A5053596937- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- Eosinophilic Esophagitis
- Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Microscopic Colitis
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Bariatric Surgery and Outcomes
- Ureteral procedures and complications
Iwate Medical University
2010-2023
Japanese Red Cross Hadano Hospital
2015
There have been some descriptions of dabigatran-induced esophagitis in the literature. The aim this study was to examine prevalence and endoscopic characteristics disease.We reviewed database medical records 91 patients with dabigatran internal use who underwent upper gastrointestinal endoscopy. frequency its findings were retrospectively analyzed. In addition, clinical compared between those without disease.Dabigatran-induced found 19 (20.9%) patients. Of esophagitis, 18 (94.7%) showed...
Background Circulating tumor DNA (ctDNA) carries information on burden. However, the mutation spectrum is different among tumors. This study was designed to examine utility of ctDNA for monitoring burden based an individual profile. Methodology extracted from a total 176 samples, including pre- and post-operational plasma, primary tumors, peripheral blood mononuclear cells (PBMC), 44 individuals with colorectal who underwent curative resection as well nine healthy individuals. Using panel 50...
Colonic mucosa-associated lymphoid tissue (MALT) lymphomas are rare and a definitive treatment has not been established. Solitary or multiple, elevated polypoid lesions the usual appearances of MALT lymphoma in colon sometimes surface may reveal abnormal vascularity. In this paper we report our experience with four cases colonic review relevant literature. The first patient had smooth lesion rectum histopathologic examination biopsy from showed centrocyte-like cells infiltrating lamina...
To better understand progressive changes in gastric cancer (GC), early and advanced GCs (EGC AGC, respectively) were examined for copy number alterations (CNAs). A crypt isolation method was used to isolate DNA from tumors normal glands 20 AGCs, fresh tumor samples obtained 45 EGCs. We assessed CNAs differentiated-type using an Infinium HumanCytoSNP-12v2.1 BeadChip EGCs AGCs. The most frequent aberrations EGC gains at 8q23.3 (42.2%) 8q23.2 (40%), loss of heterozygosity (LOH) 3p14.2 (24.2%),...
Identification of the molecular characteristics intramucosal (IMCs) and submucosal cancers (SMCs) is essential to our understanding early gastric carcinogenesis. However, little known regarding differences between 2 lesions. One hundred forty-eight patients with primary cancer [IMC, 106; SMC, 42] were characterized for expression cell cycle-related proteins loss heterozygosity (LOH). We also examined microsatellite instability (MSI) methylation status. For LOH studies, we used a panel 17...
To determine appropriate fecal calprotectin cut-off values for the prediction of endoscopic and histologic remission in Japanese patients with ulcerative colitis (UC).We performed a cross-sectional observational study 131 UC measured levels by fluorescence enzyme immunoassay. The clinical activity was assessed partial Mayo score (PMS). Relapse defined as increase PMS 2 points or more stool frequency rectal bleeding subscore. activities were evaluated 50 within 2-mo period from sampling....
We aimed to investigate an association between clinicopathological features, including immunohistochemical mucin phenotypes, and magnifying chromoendoscopic findings with crystal violet staining (ME-CV) in non-ampullary duodenal epithelial tumors (NADETs).A total of 55 patients NADET were divided into 3 groups by phenotype: intestinal, gastrointestinal, or gastric. ME-CV classified 4 patterns: convoluted, leaf-like, reticular/sulciolar, pinecone. The features compared among the...
We reviewed the records of patients with immune checkpoint inhibitor (ICI)‐induced diarrhea during 2015 to 2019. ICI included nivolumab and ipilimumab. There were 11 ICI‐induced aged 46–81 years (median, 63 years). On colonoscopy, four appeared normal, whereas loss vascularity, erythema, granularity, erosions or ulcerations apparently mimicking ulcerative colitis found in seven patients. Those had acute inflammation, cryptitis, crypt abscess apoptosis, suggestive colitis. Five treated...
Abstract Colorectal cancers (CRCs) exhibit multiple genetic alterations, including allelic imbalances (copy number CNAs) at various chromosomal loci. In addition to aberrations, DNA methylation also plays important roles in the development of CRC. To better understand clinical relevance these and epigenetic abnormalities CRC, we performed an integrative analysis copy changes on a genome‐wide scale assessed mutations TP53 , KRAS BRAF PIK3CA six marker genes single glands isolated from 39...
Underwater endoscopic mucosal resection (U-EMR) has been attracting much attention as treatment for patients with nonampullary duodenal epithelial tumors (NADETs). We aim to compare outcomes, including submucosal resectability, between undergoing U-EMR and conventional (C-EMR) NADET.We conducted a retrospective review of 38 NADET treated by or C-EMR. In the resected specimens, we measured horizontal length, vertical distance from muscularis mucosa margin at deepest site, overall area. The...
Tumor tissue consists of a heterogeneous cell population. The allelic imbalance ( AI ) ratio, determined in isolated tumor glands, is good index heterogeneity. However, associations the patterns and microsatellite instability MSI development, observed most cases colorectal cancer CRC ), with progression have not been reported previously. In this study, we examined whether genetic profiles stratified by combination ratio facilitate categorization , these are associated specific molecular...
Objectives Little is known about the usefulness of magnifying endoscopy with crystal violet staining (ME‐CV) for diagnosis duodenal tumors. We assessed ability ME‐CV to distinguish Vienna classification (VCL) category 4/5 (C4/5) from 3 (C3) non‐ampullary epithelial tumors (NADETs). Methods A total 76 NADETs were studied. retrospectively analyzed diagnostic values white light (WLE) scoring system and algorithm receiver operating characteristic (ROC) curves, three endoscopists calculated...
Objective Indigo naturalis (IN) is a traditional Chinese medicine that has recently been reported to be effective for ulcerative colitis (UC). The aim of this study was evaluate the efficacy and safety IN.
Background/Aims Magnifying endoscopic classification systems, such as the Japan narrow-band imaging (NBI) Expert Team (JNET) classification, have been widely used for predicting histologic diagnosis and invasion depth of colorectal epithelial tumors. However, disagreement exists among observers regarding magnifying diagnosis, because these systems are subjective. We herein investigated utility microvascular density (eMVD) calculated from NBI images in Methods reviewed 169 tumors (97...
Follicular lymphomas occur rarely in the gastrointestinal tract, representing only 1–3% of all tract B-cell non-Hodgkin lymphomas. We describe endoscopic analysis 3 cases follicular lymphoma small intestine using double-balloon endoscopy. Double-balloon endoscopy revealed multiple nodular lesions and elevated white patches, polypoid lesions, scattered duodenum intestine. Fuji Intelligent Chromo Endoscopy demonstrated small, whitish nodules, narrow-band imaging showed a coiled, elongated...
Abstract Background Clinical outcomes and prognostic factors for survival after endoscopic submucosal dissection (ESD) in older patients aged ≥ 85 years with early gastric cancer (EGC) are not well defined. The aim of this study was to investigate the clinical ESD EGC. Methods 70 EGC treated were evaluated retrospectively. Prognostic overall (OS) analyzed Kaplan–Meier method a Cox proportional hazards model. Results During follow-up period, 33 died from any cause, none whom cancer. OS...
Abstract Background Crawling-type adenocarcinoma (CRA) is an important gastric cancer (GC) subtype that exhibits a specific histological pattern and has characteristic clinicopathological findings. Despite its histology, little known about the molecular characteristics of CRA. Methods We examined 177 GC cases, including 51 cases CRA 126 having conventional differentiated adenocarcinomas (CDAs). Results for immunohistochemistry (mucin phenotype; Muc5AC, Muc6, Muc2 CD10, CDX-2, MLH-1, p53...
To examine the association between white opaque substance (WOS) and histologically verified lipid droplets in colorectal epithelial neoplasms.We reviewed colonoscopy records at our institution from 2014 to 2016 identified cases of endoscopically or surgically resected neoplasms observed by magnifying narrow-band imaging (M-NBI) colonoscopy. Immunohistochemistry was used stain tumors with a monoclonal antibody specific adipophilin as marker lipids. The expression distribution were compared...
Infliximab (IFX) has been reported to be useful as induction therapy and/or maintenance for Crohn's disease (CD). However, the effects of IFX on serial changes in cytokine levels have not well characterized. We examined CD patients before and after administration IFX.A total 37 with active were enrolled (24 men, 13 women; mean age, 31.9 years). Patients given 5mg/kg intravenously. Serum 17 cytokines simultaneously determined using a Bio-Plex suspension array system treatment and, 4 8 weeks...
Epstein-Barr virus-associated gastric cancer (EBVGC) has been reported to be associated with a low risk for lymph node metastasis (LNM). However, the curative criteria endoscopic submucosal dissection (ESD) EBVGC (pT1b-EBVGC) remain unclear. Our study aimed investigate factors LNM in pT1b-EBVGC.This was retrospective multicenter at five institutes Japan. We reviewed medical records and extracted all pT1b-EBVGC cases that met following criteria: (i) histologically proven cancer; (ii) surgical...