A5014940113- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Biomarkers in Disease Mechanisms
- Neurological Disorders and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Neurological Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Venous Thromboembolism Diagnosis and Management
- DNA Repair Mechanisms
- Vestibular and auditory disorders
- Peripheral Artery Disease Management
- Hearing Loss and Rehabilitation
- Mitochondrial Function and Pathology
- Inflammation biomarkers and pathways
- Restraint-Related Deaths
- Stroke Rehabilitation and Recovery
- Heterotopic Ossification and Related Conditions
- Olfactory and Sensory Function Studies
- RNA modifications and cancer
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
Gdańsk Medical University
2015-2025
Inserm
2011-2016
Université Paris Cité
2011-2016
University Clinical Centre
2016
Délégation Paris 5
2016
Ospedale Sacro Cuore Don Calabria
2015
Salford Royal NHS Foundation Trust
2015
Danderyds sjukhus
2015
Cliniques Universitaires Saint-Luc
2015
The George Institute for Global Health
2015
Abstract RFC1 disease, caused by biallelic repeat expansion in RFC1, is clinically heterogeneous terms of age onset, disease progression and phenotype. We investigated the role size influencing clinical variables disease. also assessed presence meiotic somatic instability repeat. In this study, we identified 553 patients carrying expansions measured 392 cases. Pearson’s coefficient was calculated to assess correlation between at onset. A Cox model with robust cluster standard errors adopted...
Increased aortic stiffness (measured by carotid-femoral pulse wave velocity) and central augmentation index have been shown to independently predict cardiovascular events, including stroke. We studied whether velocity functional outcome after ischemic stroke.In a prospective study, we enrolled 99 patients with acute stroke (age 63.7 ± 12.4 years, admission National Institutes of Health Stroke Scale score 6.6 6.6, mean SD). Carotid-femoral (SphygmoCor) were measured 1 week onset. Functional...
: Altered blood pressure (BP) is a common phenomenon in acute ischemic stroke (AIS), with high BP being the most frequent scenario. The pathophysiology of changes AIS complex and only partially understood. available evidence indicates that extremely during associated poor outcome. Importantly, observed relationship between outcome may or not be causally related. Higher baseline BPs focal cerebral ischemia indicate preexisting hypertension, but also an effect both nonspecific stroke-related...
Arterial hypertension negatively influences the peripheral auditory system, causing sensorineural hearing loss. Much less is known about detrimental effects of on central functions.We tested 32 arterial patients and age sex-matched healthy volunteers with expanded tonal audiometry (0.125-12.5 kHz), distortion product otoacoustic emissions (0.75-8 horizontal minimum audible angle test for eight azimuths binaural stimulation random gap detection test.Peripheral hypertensive was impaired in...
Stroke is a leading cause of disability and one the major causes death worldwide. The short-term prognosis in individual patients highly variable cannot be explained solely by stroke severity. We investigated association left ventricular ejection fraction with early neurological outcome acute ischemic stroke.In total, 216 enrolled prospective study, underwent echocardiography applanation tonometry performed within 1 week after onset. At day 10, favorable was defined as 4 or more point...
Abstract RFC1 disease, caused by biallelic repeat expansion in , is clinically heterogeneous terms of age onset, disease progression and phenotype. We investigated the role size influencing clinical variables disease. also assessed presence meiotic somatic instability repeat. In this study, we identified 553 patients carrying expansions measured 392 cases. Pearson’s coefficient was calculated to assess correlation between at onset. A Cox model with robust cluster standard errors adopted...
Inherited ataxias are a group of highly heterogeneous, complex neurological disorders representing significant diagnostic challenge in clinical practice. We performed next‐generation sequencing (NGS) analysis 10 index cases with unexplained progressive cerebellar ataxia suspected autosomal recessive inheritance. A definite molecular diagnosis was obtained 5/10 families and included the following diseases: spastic Charlevoix‐Saguenay, POLR3B ‐related hypomyelinating leukodystrophy, primary...
Ischemic stroke causes mobilization of various groups progenitor cells from bone marrow to bloodstream and this correlates with the neurological status patients. The goal our study was identify activity chosen progenitor/stem in peripheral blood acute ischemic patients first 7 days after incident, through associations between levels clinical features Thirty-three 15 non-stroke control subjects had their venous collected repeatedly order assess CD45–CD34 + CD271+, CXCR4+, CXCR7+, CD133+...
Purpose: Outcome after ischaemic stroke (AIS) depends on multiple factors, including values of blood pressure (BP) and arterial stiffness (AS) in the early phase. It is also known that outcome affected by BP variability; however, influence AS oscillations phase its prognosis unknown. The aim our study was to assess relationship between changes markers outcome.Materials methods: Baseline clinical data, parameters, (pulse wave velocity [PWV], augmentation index [AIx]) were assessed 1, 6, >90...
Intracranial carotid artery calcification (ICAC), as a strong contributor to the occurrence of ischemic stroke, might be present in medial or intimal arterial layer. Traditional cardiovascular risk factors (CVRFs) are associated with ICAC; however, its association new markers vascular function is less understood. The paper aimed evaluate relationship between carotid-femoral pulse wave velocity (CF-PWV) and ICAC subtypes.
Objective: Stroke is the second most common cause of death. Although one important stroke causes hypertension, prognostic value blood pressure (BP) variability in victims remains inconsistent. The aim study was to assess relationship between and functional outcome after ischemic stroke. Design method: We analysed 94 patients with acute admitted Department Adult Neurology, Medical University Gdansk, Poland. Ambulatory monitoring (ABPM) performed week ABPM-based coefficients variation (CV,...
Objective: Aortic stiffness is a strong predictor of morbidity in various clinical conditions, including ischemic stroke. However, the prognostic significance peripheral arterial stiffness, defined as radial -carotid pulse wave velocity - for functional outcome stroke remains unknown. Design and method: We enrolled 189 patients (126 males, age 62.9±11.9 years, mean±SD) with acute (NIHSS score at admission 6.4±5.1 points). Radial-carotid (CR PWV), blood pressure (BP) heart rate (HR) were...
Objective: Ischemic stroke may be the first manifestation of cerebrovascular disease. However, subclinical organ complications underlying arterial stiffness and hypertension coexist stratify outcome. The study aimed to examine measures blood pressure (BP) on brain damage in acute ischemic patients. Design method: In a prospective study, we enrolled 132 (68,6% males) patients with stroke, AIS (age 62.2 ± 12.2 years, admission National Institutes Health Stroke Scale score 7.1 6.5, mean SD)....
Objective: Arterial stiffness is associated with the risk of stroke and its clinical sequelae as well. pressure-dependent, blood pressure still oscillates, especially in acute period stroke. The aim our study was to assess short- long-term variations arterial patients after ischemic Design method: We prospectively enrolled 51 adult (aged 61.9 ± 12.2 years; National Institutes Health Stroke Scale score, 5 [3–7]) admitted within first 24 hours from symptom onset. diagnosis were based on...
Purpose Wake-up stroke constitutes up to 1/4 of all ischaemic strokes; however, its pathomechanisms remain largely unknown. Although low nocturnal blood flow may be the underlying cause, little is known about pressure (BP) characteristic wake-up patients. The aim our study was look for differences in BP variables between and known-onset patients seek indices which could distinguish from other patients.Materials Methods In study, we included whom office measurement Ambulatory monitoring...
Objective: Acute hypertensive response after ischemic stroke is a self-limiting phenomenon and associated with functional outcome. Excessive BP fluctuations may reflect increased sympathetic nervous system activity, which can impair the brain repair stroke. Whether individual variation, based on difference between single office full ambulatory 24-hour measurements, have distinct long-term significance for outcome remains unknown. We tested hypothesis that subacute (BPD) [(office – mean...
Objective: Cerebral ischemic lesion volume determined by diffusion-weighted imaging (DWI) may be predictive of clinical severity and has been used as a surrogate outcome. We aimed to study the role blood pressure-derived measurements for prediction evolution in acute stroke patients. Design method: conducted prospective 28 patients (aged 58.2 ± 13.5, 23 men) with sudden onset during last 24 hours. DWI was performed immediately at admission (< hours from symptoms onset) on day 5. Blood...