A5068969298- Fecal contamination and water quality
- Viral gastroenteritis research and epidemiology
- Groundwater flow and contamination studies
- Urban Stormwater Management Solutions
- Child Nutrition and Water Access
- Environmental Justice and Health Disparities
- Smart Materials for Construction
- Soil and Water Nutrient Dynamics
- Salmonella and Campylobacter epidemiology
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Vibrio bacteria research studies
- Mass Spectrometry Techniques and Applications
- Crystal structures of chemical compounds
- Parasitic Infections and Diagnostics
- Otolaryngology and Infectious Diseases
- Alcohol Consumption and Health Effects
- Isotope Analysis in Ecology
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Cytomegalovirus and herpesvirus research
- Lipid metabolism and disorders
- Lipid metabolism and biosynthesis
- Toxoplasma gondii Research Studies
- Constructed Wetlands for Wastewater Treatment
University of Münster
2017-2021
Weston Solutions (United States)
2017-2019
University of California, Davis
2009-2018
UC Davis Comprehensive Cancer Center
2018
Nanyang Technological University
2015
Technical University of Munich
2007
Ludwig-Maximilians-Universität München
2003
We examined pathways of exposure to fecal contamination human and animal origin in 24 villages Odisha, India. In a cross-sectional study during the monsoon season, via community water sources ( N = 123) home 137) was assessed using human- nonhuman-associated Bacteroidales microbial source tracking (MST) markers coliforms (FCs). Detection rates marker concentrations were pinpoint public domestic domains disease transmission communities. Human detected much more frequently domain (45%...
Efforts to eradicate open defecation and improve sanitation access are unlikely achieve health benefits unless interventions reduce microbial exposures. This study assessed human fecal contamination pathogen exposures in rural India, the effect of increased coverage on exposure rates. In a cross-sectional 60 villages cluster-randomized controlled trial Odisha, domestic animal was measured community tubewells ponds (n = 301) via pathways homes 354), using Bacteroidales source tracking markers...
The value of Bacteroidales genetic markers and fecal indicator bacteria (FIB) to predict the occurrence waterborne pathogens was evaluated in ambient waters along central California coast. host-specific quantitative PCR (qPCR) used quantify water provide insights into contributing host sources. Over 140 surface samples from 10 major rivers estuaries within Monterey Bay region were tested over 14 months with four Bacteroidales-specific assays (universal, human, dog, cow), three FIB (total...
We compared host-associated Bacteroidales qPCR assays developed in the continental United States and Europe for purpose of measuring effect improved sanitation on human fecal exposure rural Indian communities where both animal loading are high. Ten candidate were tested against samples (human, sewage, cow, buffalo, goat, sheep, dog chicken) from a test set 30 individual human, 5 60 pooled collected coastal Odisha, India. The two universal/general (BacUni, GenBac3) performed equally well,...
Epigenetic modifications (e.g. DNA methylation) in NAFLD and their contribution to disease progression extrahepatic complications are poorly explored. Here, we use an integrated epigenome transcriptome analysis of mouse hepatocytes identify alterations glyoxylate metabolism, a pathway relevant kidney damage via oxalate release-a harmful waste product stone-promoting factor. Downregulation hypermethylation alanine-glyoxylate aminotransferase (Agxt), which detoxifies glyoxylate, preventing...
Endothelial lipase (LIPG) is a cell surface associated that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). LIPG was recently reported to be expressed breast cancer and support proliferation, tumourigenicity metastasis. Here we show severe oxidative stress leading AMPK activation triggers upregulation, resulting intracellular lipid droplet accumulation cells, which supports survival. Neutralizing abrogated upregulation the...
Marine mammals are at risk for infection by fecal-associated zoonotic pathogens when they swim and feed in polluted nearshore marine waters. Because of their tendency to consume 25-30% body weight per day coastal filter-feeding invertebrates, southern sea otters (Enhydra lutris nereis) can act as sentinels ecosystem health California. Feces from domestic wildlife species were tested determine prevalence, potential virulence, diversity selected opportunistic enteric bacterial the Monterey Bay...
The weak base pyridine has been found to deprotonate trichlorogermane HGeCl3 with quantitative formation of pyridinium trichlorogermanate(II), Py-H+GeCl3−, the pyramidal structure anion resembling that isoelectronic AsCl3 molecule. This course reaction supports assignment an inverse polarization (−)Ge–H(+) bond in as compared (+)Si–H(−) trichlorosilane HSiCl3, which is known form a 1 ∶ 2 adduct instead. Germanium tetrachloride also undergoes simple addition reactions leading ultimately e.g....
Host-associated genetic markers that allow for fecal source identification have been used extensively as a diagnostic tool to determine sources within watersheds, but not in routine monitoring prioritize remediation actions among watersheds. Here, we present regional assessment of human marker prevalence drainages discharge the U.S. southern California coast. Approximately 50 samples were analyzed HF183 from each 22 coastal under summer dry weather conditions, and another targeted 23 during...
Total Maximum Daily Load (TMDL) stipulations remained unmet at a southern California beach despite suite of management actions carried out since 2001, prompting exploration Natural Sources Exclusion (NSE) provision within the TMDL. Quantitative Microbial Source Tracking (MST) was employed from 2012 to 2015 inventory sources natural and anthropogenic fecal indicator bacteria (FIB). Data suggested FIB exceedances could be traced gulls based on gull marker prevalence correlations with...
The aim was to develop an optimized detachment method for separating Bacteroidales from sediments allow enumeration via PMA-qPCR. effectiveness of four different treatments in removing Bacteroides fragilis compared as a function time well relation Enterococcus faecalis and Escherichia coli detected by cultivation qPCR.Cells were inoculated into sea water (SW) freshwater (FW) beaches. Sediment samples taken on days 1 7 subjected separation micro-organisms. On day 1, the performed equally...
Drugs that inhibit cyclooxygenase (COX)-2 and the metabolism of arachidonic acid (ARA) to prostaglandin E2 are potent anti-inflammatory agents used widely in treatment joint muscle pain. Despite their benefits, daily use these drugs has been associated with hypertension, cardiovascular gastrointestinal toxicities. It is now recognized ARA metabolized a number bioactive oxygenated lipids (oxylipins) by (COX), lipoxygenase (LOX), cytochrome P450 (CYP450) enzymes. Currently, contribution...