and Sensitization
- Herbal Medicine Research Studies
- Free Radicals and Antioxidants
- Drug-Induced Hepatotoxicity and Protection
- Gut microbiota and health
- Nephrotoxicity and Medicinal Plants
- Psychedelics and Drug Studies
- Malaria Research and Control
- Forensic Toxicology and Drug Analysis
- Allelopathy and phytotoxic interactions
- Medicinal Plant Extracts Effects
- Antimicrobial Peptides and Activities
University of Montenegro
2016-2025
Sapienza University of Rome
2015-2019
Pseudomonas aeruginosa is a ubiquitous organism and opportunistic pathogen that can cause persistent infections due to its peculiar antibiotic resistance mechanisms ability adhere form biofilm. The interest in the development of new approaches for prevention treatment biofilm formation has recently increased. aim this study was seek non-biocidal agents able inhibit formation, order counteract virulence rather than bacterial growth avoid selection escape mutants. Herein, different essential...
Herein, an extended investigation of Tea tree oil (TTO) against a number multi-drug resistant (MDR) microorganisms in liquid and vapor phases is reported.The activity TTO was tested methicillin-sensitive Staphylococcus aureus (MSSA), Escherichia coli, clinical strains methicillin-resistant S. (MRSA), extended-spectrum beta lactamases producer carbapenem-sensitive Klebsiella pneumoniae (ESBL-CS-Kp), carbapenem-resistant K. (CR-Kp), Acinetobacter baumannii (CR-Ab), Pseudomonas aeruginosa...
Steam distillation is known to be the most prevalent method of essential oil extraction. Despite many studies on extraction methods, there no report about impact process duration yield and quality. A new 24-h steam for plant oils presented. For improving total yield, prolonged continued isolation was used. selection species from Lamiaceae Apiaceae families subjected direct were collected at different times (1, 2, 3, 6, 12 24 h). The analysis included either annual or perennial monitored in...
Biofilm resistance to antimicrobials is a complex phenomenon, driven not only by genetic mutation induced resistance, but also means of increased microbial cell density that supports horizontal gene transfer across cells. The prevention biofilm formation and the treatment existing biofilms currently difficult challenge; therefore, discovery new multi-targeted or combinatorial therapies growing. development anti-biofilm agents considered major interest represents key strategy as non-biocidal...
Essential oils (EOs) exhibit a broad spectrum of biological activities; however, their clinical application is hindered by challenges, such as variability in chemical composition and chemical/physical instability. A critical limitation the lack consistency across EO samples, which impedes standardization. Despite this, evidence suggests that EOs with differing profiles often display similar (micro)biological activities, raising possibility standardizing based on effects rather than...
Background/Objective: Phenolic compounds are considered to be the most important parameters of wine quality, contributing not only its organoleptic characteristics, but various health benefits associated with consumption. Although these successfully extracted from grapes and winemaking by-products, there is no data on extraction itself. This particularly interesting in light fact that variability polyphenols attributed stage grape ripening genetic or environmental factors; it affected by...
A comprehensive study on essential oils extracted from different Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) Ball samples Tarquinia (Italy) is reported. In this study, the 24-h steam distillation procedure for oil preparation, in terms of harvesting and extraction times, was applied. The Gas chromatography-mass spectrometry (GC/MS) analysis showed that C. belong to pulegone-rich chemotype. 44 revealed along with pulegone, some other chemicals may participate exerting related...
A comprehensive study on essential oil samples of Foeniculum vulgare Miller from Tarquinia (Italy) is reported. 24-h systematic steam distillation was performed different harvested applying extraction times. The GC-MS analysis the residue outcome showed o-cymene, α-phellandrene, α-pinene and estragole as major constituents. predominance continued presence o-cymene makes this fennel a rather unique chemotype. An evident correlation between antifungal activity phenological stage demonstrated....
An experimental investigation on essential oil of a Montenegrin Helichrysum italicum (Roth) G. Don fil. (Asteraceae) is reported. The was analysed in both liquid and vapour phases. Gas chromatography-mass spectrometry analysis the showed predominance sesquiterpenes with β-eudesmene (21.65%) β-bisabolene (19.90%) as major ones. Monoterpene fraction mainly represented by α-pinene (16.90%) neryl acetate (10.66%). Head-space technique revealed phase enriched monoterpenes (78.76%) predominance....
The opportunistic pathogen Pseudomonas aeruginosa is often involved in airway infections of cystic fibrosis (CF) patients. It persists the hostile CF lung environment, inducing chronic due to production several virulence factors. In this regard, ability form a biofilm plays pivotal role colonization by P. aeruginosa. Bacterial mitigation and bacterial cell adhesion hampering and/or reduced formation could represent major target for development new therapeutic treatments infection control....
A comprehensive study on essential oils (EOs) extracted from some Mentha suaveolens L. samples, collected in the countryside of Tarquinia, is reported. In this study, procedure for oil preparation, terms harvesting and extraction time, was analyzed detail first time. The GC/MS analysis, carried out 18 revealed that piperitenone oxide (PO), main oils’ chemical constituent, primarily responsible related antifungal activity. Nevertheless, EOs with lower PO content indicate other chemicals, such...
A comprehensive study on essential oil and different solvent extracts of Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood (Lamiaceae) from Montenegro is reported. The gas chromatography-mass spectrometry analysis the revealed a total 43 components with bicyclogermacrene (23.8%), germacrene D (8%), (E)-caryophyllene (7.9%) spathulenol (5.5%) as major ones. Sesquiterpenoid group was found to be most dominant one (64.8%), 19.9% oxygenated forms. In crude methanol extract...
In the last decade essential oils have attracted scientists with a constant increase rate of more than 7% as witnessed by almost 5000 articles. Among prominent studies are investigated antibacterial agents alone or in combination known drugs. Minor involved oil inspection potential anticancer and antiviral natural remedies. line authors previous reports investigation an in-house library extracted blocker HSV-1 infection is reported herein. A subset was experimentally tested vitro model...
The antioxidant activity of essential oils (EOs) is an important and frequently studied property, yet it not sufficiently understood in terms the contribution EOs mixtures’ constituents biological properties. In this study, a series 61 commercial were first evaluated as antioxidants vitro, following closely possible cellular pathways reactive oxygen species (ROS) generation. Hence, assessed for ability either to chelate metal ions, thus interfering with ROS generation within respiratory...
A comparative study on essential oils extracted from Mentha suaveolens Ehrh. Italy is reported. Two extraction procedures were investigated: hydrodistillation and steam distillation, carried out as a continuous fractionated procedure. Fresh dried plant material two harvests was used. The method yielded higher amount of oil. significantly richer in oil per kg starting material. Gas chromatography-mass spectrometry analysis 112 samples showed that the belong to piperitenone oxide-rich...
A study on essential oil fractions of the Western Balkan endemic Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood collected in Montenegro is reported. The 24-h systematic steam distillation extraction procedure was performed. gas chromatographic/mass spectrometric (GC/MS) analysis showed γ-elemene and spathulenol as two main constituents, revealing a new chemotype this plant species. Although varying content these compounds, which makes quite different between each other,...
Previous studies relating to prolonged and fractionated distillation procedures highlighted essential oils' (EOs) chemical composition be significantly dependent on the extraction duration harvesting time. As a continuation, hydrodistillation procedure was applied ripe fruit material of fennel, Foeniculum vulgare Miller (Apiaceae), collected from three localities in Montenegro (Podgorica, Nikšić, Kotor) furnish total 12 EOs. Liquid vapor phases samples were analyzed by Gas...
A comprehensive study on essential oil samples extracted from Ridolfia segetum Moris (Apiaceae) collected in Tarquinia (Italy) is reported. In this study, a 30-hour, fractionated, steam distillation procedure for preparation was applied. The gas chromatographic-mass spectrometry analysis showed monoterpene o-cymene and phenylpropanoid dill-apiol as the major oil's constituents revealing new chemotype dependent extraction duration. Great impact of duration process chemical profile observed;...
This report summarizes the chemical composition analysis of