A5056908352- Origins and Evolution of Life
- Chemical Synthesis and Analysis
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Enzyme-mediated dye degradation
- Enzyme Structure and Function
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Enzyme Catalysis and Immobilization
- Phenothiazines and Benzothiazines Synthesis and Activities
- Click Chemistry and Applications
- Glaucoma and retinal disorders
- Oxidative Organic Chemistry Reactions
- Corneal surgery and disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Protein Structure and Dynamics
- Astro and Planetary Science
- Beetle Biology and Toxicology Studies
- Synthesis and Biological Evaluation
- Scoliosis diagnosis and treatment
- Biochemical and biochemical processes
- Biochemical Analysis and Sensing Techniques
- Multicomponent Synthesis of Heterocycles
Università degli Studi della Tuscia
2015-2024
Viterbo University
2015-2021
University of Siena
2012-2016
Institute of Ophthalmology
2000
The pathway from simple abiotically made organic compounds to the molecular bricks of life, as we know it, is unknown. most efficient geological abiotic route results aqueous dissolution olivine, a reaction known serpentinization (Sleep, N.H., et al. (2004) Proc. Natl. Acad. Sci. USA 101, 12818-12822). In addition hydrogen and reducing environment, reactions lead high-pH alkaline brines that can become easily enriched in silica. Under these chemical conditions, formation self-assembled...
Different catechol and pyrogallol derivatives have been synthesized by oxidation of coumarins with 2-iodoxybenzoic acid (IBX) in DMSO at 25 °C. A high regioselectivity was observed accordance the stability order incipient carbocation or radical benzylic-like intermediate. The also effective water under heterogeneous conditions using IBX supported on polystyrene. new showed improved antioxidant effects DPPH test inhibitory activity against influenza A/PR8/H1N1 virus. These data represent a...
Microcapsules and nanocapsules based on the contemporary presence of sulfonate lignin tannic acid have been prepared by layer-by-layer procedure, using MnCO3 or organosolv as core templates, polydiallyldimethylammonium chloride chitosan positive charged supporting layers. Nanocapsules microcapsules mixed polyphenols showed antioxidant activity, UV-shielding properties, electrochemical responsiveness, higher than that in homopolymer nanocapsule counterparts native polyphenols, suggesting...
It has recently been demonstrated that mineral self-assembled structures catalyzing prebiotic chemical reactions may form in natural waters derived from serpentinization, a geological process widespread the early stages of Earth-like planets. We have synthesized membranes by mixing microdrops metal solutions with alkaline silicate presence formamide (NH2 CHO), single-carbon molecule, at 80 °C. found these bilayer membranes, made amorphous silica and oxide/hydroxide nanocrystals, catalyze...
Recalcitrant sulfur compounds are common impurities in crude oil. During combustion they produce SOx derivatives that able to affect the atmospheric ozone layer, increasing formation of acid rains, and reducing life engine due corrosion. In last twenty years, many efforts have been devoted develop conventional hydrodesulfurization (HDS) procedures, as well alternative methods, such selective adsorption, bio-desulfurization, oxidative desulfurization (ODS) under extractive conditions (ECODS),...
Lignin nanoparticles (LNPs) acted as a renewable and efficient platform for the immobilization of horseradish peroxidase (HRP) glucose oxidase (GOX) by layer procedure. The use concanavalin A molecular spacer ensured correct orientation distance between two enzymes confirmed Förster resonance energy transfer measurement. Layers with different chemo-physical properties tuned in way activity kinetic parameters enzymatic cascade, cationic lignin performing best polyelectrolyte retention optimal...
Abstract We have designed a set of experiments to test the role borosilicate reactor on yielding Miller–Urey type experiment. Two were performed in flasks, two Teflon flask and third couple with pieces submerged water. The CH 4 , N 2 NH 3 atmosphere either buffered at pH 8.7 Cl or unbuffered solutions ca. 11, room temperature. Gas Chromatography-Mass Spectroscopy results show important differences yields, number products, molecular weight. In particular, dipeptide, multi-carbon dicarboxylic...
Abstract The formation of nucleosides in abiotic conditions is a major hurdle origin-of-life studies. We have determined the pathway general reaction leading to one-pot synthesis ribo- and 2′-deoxy-ribonucleosides from sugars purine nucleobases under proton irradiation presence chondrite meteorite. These simulate presumptive space or on an early Earth fluxed by slow protons solar wind, potentially mimicking plausible prebiotic scenario. (i) requires neither pre-activated precursors nor...
Reactive lignin nanocapsules catalyze a pigmentation reaction to furnish an innovative type of sustainable polyvalent bioink. In this nanodevice, the pigment, vehicle, binder, and additive are included in single confined spherical space. Bioinks with different shades color, black, gray, yellow-like, pink-like, red/brown hues, have been prepared by selecting reactants process. Lignin play multiple functions support activation enzyme necessary for synthesis pigments. protected melanin pigment...
This work describes the possibility to combine multicomponent chemistry and multienzymes cascade transformations in a unique reactive framework yield highly functionalized 1,4-benzoxazines under favorable heterogeneous conditions. The synthetic scheme involved generation situ of electrophilic quinone intermediates tyrosol esters catalyzed by lipase M tyrosinase followed nucleophilic 1,6-Michael addition selected α-amino acid methyl esters, successive intramolecular lactonization...
Preventing HIV transmission by the use of a vaginal microbicide is topic considerable interest in fight against AIDS. Both potent anti-HIV agent and an efficient formulation are required to develop successful microbicide. In this regard, molecules able inhibit replication before integration viral DNA into genetic material host cells, such as entry inhibitors or reverse transcriptase (RTIs), ideal candidates for prevention purpose. Among RTIs, S- N-dihydroalkyloxybenzyloxopyrimidines (S-DABOs...
A library of hybrid and dimer compounds based on the natural scaffold artemisinin was synthesized. These derivatives were obtained by coupling derivatives, artesunate, dihydroartemisinin with a panel phytochemical compounds. The novel artemisinin-based hybrids dimers evaluated for their anticancer activity cervical cancer cell line (HeLa) three complementary metastatic melanoma lines (SK-MEL3, SK-MEL24, RPMI-7951). Two artesunate eugenol tyrosol, one containing curcumin, emerged as most...
Immobilization of carbonic anhydrase on SWCNTs by application the CNT binding peptide (CBP) strategy.
Stilbene and chalcone derivatives with biological activity against influenza A virus have been synthesized by self-, cross-, ring-closing metathesis procedures. The reactions were performed under environmentally friendly conditions using the second generation Hoveyda-Grubbs catalyst Aquamet SiPr after immobilization on Santa Barbara Amorphous mesoporous silicate SBA-15. Irrespective from experimental conditions, heterogeneous showed selectivity comparable than homogeneous counterpart for at...
Artesunic acid and artemisinin are natural substances with promiscuous anticancer activity against different types of cancer cell lines. The mechanism action these compounds is associated the formation reactive radical species by cleavage sesquiterpene pharmacophore endoperoxide bridge. Here we suggested topoisomerase 1 as a possible molecular target for improvement compounds. In this context, report that novel hybrid dimer derivatives artesunic artemisinin, bearing camptothecin SN38...
Bio-desulfurization is an efficient technology for removing recalcitrant sulfur derivatives from liquid fuel oil in environmentally friendly experimental conditions. In this context, the development of heterogeneous bio-nanocatalysts great relevance to improve performance process. Here we report that lignin nanoparticles functionalized with concanavalin A are a renewable and platform layer-by-layer immobilization horseradish peroxidase. The novel were applied oxidation dibenzothiophene as...
DOPA peptidomimetics with stable O–C and N–C covalent bonds between amino acid residues have been prepared by aromatic oxidative functionalization of tyrosine 2-iodoxybenzoic (IBX).
Treatment of olive vegetation waste with tyrosinase immobilized on multiwalled carbon nanotubes increased the antioxidant activity as a consequence conversion phenols to corresponding catechol derivatives, evaluated by DPPH, Comet assay, and micronucleus analyses. During this transformation, 4-hydroxyphenethyl alcohol (tyrosol) was quantitatively converted bioactive 3,4-dihydroxyphenethyl (hydroxytyrosol). The hydroxytyrosol-enriched also promoted autophagy inhibited inflammatory response in...
Amino imidazole carbonitrile derivatives decorated with α-amino acid side-chains have been synthesized by a multicomponent microwave assisted reaction inspired the prebiotic chemistry of aminomalononitrile for generating high chemical diversity.
Abstract Amino acid decorated imidazole, pyrimidine and purine derivatives, resembling analogues of peptide nucleic acid's building blocks, have been synthesized by a three‐way multicomponent chemistry diaminomaleonitrile, one the most studied chemical precursors in prebiotic chemistry. The regioselectivity reaction between trimethyl orthoacetate selected panel α‐amino acids, was controlled energy source used for triggering condensation. Imidazole derivatives were obtained under thermal...
DOPA-derived peptidomimetics are an attractive therapeutic tool for the treatment of Parkinson's disease.