A5100349833- Synthesis and Characterization of Heterocyclic Compounds
- DNA and Nucleic Acid Chemistry
- Antibiotic Resistance in Bacteria
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Carbohydrate Chemistry and Synthesis
- Bacterial biofilms and quorum sensing
- Catalytic C–H Functionalization Methods
- bioluminescence and chemiluminescence research
- Antimicrobial Resistance in Staphylococcus
- Glycosylation and Glycoproteins Research
- Synthesis and Catalytic Reactions
- Enzyme Production and Characterization
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Radical Photochemical Reactions
- Cancer therapeutics and mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Microtubule and mitosis dynamics
- Supramolecular Chemistry and Complexes
- Pluripotent Stem Cells Research
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Congenital heart defects research
University of Florida
2019-2025
Franklin College
2025
University of Georgia
2025
University of Central Florida
2025
Huazhong University of Science and Technology
2017-2024
Union Hospital
2024
Shaanxi Normal University
2023
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
University of California, San Francisco
2021
The data and regulatory considerations leading to the U.S. Food Drug Administration (FDA) January 30, 2012 approval of Erivedge (vismodegib) capsules for treatment patients with recurrent, locally advanced, or metastatic basal cell carcinoma (BCC) are described. FDA's decision was based primarily on results observed in a single-arm, parallel cohort, international trial vismodegib, administered orally at 150 mg daily until disease progression, pathologically confirmed, advanced (laBCC)...
The aryl hydrocarbon receptor (AHR), also known as the dioxin receptor, was originally characterized a xenobiotic that senses xenotoxicants. We investigated endobiotic and hepatic role of AHR in fatty liver energy metabolism identified endocrine factor mediates metabolic function AHR. Wild-type liver-specific constitutively activated human transgenic mice were used to investigate homeostasis. Adenovirus expressing short hairpin RNA targeting fibroblast growth 21 (FGF21) determine involvement...
Abstract A concise, diversity‐oriented approach for the synthesis of naturally occurring 3‐amino‐ and 3‐nitro‐2,3,6‐trideoxypyranose derivatives analogues thereof from simple sugars has been developed. In addition, we investigated various 3‐aminoglycosyl donors their application in glycosylation reactions. These studies led to successful a tetrasaccharide containing four different 3‐aminosugar components using ortho ‐alkynylbenzoate donors.
c-kit, the transmembrane tyrosine kinase receptor for stem cell factor, is required melanocyte and mast development, hematopoiesis, differentiation of spermatogonial cells. We show here that in heart, c-kit expressed not only by cardiac cells but also cardiomyocytes, commencing immediately after birth terminating a few days later, coincident with onset cardiomyocyte terminal differentiation. To examine function differentiation, we used compound heterozygous mice carrying W (null) W(v)...
Highly effective CuCl-mediated C—H alkoxylation of arenes and heteroarenes has been developed by using a 2-aminopyridine 1-oxide moiety as an N,O-bidentate directing group. The reaction proceeds smoothly broad range substrates to afford o-alkoxylated benzoic heteroaromatic amide products. Moreover, the system shows remarkable compatibility when hexafluoroisopropanol is used coupling parter; halogen, nitro, ether, alkoxy, ester, sulfonyl functional groups are all tolerated. group can be...
Bacterial biofilms are surface-attached communities consisting of non-replicating persister cells encased within an extracellular matrix biomolecules. Unlike bacteria that have acquired resistance to antibiotics, enable demonstrate innate tolerance toward all classes conventional antibiotic therapies. It is estimated 50-80% bacterial infections biofilm associated, which considered the underlying cause chronic and recurring infections. Herein, we report a modular three-step synthetic route...
Pathogenic bacteria demonstrate incredible abilities to evade conventional antibiotics through the development of resistance and formation dormant, surface-attached biofilms. Therefore, agents that target eradicate planktonic biofilm are significant interest. We explored a new series halogenated phenazines (HP) use N-aryl-2-nitrosoaniline synthetic intermediates enabled functionalization 3-position this scaffold. Several HPs demonstrated potent antibacterial biofilm-killing activities (e.g.,...
During infection, bacteria use an arsenal of resistance mechanisms to negate antibiotic therapies. In addition, pathogenic form surface-attached biofilms bearing enriched populations metabolically dormant persister cells. Bacteria develop in response insults; however, nonreplicating are innately tolerant all classes antibiotics. As such, molecules that can eradicate antibiotic-resistant and antibiotic-tolerant importance. Here, we report modular synthetic routes fluorine-containing...
Open AccessCCS ChemistryRESEARCH ARTICLES4 Dec 2023Bi-ortho-Carborane Unit-Riveted Perylene Monoimides: Structure-Tuned Optical Switches for Electron Transfer and Robust Thin Film-Based Fluorescence Sensors Nannan Ding†, Yu-Chan Liao†, Gang Wang, Kai-Hsin Chang, Zhaolong Ke Liu, Jiani Ma, Pi-Tai Chou Yu Fang Ding† Key Laboratory of Applied Surface Colloid Chemistry Ministry Education, School Chemical Engineering, Shaanxi Normal University, Shaanxi, Xi'an 710019 , Liao† Department Chemistry,...
Pancreatic cancer is a highly aggressive malignancy of the digestive system, with occult onset, rapid progression, and poor prognosis. The genetic heterogeneity pancreatic contributes to its malignant biological behavior. HMGA2 overexpressed in tumors known regulate tumor progression various cancers through HMGA2-IGF2BP2 axis, but role mechanism remain unclear. In this study, we demonstrated that promotes progression. We further revealed upregulates IGF2BP2, which stabilizes APLP2 mRNA via...
We report the synthesis and initial biological assessment of a halogenated phenazine–erythromycin conjugate prodrug <bold>5</bold> aimed to treat bacterial infections.
A modular and efficient method for the synthesis of α-substituted 1,2-dihydroquinolines is described. Under mild metal-free conditions, readily available N-carbamoyl undergo oxidative C-H alkynylation, alkenylation, allylation with a range potassium trifluoroborates using TEMPO oxoammonium salt as an oxidant.
In this study, we have designed, synthesized, and evaluated new halogenated phenazine prodrugs that could lead to breakthroughs in the treatment of antibiotic-resistant bacterial infections.
Bacterial biofilms are surface-attached communities of slow- or non-replicating cells embedded within a protective matrix biomolecules. Unlike free-floating planktonic bacteria, innately tolerant to conventional antibiotics and prevalent in recurring chronic infections. Nitroxoline, broad-spectrum biofilm-eradicating agent, was used probe biofilm viability. Transcript profiling (RNA-seq) showed that 452 2594 genes (17.4%) methicillin-resistant Staphylococcus aureus (MRSA) were differentially...
Background and Aims Induced pluripotent stem cells (iPSCs) provide an important tool for the generation of patient‐derived cells, including hepatocyte‐like by developmental cues through endoderm intermediate. However, most iPSC lines fail to differentiate into endoderm, with induction resulting in apoptosis. Approach Results To address this issue, we built upon published methods develop improved protocol. We discovered that doxycycline dramatically enhances efficiency iPSCs differentiation...
We have designed, synthesized and evaluated a new ether-linked halogenated phenazine-quinone prodrug model that demonstrates antibacterial activities against pathogenic bacteria.
Abstract A concise, diversity‐oriented approach for the synthesis of naturally occurring 3‐amino‐ and 3‐nitro‐2,3,6‐trideoxypyranose derivatives analogues thereof from simple sugars has been developed. In addition, we investigated various 3‐aminoglycosyl donors their application in glycosylation reactions. These studies led to successful a tetrasaccharide containing four different 3‐aminosugar components using ortho ‐alkynylbenzoate donors.
Pathogenic bacteria have devastating impacts on human health as a result of acquired antibiotic resistance and innate tolerance. Every class our current arsenal was initially discovered growth-inhibiting agents that target actively replicating (individual, free-floating) planktonic bacteria. Bacteria are notorious for utilizing diversity mechanisms to overcome the action conventional therapies forming surface-attached biofilm communities enriched in (non-replicating) persister cells. To...