A5000559785- Congenital heart defects research
- Zebrafish Biomedical Research Applications
- Retinal Development and Disorders
- Developmental Biology and Gene Regulation
- Vascular Malformations Diagnosis and Treatment
- Physiological and biochemical adaptations
- Axon Guidance and Neuronal Signaling
- Cellular Mechanics and Interactions
- Intracerebral and Subarachnoid Hemorrhage Research
- Hippo pathway signaling and YAP/TAZ
- Cardiomyopathy and Myosin Studies
- Epigenetics and DNA Methylation
- interferon and immune responses
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Caveolin-1 and cellular processes
- Intracranial Aneurysms: Treatment and Complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Hemispheric Asymmetry in Neuroscience
- Retinal Diseases and Treatments
- Renal and related cancers
- Coronary Artery Anomalies
University of Potsdam
2017-2024
Heidelberg University
2012-2017
University Hospital Heidelberg
2014-2017
University Medical Centre Mannheim
2014-2017
University of Pisa
2010
Endothelial cells respond to different levels of fluid shear stress through adaptations their mechanosensitivity. Currently, we lack a good understanding how this contributes sculpting the cardiovascular system. Cerebral cavernous malformation (CCM) is an inherited vascular disease that occurs when second somatic mutation causes loss CCM1/KRIT1, CCM2, or CCM3 proteins. Here, demonstrate zebrafish Krit1 regulates formation cardiac valves. Expression heg1, which encodes binding partner Krit1,...
In the zebrafish embryo, onset of blood flow generates fluid shear stress on endocardial cells, which are specialized endothelial cells that line interior heart. High levels activate both Notch and Klf2 signaling, play crucial roles in atrioventricular valvulogenesis. However, it remains unclear why only individual ingress into cardiac jelly initiate Here, we show lateral inhibition between mediated by Notch, singles out Delta-like-4-positive cells. These jelly, where they form an abluminal...
Within the developing vertebrate retina, particular subtypes of amacrine cells (ACs) tend to arise from progenitors expressing basic helix-loop-helix (bHLH) transcription factor, Atoh7, which is necessary for early generation retinal ganglion (RGCs). All ACs require postmitotic expression bHLH pancreas factor Ptf1a; however, Ptf1a alone not sufficient give subtype identities. Here we use functional and in vivo time-lapse studies zebrafish retina investigate on developmental programs leading...
Divisions that generate one neuronal lineage-committed and self-renewing cell maintain the balance of proliferation differentiation for generation diversity. The asymmetric inheritance apical domains components division machinery has been implicated in this process, might involve interactions with fate determinants regulatory feedback loops an as yet unknown nature. Here, we report dynamics Anillin - essential F-actin regulator furrow component its contribution to progenitor divisions...
Rationale: Pathological biomechanical signaling induces vascular anomalies including cerebral cavernous malformations (CCM), which are caused by a clonal loss of CCM1/KRIT1 (Krev interaction trapped protein 1), CCM2/MGC4607, or CCM3/PDCD10. Why patients typically experience lesions only in lowly perfused venous capillaries the cerebrovasculature is completely unknown. Objective: In contrast, animal models with complete CCM proteins lack functional heart and blood flow exhibit within major...
During zebrafish heart formation, cardiac progenitor cells converge at the embryonic midline where they form cone. Subsequently, this structure transforms into a tube. Little is known about molecular mechanisms that control these morphogenetic processes. Here, we use light-sheet microscopy and combine genetic, biological pharmacological tools to show paralogous genes wnt9a/b are required for assembly of nascent In double mutants, cardiomyocyte delayed in their convergence towards midline,...
In the zebrafish embryo, onset of blood flow generates fluid shear stress on endocardial cells, which are specialized endothelial cells that line interior heart. This mechanical stimulation activates signaling pathways play crucial roles in atrioventricular valvulogenesis. High levels activate both Notch and Klf2 causing some to ingress into cardiac jelly initiate But it remains unclear why only specific, individual respond this way, how mechanosensitive contribute process. Here, we show...
The analysis of genes in evolutionarily distant but morphologically similar species is major importance to unravel the changes genomes over millions years, which led gene silencing and functional diversification. We report Wnt8a expression medakafish provide a detailed comparison other vertebrates. In all teleosts analyzed there are two paralogous copies. These show largely overlapping early developing zebrafish embryo, an relative medaka. contrast zebrafish, we find that both maternal...
Understanding molecular and cellular events influencing the neural progenitor mode of cell division fates daughter cells is central to Developmental Biology. Members cytokinetic machinery have received increasing attention as possible mediators this event: their inheritance or retention appears influence proliferation versus differentiation in cancer stem cells. I therefore took under investigation F‐actin binding protein Anillin, shown be essential for cytokinesis progression completion...