A5048931275- Multiple Sclerosis Research Studies
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Schizophrenia research and treatment
- Healthcare Decision-Making and Restraints
- Maternal Mental Health During Pregnancy and Postpartum
- Anesthesia and Neurotoxicity Research
- Diabetes Treatment and Management
- Infant Development and Preterm Care
- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- Systemic Sclerosis and Related Diseases
- Polyomavirus and related diseases
- Hereditary Neurological Disorders
- Acute Lymphoblastic Leukemia research
- Radiomics and Machine Learning in Medical Imaging
- Tryptophan and brain disorders
- Genetic Neurodegenerative Diseases
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Peripheral Neuropathies and Disorders
- Family and Patient Care in Intensive Care Units
- RNA regulation and disease
- Takotsubo Cardiomyopathy and Associated Phenomena
- Mycobacterium research and diagnosis
St. Michael's Hospital
2018-2024
University of Toronto
2011-2024
St Michael’s Hospital
2022-2023
Unity Health Toronto
2022-2023
Mount Sinai Hospital
2015-2021
Sunnybrook Health Science Centre
2017-2020
Health Sciences Centre
2017-2020
St Michaels Hospital
2020
Neurology, Inc
2019
Laboratoire de Chimie
2018
Paramagnetic Rim Sign in Radiologically Isolated SyndromeIndividuals with radiologically isolated syndrome (RIS) have incidental magnetic resonance imaging (MRI) abnormalities suggestive of multiple sclerosis (MS). 1 Recent studies using susceptibility-based shown that a subgroup chronic MS white matter lesions (WMLs) rim paramagnetic susceptibility-associated signal loss at the lesion edge, sign (PRS), is associated presence iron inside phagocytes, which indicates chronic, active...
Objective: The central vein sign (CVS) and “paramagnetic rim lesions” (PRL) are emerging imaging biomarkers in multiple sclerosis (MS) reflecting perivenular demyelination chronic, smoldering inflammation. objective of this study was to assess relationships between cognitive impairment (CI) the CVS PRL radiologically isolated syndrome (RIS). Methods: Twenty-seven adults with RIS underwent 3.0 T MRI brain cervical spinal cord (SC) assessment using minimal function MS battery. were assessed...
<h3>BACKGROUND AND PURPOSE:</h3> Radiologically isolated syndrome describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis. Recent studies have demonstrated that >40% white matter lesions in MS (and often substantially more) visible central veins on MR imaging. This "central vein sign" reflects perivenous inflammatory demyelination and can assist differentiating from other disorders. We therefore hypothesized cases radiologically would...
Antipsychotics (APs) are linked to diabetes, even without weight gain. Whether anti-diabetic drugs efficacious in reversing the direct effects of APs on glucose pathways is largely undetermined. We tested two metformin (Met) doses prevent impairments seen following a dose olanzapine (Ola) (3 mg/kg); glucokinetics were measured using hyperinsulinemic-euglycemic clamp (HIEC). Met (150 mg/kg; n=13, or 400 n=11) vehicle (Veh) (n=11) was administered through gavage preceding an overnight fast,...
Background: There are no specific, evidence-based recommendations for the management of individuals with radiologically isolated syndrome. Imaging and blood biomarkers may have prognostic utility. Objective: To determine whether plasma neurofilament light protein (NfL) or glial fibrillary acidic (GFAP) levels in people syndrome correlate imaging measures that been shown to be associated negative clinical outcomes multiple sclerosis. Methods: Cross-sectional analysis Participants underwent...
Introduction Delirium is highly prevalent in the intensive care unit (ICU) and associated with adverse clinical outcomes. At this time, there no drug that effectively prevents delirium critically ill patients. Alterations melatonin secretion metabolism may contribute to development of delirium. Administration exogenous has been shown prevent non-critically surgical medical This trial will demonstrate feasibility a planned multicentre, randomised controlled test hypothesis can patients...
Restraining therapies (physical or pharmacological) are used to promote the safety of both patients and health care workers. Some guidelines recommend nonpharmacological pharmacological interventions be before physical restraints in critically ill patients.To characterize psychotropic drug after use adults receiving mechanical ventilation.A single-center, prospective, observational study documenting Sedation-Agitation Scale (SAS) scores 2 hours 6 application restraints.Ninety-three were...
Abstract Background Neurological disability progression occurs across the spectrum of people living with multiple sclerosis (MS). Although there are a handful disease-modifying treatments approved for use in progressive phenotypes MS, no that substantially modify course clinical MS. Characterizing determinants can inform development novel therapeutic agents and treatment approaches target which is one greatest unmet needs practice. Canada, having world’s highest rates MS publicly-funded...