Sarcoidosis is a disorder of unknown etiology affecting many systems and characterized by non-caseating granulomas. Subcutaneous sarcoidosis the rarest form specific lesions in cutaneous sarcoidosis. It occurs more frequently fourth decade life common females than males. Multiple asymptomatic to slightly painful, firm, mobile, round oval, skin-colored, or erythematous nodules occur bilateral asymmetric pattern on extremities. In differential diagnosis, other diseases presenting with...

The cyst of the canal Nuck (CCN) is an extremely rare pathology that occurs as a result inability to obliterate processus vaginalis. No standard therapeutic procedure currently exists, and condition remains unfamiliar gynecologists. In this report, we aimed discuss treatment CCN with minimally invasive method. A 33-year-old woman diagnosed was treated laparoscopic total extraperitoneal approach best postoperative recovery. Awareness CNN critical for appropriate diagnosis management. classic...

Laryngeal chondrosarcoma is rare and accounts for 0.2% of all larynx malignancies.Although the most common sarcoma seen in larynx, laryngeal involvement by cartilage tumors rare.In this article, we aimed to present differential diagnosis located thyroid cartilage, which a site, 75-year-old male patient.The patient underwent total laryngectomy otolaryngology department.The macroscopy material sent pathology laboratory revealed 3x2 cm tumor with polypoid extension lumen from bottom right vocal...

Granuloma annulare (GA) is a benign, granulomatous cutaneous disease without clear etiology. Disseminated and drug induced granuloma rare presentation. We present 47-year-old woman with diffuse circular erythematous eruptions following treatment levetiracetam. Her clinical histopathological findings were compatible the diagnosis of annulare. To best our knowledge, there no previous report this skin as result levetiracetam use. case to highlight antiepileptic possible etiologic agent in disseminated

Objective: To analyse partial and total gastrectomy specimen in items of immunohistochemical staining the stem cell CD44 CD133; to determine their relationship pathological stage, other clinicopathological prognostic parameters, predictive value.

Aim: Among the endocrine malignancies, thyroid carcinoma (TC) is most common. However, anaplastic TC accounts for 1-2% of these cancers. The aim this study was to evaluate demographic and pathologic features, treatments, survival patients with TC. Methods: Anaplastic who applied our medical oncology clinics between 01.01.2012 -01.12.2018 were retrospectively evaluated. Results: A total 8 included in study. There 4 female male a median age 68 (minimum 61-maximum 83) years. initial complaint...

Introduction: Pro-inflammatory/anti-inflammatory cytokine and oxidant/antioxidant imbalances develop in acute respiratory distress syndrome cases, a significant cause of morbidity mortality childhood.This study aims to investigate whether Achillea millefolium, with its antioxidant anti-inflammatory effects, can be used the treatment lung injury.Methods: A total 36 male Wistar rats were divided into four groups.Acute injury was induced by cecal ligation puncture (CLP).Serum samples analyzed...

Vascular anomalies rarely emerge in the gastrointestinal tract. The most prevalent benign vascular lesions include angiodysplasia, Dieulafoy’s lesion, ectasia, malformations, and hemangiomas. Florid proliferation (FVP) is also a rare lesion associated with intussusception adults. In infants, there are only few cases literature. Although FVP usually presents as mass intestine, it nonneoplastic thought to occur due reactive process. this study, we present case of an attack focal necrotizing...

Photoaging is characterised by cutaneous changes caused exposure to ultraviolet light over time. Quercetin a bioflavanoid with antioxidant, antineoplastic, and anti-inflammatory effects. This study investigated the therapeutic effects of topical quercetin on photoaging, phenomenon not previously studied in A (UVA)-induced photoaging.

The purpose of this study was to examine the protective and therapeutic effects okra (Abelmoschus esculentus [AE]) seed extract, with its known antioxidant, immunomodulatory, anti-inflammatory properties, in an acetaminophen (paracetamol, N-acetyl- para-aminophenol)-induced model hepatotoxicity subsequent acute non-traumatic brain damage.Forty male Wistar rats were randomly divided into five equal groups, control, paracetamol (P), extract (AE), + (P AE), N-acetyl cysteine (NAC) AE N)....

This study aimed to evaluate the effect of systemically administered methylphenidate hydrochloride (MPH) on new bone formation in premaxillary suture after rapid maxillary expansion (RME).Thirty-three Wistar rats were divided into four groups: Group 1 (high dose, 30/60 mg/kg MPH), 2 (low 4/10 3 (positive control) and 4 (negative control).RME was applied 70th day study. A 5-day RME period followed by a 12-day retention period. The experiment terminated 87th day. Micro-CT for radiological...

Aim: It is known that most of the antiepileptic drugs have negative effects on liver.Pinacidil a nonselective opener KATP channels, including plasma membrane and mitochondria.Glibenclamide an ATP -dependent K channel blocker ensuring intake calcium.Our aim in this experimental study was to examine pinacidil glibenclamide liver tissue rats with focal epilepsy.Method: Sixty male Sprague Dawley (2-4 months old, 200-250 gr) were used study.The divided into 4 groups, 15 each group.The groups...

Objective: The effect of wet cupping therapy on anxiety and thiol/disulfide homeostasis was evaluated in rats with premature ovarian failure (POF) induced by cyclophosphamide (CYC). Material Methods: Twenty four Wistar Albino female were divided into control (n=6), POF POF+wet (n=6) groups. CYC at a dose 200 mg/kg injected intraperitoneally to One week later, applied groups for 5 minutes. next day, Open Field Test Elevated Plus Maze all experimental evaluate anxiety. After sacrification,...

The aim of this study was to investigate the relationship PD-L1, PTEN, PHH3, and Ki-67 immunohistochemical stain expressions with prognostic clinicopathological parameters in breast cancer.Lumpectomy mastectomy materials from 85 patients operated at Department Pathology, Bolu Abant Izzet Baysal University, Faculty Medicine between 2014 2019 were retrospectively reviewed. examined. Immunohistochemical staining results compared found be associated prognosis.A statistically significant...

Amaç: Meme kanseri kadınlarda en sık görülen kanserdir.p16INK4a ve bcl-2 genleri hücre siklüs kontrolündeki major yolaklarla ilişkilidir.Aynı zamanda meme karsinogenezinde de rol oynarlar.Bu çalışmada invaziv duktal karsinom olgularında "Modifiye Scarff-Bloom-Richardson" mikroskopik derecelendirme sistemindeki histopatolojik parametreler ile p16 ekspresyonu arasındaki ilişki araştırılmıştır