A5045692507- Ophthalmology and Visual Impairment Studies
- Geriatric Care and Nursing Homes
- Peptidase Inhibition and Analysis
- Click Chemistry and Applications
- Signaling Pathways in Disease
- Corneal surgery and disorders
- Protease and Inhibitor Mechanisms
- Intergenerational Family Dynamics and Caregiving
- Chemical Synthesis and Analysis
- Biochemical and Molecular Research
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Folate and B Vitamins Research
- Ophthalmology and Visual Health Research
- Retinal Diseases and Treatments
- Enzyme function and inhibition
- Enzyme Production and Characterization
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- Sulfur Compounds in Biology
- Healthcare innovation and challenges
- Chemical Reaction Mechanisms
- Listeria monocytogenes in Food Safety
- ATP Synthase and ATPases Research
UNSW Sydney
2021-2025
Flinders University
2017-2024
Avenir Health
2021
Birla Institute of Technology and Science, Pilani
2004-2013
Elite School of Optometry
2013
SRM University
2013
Karnataka Health Promotion Trust
2008
University of Manitoba
2008
Purpose To report parents' awareness and perception of eye diseases in their children. Methods Thirty-five parents 16 care practitioners either participated in-depth interviews or focus group discussions. Data on were collected using interview guides with unstructured questions. transcribed, familiarized, coded, themes generated. Redundancy was considered as the end point data collection. Results The study results conveyed that aware common problems like refractive error, squint, cataract,...
Hearing and vision impairments are prevalent among residents in long-term care settings. frequently go unsupported, affecting residents' quality of life healthcare costs. This paper describes the protocol for a pre-post evaluation process pragmatic sensory support intervention (SSI) that was developed with residents, informal caregivers workers. A prospective pre-post-intervention trial within will be conducted, including three groups: (n = 87), 87) workers 40). Outcome measures include...
Vision impairment is common among older adults and affects dementia screening assessments, which include visually presented items. We developed validated a version of the Montreal Cognitive Assessment (MoCA) for people with vision that includes all cognitive domains included in standard MoCA. Visual components MoCA were adapted by developing alternative spoken forms. used both individual item analysis substitution to identify optimal set items inclusion People With Impairment (MoCA-VI) place...
Purpose To understand the vision-related quality of life (QoL) schoolchildren with uncorrected refractive error (URE). Methods A snapshot qualitative research design and homogeneous sampling strategy was adopted. Thirty-one, 27, 22 eye care practitioners, children, teachers participated in four, three, two focus group discussions, respectively. The participants were recruited from various parts Chennai, India. discussions audio recorded, transcribed, coded, analyzed. Results Eight themes...
To describe the concepts, strategies and field results of a project to scale up prevention programmes services for female sex workers (FSWs) in Karnataka, India.A strategy was developed urban worker interventions 18 districts southern Indian state Karnataka. Macro-level coverage objectives were defined by mapping locations where FSWs operate estimating their population size. Prevention initiated that contained at least 90% estimated FSW each district. Within location, micro-planning process...
Purpose Most of the causes childhood blindness are either treatable or preventable. Eye care–seeking behavior (ESB) parents for their children plays a pivotal role in reducing this problem. This study was done because there sparsity literature context and with view to help eye care professionals plan better programs identify factors facilitating and/or hindering ESB school-going an urban area. Methods adopted qualitative snapshot narrative design. In-depth interviews focus group discussions...
Abstract Purpose Patients’ perceptions about the functional impact of amblyopia and strabismus in daily life have not been explored extensively. Therefore, this study aimed to explore lived experiences adults with these conditions understand limitations they face their day‐to‐day life. Methods A qualitative design was adopted. Participants over 18 years age, a primary diagnosis (with or without strabismus) were recruited from community various eye care practices South Australia Victoria,...
The Fundamentals of Care Framework is an evidence-based, theory-informed framework that conceptualises high-quality fundamental care. places the nurse-patient relationship at centre care provision and outlines nurse behaviours required for development. Numerous instruments exist to measure behavioural aspects relationship; however, literature offers little guidance on which are psychometrically sound best core elements Framework. This study evaluated quality by (1) assessing their content...
While much is known about the psychosocial impacts of strabismus, little effects non-strabismic amblyopia on quality life (QoL). The aim this study was to explore long-term anisometropic amblyopia.A phenomenological qualitative investigation carried out a sample adults with amblyopia. Subjects participated in in-depth telephone interviews and described how their eye condition affected different aspects life. were audio-recorded, transcribed verbatim analysed iteratively form emergent...
A quantitative structure-activity relationship study has been conducted on two different series of acyclic hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The results suggest that in a few cases, the hydrophobic property molecules is major governing factor. However, some polarizability shown to be dominant. enzymes, MMP-9 and MMP-13, are behave similar fashion with any group
A quantitative structure-activity relationship (QSAR) study has been made on some bicyclic heteroaryl hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The inhibition potencies of compounds against a number MMPs were subjected to QSAR analysis and it was found surprisingly that the most crucial property molecules controlling drug action, hydrophobicity, be playing negative role here in cases vis-a-vis polarizability is shown conducive potency. Based this, proposed...
A quantitative structure–activity relationship (QSAR) study is made on a series of aromatic/heterocyclic sulfonamides and their charged derivatives acting as carbonic anhydrase (CA) inhibitors. These compounds were studied by Scozzafava et al. (J. Med. Chem. 2000; 43: 292) for the selective inhibition CAs—sulfonamides generally do not discriminate between different CA isozymes hence exhibit many undesirable side effects when used drugs against particular disease. In this communication, an...
A quantitative structure-activity relationship (QSAR) study has been made on a series of piperidine sulfonamide aryl hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The inhibitory potencies the compounds against two MMPs, MMP-2 and MMP-13, are found to be significantly correlated with hydrophobic properties molecules, suggesting that in both enzymes interaction is playing dominant role.
Clinical relevance Understanding the quality-of-life (QoL) impacts of amblyopia and strabismus from perspectives patients using validated tools would enable eye care practitioners to provide better clinical management.
A quantitative structure-activity relationship study has been made on some pyranyl hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The inhibition potencies of two different series compounds against MMP enzymes (MMP-1 and MMP-13) have analyzed found to be well correlated with hydrophobic indicator parameters the substituents. In both cases, parameter substituents a dominant factor. results this led discuss selectivity for MMP-13 over MMP-1.
There has been growing interest in exploring factors that influence the success or otherwise of welfare policies democratic countries, such as interrelationships between proposed policy and context it will be introduced into, sociodemographic characteristics population population’s previous experience with policies. However, there little exploration could general support for long-term care older people. The aim this study was to investigate attitudes determinants high-quality aged different...
A quantitative structure–activity relationship (QSAR) study has been made on a new series of digitalis-like Na+,K+-ATPase inhibitors in which the guanylhydrazone group replaced by an aminoalkyloxime group. The correlations obtained have shown that oxime moiety, primary amine group, overall size, and polarizability type substituents are higly beneficial to inhibition potency compounds their effect can be quantitatively assessed. also showed inotropic activity is very well correlated with potency.
A quantitative structure-activity relationship (QSAR) study is made on a series of Na+ channel blockers (diphenylacetamide derivatives) and K+ (blockers cardiac delayed rectifier potassium current IKs) (benzodiazepine derivatives). In both the cases, blocking activity found to be significantly correlated with Kiers first-order valence molecular connectivity index. Keywords: blockers, qsar, index