A5035329303- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Retinopathy of Prematurity Studies
- Protein Degradation and Inhibitors
- Tissue Engineering and Regenerative Medicine
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Liver physiology and pathology
- Immune cells in cancer
- CAR-T cell therapy research
- Meningioma and schwannoma management
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA modifications and cancer
- Pancreatic function and diabetes
- Histone Deacetylase Inhibitors Research
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- Viral gastroenteritis research and epidemiology
- Gastrointestinal Tumor Research and Treatment
Ministry of Agriculture and Rural Affairs
2025
Anhui Agricultural University
2025
Washington University in St. Louis
2018-2024
Hebei University
2024
Hunter New England Local Health District
2023
University of Newcastle Australia
2023
Hunter Medical Research Institute
2023
Jewish Hospital
2022
Barnes-Jewish Hospital
2019-2022
Fiona Stanley Hospital
2020
Pancreatic ductal adenocarcinoma (PDAC) therapeutic resistance is largely attributed to a unique tumor microenvironment embedded with an abundance of cancer-associated fibroblasts (CAF). Distinct CAF populations were recently identified, but the phenotypic drivers and specific impact heterogeneity remain unclear. In this study, we identify subpopulation senescent myofibroblastic CAFs (SenCAF) in mouse human PDAC. These SenCAFs are phenotypically distinct subset that localize near ducts...
To study the spatial interactions among cancer and non-cancer cells
Antimicrobial peptides (AMPs) are small that play an important role in disease defense. As the problem of pathogen resistance caused by misuse antibiotics intensifies, identification AMPs as alternatives to has become a hot topic. Accurately identifying using computational methods been key issue field bioinformatics recent years. Although there many machine learning-based AMP tools, most them do not focus on or only few functional activities. Predicting multiple activities antimicrobial can...
Liver regeneration is a complex phenomenon aimed at maintaining constant liver mass in the event of injury resulting loss hepatic parenchyma. Partial hepatectomy followed by series events involving multiple signaling pathways controlled mitogenic growth factors (HGF, EGF) and their receptors (MET EGFR). In addition cytokines other molecules contribute to orchestration signal which drives hepatocytes into DNA synthesis. The cell types receive transmit signals so that, end regenerative...
Exogenous interleukin 6 (IL-6), synthesized at the initiation of acute phase response, is considered responsible for signaling hepatocytes to produce proteins. It widely posited that IL-6 either delivered liver in an endocrine fashion from immune cells site injury, or alternatively, a paracrine manner by hepatic within liver. A recent publication showed there was muted response lipopolysaccharide (LPS)-injured mice when nuclear NFκB specifically inactivated hepatocytes. This indicates...
Abstract The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma (PDAC) are not well understood. To better understand if RT can prime antigen-specific T-cell responses, we analyzed human PDAC tissues and mouse models. In both settings, there was little evidence RT-induced priming. Using vitro systems, found that tumor–stromal components, including fibroblasts collagen, cooperate to blunt efficacy impair interferon signaling. Focal adhesion kinase (FAK)...
Recent investigations of the meninges have highlighted importance dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding largely stems from use pre-clinical models rather than human samples.
Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune checkpoint blockade has improved survival for many patients with NSCLC, but most fail to obtain long-term benefit. Understanding the factors reduced immune surveillance in NSCLC critical improving patient outcomes. Here, we show that human harbors large amounts fibrosis correlates T infiltration. In murine models, induction led increased progression, impaired surveillance, and failure efficacy. Associated...
<p>Supplementary Figure S4. CK5 and CK17 do not predict treatment response or time to recurrence. A) Combining GATA6 IHC does overall survival. B) high, low tumors display improved survival compared low, high tumors. C) Kaplan-Meier curves for positive negative treated with first-line gemcitabine chemotherapy. D) E) status F) show longer recurrence than tumors, the opposite phenotype expected from basal subtype.</p>
<p>Supplementary Figure S1. Example images of IHC FFPE samples. A) HMGA2 positive glands. B) GATA6 Scale bars = 50 μm.</p>
<p>Supplementary Figure S3. Consort Diagram and Mixed Populations. A) diagram of analyzed samples. For survival analyses, all patients with intact cores (n = 491) were assessed. treatment response further subdivided by type chemotherapy received, neoadjuvant-treated samples considered separately 51). B) (HMGA2+ GATA6+) double negative (HMGA2- GATA6-) populations show intermediate between basal classical tumors.</p>
<p>Supplementary Figure S6. GATA6 expression predicts chemotherapy response to GnP but not mFFX. A) GATA6low metastatic tumors have significantly worse overall survival when treated with combination first-line chemotherapy. B) status does predict patients receive first line mFFX chemotherapy.</p>
<div>AbstractPurpose:<p>The purpose of this study was to establish HMGA2 as a marker basal-like disease in pancreatic ductal adenocarcinoma (PDAC) and explore its use biomarker for prognosis treatment resistance.</p>Experimental Design:<p>We identified high-mobility group A2 (HMGA2) protein expression basal PDAC cells single-cell RNA sequencing (RNA-seq) atlas 172 patient samples. We then analyzed expression, along with the classic GATA-binding factor 6 (GATA6),...
<p>Supplementary Figure S5. Representative CD8+ and FAP+ scoring. CD8 (top) FAP (bottom) were scored on a scale of 0 (least staining) to 3 (most following the representative scale.</p>
<p>Supplementary Figure S2. Demographic data for analyzed cohort. A) Age distribution TMA and Ochsner cohorts. B) Race C) Proportions of disease by stage (left) resulting survival (right) predicts in cohort (AJCC 8th edition).</p>
<p>Supplementary Figure S6. GATA6 expression predicts chemotherapy response to GnP but not mFFX. A) GATA6low metastatic tumors have significantly worse overall survival when treated with combination first-line chemotherapy. B) status does predict patients receive first line mFFX chemotherapy.</p>