A5056319305- Antimicrobial Peptides and Activities
- Venomous Animal Envenomation and Studies
- Biochemical and Structural Characterization
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Lipid Membrane Structure and Behavior
- Microbial metabolism and enzyme function
- Microbial Community Ecology and Physiology
- Nicotinic Acetylcholine Receptors Study
- Wastewater Treatment and Nitrogen Removal
- Microbial bioremediation and biosurfactants
- Water Treatment and Disinfection
- Total Knee Arthroplasty Outcomes
- Biofuel production and bioconversion
- Surgical site infection prevention
- Methane Hydrates and Related Phenomena
University of Hull
2019-2023
Sheffield Hallam University
2013-2018
Lipid coated liquid crystal droplets have been trapped in a novel trap structure for the on-chip detection of model antimicrobial peptide – Smp43, an α-helical from Scorpion Venom.
Tantalum (Ta) trabecular metal components are increasingly used to reconstruct major bone defects in revision arthroplasty surgery. It is known that some metals such as silver have antibacterial properties. Recent reports raised the question regarding whether Ta protective against infection This laboratory study aimed establish has intrinsic properties planktonic bacteria, or ability inhibit biofilm formation.Equal-sized pieces of and titanium (Ti) acetabular were sterilised incubated with a...
The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for development effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted great deal attention as possible solution to increasing problem antibiotic-resistant bacteria. Marcin-18 was identified from scorpion Mesobuthus martensii at both DNA and protein levels. genomic sequence revealed that marcin-18 coding gene contains phase-I intron with GT-AG splice junction...
Understanding the mechanism of action antimicrobial peptides (AMP) is fundamental to development and design peptide based antimicrobials. Utilizing fast-scan atomic force microscopy (AFM) we detail attack an AMP on both prototypical prokaryotic (DOPC:DOPG) eukaryotic (DOPC:DOPE) model lipid membranes nanoscale in real time. Previously shown have a favourable therapeutic index, study Smp43, with helical-hinge-helical topology isolated from venom North African scorpion Scorpio maurus palmatus....
Determining the mechanism of action antimicrobial peptides (AMPs) is critical if they are to be developed into clinical setting. In recent years high resolution techniques such as atomic force microscopy (AFM) have increasingly been utilised determine AMP on planar lipid bilayers and live bacteria. Here we present biophysical characterisation a prototypical from venom North African scorpion Scorpio maurus palmatus termed Smp24. Smp24 an amphipathic helical peptide containing 24 residues with...
Methane is a potent greenhouse gas, which has contributed to approximately fifth of global warming since pre-industrial times. The agricultural sector produces significant methane emissions, especially from livestock, waste management and rice cultivation. Rice fields alone generate around 9% total anthropogenic emissions. produced in waterlogged paddy by methanogenic archaea, transported the atmosphere through aerenchyma tissue plants. Thus, bioengineering with catalysts detoxify en route...
ObjectivesTo assess the performance of Gram-negative-specific antibiotic temocillin in polymethylmethacrylate bone cement pre-loaded with gentamicin, as a strategy for local delivery.