A5012102764- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
Tsinghua University
2022-2024
As SARS-CoV-2 Omicron and other variants of concern (VOCs) continue spreading worldwide, development antibodies vaccines to confer broad protective activity is a global priority. Here, we report on the identification special group nanobodies from immunized alpaca with potency against diverse VOCs including subvariants BA.1, BA.2 BA.4/5, SARS-CoV-1, major sarbecoviruses. Crystal structure analysis one representative nanobody, 3-2A2-4, discovers highly conserved epitope located between cryptic...
DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared. In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vector AdC68 to express DS2. All elicited robust serum binding neutralizing antibodies following intramuscular priming boosting. induced strongest antibody responses, followed by SC-TM DS-Cav1. also provided...
Abstract As SARS-CoV-2 Omicron and other variants of concern continue spreading around the world, development antibodies vaccines to confer broad protective activity is a global priority. Here, we report on identification special group nanobodies from immunized alpaca with exceptional breadth potency against diverse sarbecoviruses including SARS-CoV-1, BA.1, BA.2. Crystal structure analysis one representative nanobody, 3-2A2-4, revealed highly conserved epitope between cryptic outer face...