A5008498939- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- RNA regulation and disease
- Photoreceptor and optogenetics research
- Calcium signaling and nucleotide metabolism
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- RNA Research and Splicing
- Cellular transport and secretion
- Spaceflight effects on biology
- RNA and protein synthesis mechanisms
- Olfactory and Sensory Function Studies
- Cancer, Stress, Anesthesia, and Immune Response
- HER2/EGFR in Cancer Research
- thermodynamics and calorimetric analyses
- Neuroscience and Neural Engineering
- Nitric Oxide and Endothelin Effects
- Connexins and lens biology
- Neuroendocrine regulation and behavior
- Eicosanoids and Hypertension Pharmacology
- Cancer Treatment and Pharmacology
- Cardiac electrophysiology and arrhythmias
- Advanced Breast Cancer Therapies
Henan Cancer Hospital
2025
Zhengzhou University
2025
UConn Health
2017-2024
University of Connecticut
2020-2023
Farmington Community Library
2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in and the fusion synaptic vesicles containing neurotransmitter. Presynaptic output is a function density channels, dynamic properties channel, distance docked vesicles, release probability docking site. We demonstrate that Caenorhabditis elegans neuromuscular junctions two different classes CaV2 CaV1, mediate distinct pools vesicles. are concentrated densely packed clusters ~250 nm diameter with...
This study aimed to evaluate the efficacy and safety of docetaxel rechallenge in HER2-negative metastatic breast cancer (MBC) patients who discontinued for reasons other than disease progression. We retrospectively analyzed MBC treated with docetaxel-based therapy (DBT) at our institution from 2010 2020. Objective response rate (ORR), progression-free survival (PFS), overall (OS), adverse events (AEs) were assessed. Multivariate Cox regression propensity score matching analysis (PSMA) used...
Melatonin is known to promote sleep, but its underlying molecular mechanisms remain poorly understood. Using CBA/CaJ mice, a strain capable of melatonin synthesis, we explored the roles BK channel (Slo1) and receptor MT1 in regulating sleep behavior action potentials suprachiasmatic nucleus (SCN). Global knockout Slo1 or reduced REM NREM increased wakefulness, broadened while abolishing afterhyperpolarization SCN neurons. These effects were primarily exclusively observed during subjective...
Electrical signaling across distinct populations of brain cells underpins cognitive and emotional function; however, approaches that selectively regulate electrical between two cellular components a mammalian neural circuit remain sparse. Here, we engineered an synapse composed connexin proteins found in Morone americana (white perch fish), connexin34.7 connexin35, to accomplish modulation. By exploiting protein mutagenesis, devising new vitro system for assaying hemichannel docking,...
Significance Melatonin (Mel) promotes sleep through G protein-coupled Mel receptors. However, the downstream molecular target(s) of receptors to produce effect remains enigmatic. The study shows that a potassium channel, BK plays role in and by activating this channel specific receptor.
Precise synaptic connection of neurons with their targets is essential for the proper functioning nervous system. A plethora signaling pathways act in concert to mediate precise spatial arrangement connections. Here we show a novel role gap junction protein controlling tiled GABAergic motor Caenorhabditis elegans , which axons and synapses overlap minimally neighboring within same class. We found that while EGL-20/Wnt controls axonal tiling, presynaptic tiling mediated by UNC-9/Innexin,...
Abstract Locomotor activities can enhance learning, but the underlying circuit and synaptic mechanisms are largely unknown. Here we show that locomotion facilitates aversive olfactory learning in C. elegans by activating mechanoreceptors motor neurons, transmitting proprioceptive information thus generated to interneurons through antidromic-rectifying gap junctions. The serves regulate experience-dependent functional coupling of process sensory produce behavior. Genetic destruction either...
Slo2 potassium channels play important roles in neuronal function, and their mutations humans may cause epilepsies cognitive defects. However, it is largely unknown how regulated by other proteins. Here we show that the function of C. elegans (SLO-2) depends on adr-1, a gene to RNA editing. ADR-1 promotes SLO-2 not editing transcripts slo-2 but those scyl-1, which encodes an orthologue mammalian SCYL1. Transcripts scyl-1 are greatly decreased adr-1 mutants due deficient at single adenosine...
Comparative analyses of locomotor behavior and cellular electrical properties between wild-type mutant
Synaptic configurations underpin how the nervous system processes sensory information to produce a behavioral response. This is best understood for chemical synapses, and we know far less about electrical synaptic modulate processing context-specific behaviors. We discovered that innexin 1 (INX-1), gap junction protein forms required deploy strategies underlying thermotaxis behavior in C. elegans. Within this well-defined circuit, INX-1 couples two bilaterally symmetric interneurons...
Abstract Synaptic configurations in precisely wired circuits underpin how sensory information is processed by the nervous system, and emerging animal behavior. This best understood for chemical synapses, but far less known about electrical synaptic modulate, vivo specific neurons, processing context-specific behaviors. We discovered that INX-1, a gap junction protein forms required to deploy behavioral strategies during C. elegans thermotaxis INX-1 couples two bilaterally symmetric...
Auxiliary subunits are often needed to tailor K+ channel functional properties and expression levels. Many auxiliary have been identified for mammalian Slo1, a high-conductance gated by voltage Ca2+. Experiments with heterologous systems show that some of the Slo1 can also regulate other Slo channels. However, it is unclear whether single subunit may more than one in native tissues. BKIP-1, an C. elegans SLO-1, facilitates SLO-1 membrane trafficking regulates function neurons muscle cells....
Synaptic configurations in precisely wired circuits underpin how the nervous system processes sensory information to produce a behavioral response. While this is best understood for chemical synapses, we know far less electrical synaptic specified neural vivo modulate processing and context-specific behaviors. We discovered that INX-1, gap junction protein forms required deploy strategies underlying thermotaxis behavior C. elegans. Within well-defined circuit, INX-1 couples two bilaterally...
Abstract Slo2 potassium channels play important roles in neuronal function, and their mutations humans cause epilepsies cognitive defects. However, little is known how function regulated by other proteins. Here we found that the of C. elegans (SLO-2) depends on adr-1 , a gene to RNA editing. slo-2 transcripts have no detectable editing events exhibit similar expression levels wild type mutants. In contrast, mRNA level scyl-1 which encodes an orthologue mammalian SCYL1, greatly reduced...
Abstract Precise synaptic connection of neurons with their targets is essential for the proper functioning nervous system. A plethora signaling pathways act in concert to mediate precise spatial arrangement connections. Here we show a novel role gap junction protein controlling tiled GABAergic motor C. elegans , which axons and synapses overlap minimally neighboring within same class. We found that while EGL-20/Wnt controls axonal tiling, presynaptic tiling mediated by UNC-9/Innexin,...