A5078425193- Astrophysics and Cosmic Phenomena
- Dark Matter and Cosmic Phenomena
- Gamma-ray bursts and supernovae
- Neutrino Physics Research
- DNA and Nucleic Acid Chemistry
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Radio Astronomy Observations and Technology
- Ferroptosis and cancer prognosis
- Catalytic C–H Functionalization Methods
- Particle physics theoretical and experimental studies
- Metal complexes synthesis and properties
- Cholesterol and Lipid Metabolism
- Radiation Therapy and Dosimetry
- Free Radicals and Antioxidants
- Black Holes and Theoretical Physics
- Synthesis and Catalytic Reactions
- Echinoderm biology and ecology
- Cardiac Arrhythmias and Treatments
- Cyclopropane Reaction Mechanisms
- Cancer therapeutics and mechanisms
- Metalloenzymes and iron-sulfur proteins
- Particle Detector Development and Performance
- Noncommutative and Quantum Gravity Theories
- Cancer, Lipids, and Metabolism
Institute of High Energy Physics
2013-2025
Chinese Academy of Sciences
2014-2025
Shandong Normal University
2016-2024
Gansu Great Wall Electrical and Electronics Engineering Research Institute
2024
Zhejiang University
2007-2022
Sir Run Run Shaw Hospital
2022
Shandong University
2010-2014
The measurement of cosmic ray energy spectra, in particular for individual species, is an essential approach finding their origin. Locating the "knees" spectra important part and has yet to be achieved. Here we report a mixed Hydrogen Helium spectrum using combination ARGO-YBJ experiment prototype Cherenkov telescope LHAASO experiment. A knee feature at 640+/-87 TeV, with clear steepening spectrum, observed. This gives fundamental inputs galactic acceleration models.
The extended TeV gamma-ray source ARGO J2031+4157 (or MGRO J2031+41) is positionally consistent with the Cygnus Cocoon discovered by Fermi-LAT at GeV energies in superbubble. Reanalyzing ARGO-YBJ data collected from 2007 November to 2013 January, angular extension and energy spectrum of are evaluated. After subtracting contribution overlapping sources, excess map fitted a two-dimensional Gaussian function square region 10° × 10°, finding σext= 18 ± 05. observed differential dN/dE = (2.5 0.4)...
Ferroptosis is a recently discovered iron-dependent form of non-apoptotic cell death caused by the accumulation membrane lipid peroxidation products, which involved in various pathological conditions brain, kidneys, liver and heart.
The origin of site selectivity quinoline N-oxide substrate in Ir(III)-catalyzed amidation with tosyl azide was investigated computationally. reaction proceeds exclusively at the C8 position, instead C2 which has been reported previously many other reactions. C2-Amidation is kinetically impossible under condition according to our calculations, high apparent activation energy up 51.1 kcal/mol. energetic span caused by deep-lying 5-membered amido insertion intermediate, a strong stabilization...
Gastric carcinoma is a common type of malignant tumors and associated with high death rates. The pathogenesis gastric still unclear, increasing evidence shows that many factors contribute to this process. Chromokinesin KIF4 involved in multiple critical cellular processes. Recently, it has become apparent plays crucial suppressive role tumorigenesis. However, the human cancer unclear. In study, we examined expression profiles specimens generated cells stably express GFP-KIF4 fusion protein...
The ARGO-YBJ experiment is a full-coverage air shower detector located at the Yangbajing Cosmic Ray Observatory (Tibet, People's Republic of China, 4300 m a.s.l.). high altitude, combined with technique, allows detection extensive showers in wide energy range and offer possibility measuring cosmic ray proton plus helium spectrum down to TeV region, where direct balloon/space-borne measurements are available. has been stable data taking its full configuration from November 2007 February 2013....
The concept of ferroptosis inhibition has gained growing recognition as a promising therapeutic strategy for addressing wide range diseases. Here, we present the discovery four series ortho-aminophenol derivatives potential inhibitors beginning with endogenous substance 3-hydroxyanthranilic acid (3-HA) by employing quantum chemistry techniques, in vitro and vivo assays. Our findings reveal that these exhibit unique intra-H bond interactions, compelling ortho-amines to achieve enhanced...
Ferroptosis is a non-apoptotic, iron dependent form of regulated cell death that characterized by the accumulation lipid hydroperoxides.
Recently, a new synthetic methodology of rhodium-catalyzed carboamination/cyclopropanation from the same starting materials at different reaction conditions has been reported. It provides an efficient strategy for stereospecific formation both carbon- and nitrogen-based functionalities across alkene. Herein we carried out detailed theoretical mechanistic exploration reactions to elucidate switch between carboamination cyclopropanation as well origin chemoselectivity. Instead experimentally...
The addition of the unnatural P:Z base pair to four naturally occurring DNA bases expands genetic alphabet and yields an artificially expanded information system (AEGIS). Herein, structural feature oligonucleotides containing a novel is characterized using both molecular dynamics quantum chemistry. results show that incorporation artificial (P:Z) preserves global conformational duplex except for some local structures. Z-nitro group imparts new properties groove width, which widens major...
Besides inhibiting RecA activity at the protein level, Deinococcus radiodurans RecX can suppress induction transcriptional level. The regulation of on recA is independent activity, and its N terminus involved in this process.
Computational studies have been applied to gain insight into the mechanism of Pd(ii) catalyzed α-C-H functionalization N-methoxy cinnamamide. The results show that whole catalytic cycle proceeds via sequential six steps, including (i) catalyst Pd(t-BuNC)2 oxidation with O2, (ii) O-H deprotonation, (iii) t-BuNC migratory insertion Pd-C bond, (iv) acyl migration, (v) C-H activation and (vi) reductive elimination. regioselectivity for different sites depends on coordination structures α-C or...
Aminic radical-trapping antioxidants (RTAs), as one of the most important antioxidants, have not received sufficient attention yet. But, an increasing number aminic RTAs been identified ferroptosis inhibitors in recent years, which can potentially mediate many pathological states including inflammation, cancer, neurodegenerative disease, well ocular and kidney degeneration. This highlights importance field medicine. Herein, we systematically explored radical scavenging mechanism with a...
The multidrug resistance protein MRP1 is an ATP binding cassette (ABC) transporter that confers to many anticancer drugs and regulates redox homeostasis, inflammation, hormone secretion. actively transports compounds across cell membranes, the presence of glutathione (GSH) required in cases. However, process MRP1-mediated substrate transportation has been poorly understood. With extensive molecular dynamics simulations, we have found a sandwich-like structure which generated by GSH,...
Estrogen-related receptor α (ERRα), which is overexpressed in a variety of cancers has been considered as an effective target for anticancer therapy. ERRα inverse agonists have proven to effectively inhibit the migration and invasion cancer cells. As few crystalline complexes reported, molecular dynamics (MD) simulations were carried out this study deepen understanding interaction mechanism between ERRα. The binding free energy was analyzed by MM-GBSA method. results show that total...
The detailed formation mechanisms of C/N-nucleoside and the chemical model nucleobase which will be beneficial for C–C glycosidic bond.