A5101866989- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Chinese history and philosophy
- Kruppel-like factors research
- Plant Pathogens and Fungal Diseases
- Congenital heart defects research
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Prostate Cancer Treatment and Research
- Food Safety and Hygiene
- Microtubule and mitosis dynamics
- Phytochemical compounds biological activities
- Fungal Biology and Applications
- RNA Research and Splicing
- Antibiotic Resistance in Bacteria
- Tannin, Tannase and Anticancer Activities
- Protein Degradation and Inhibitors
- Inflammatory Biomarkers in Disease Prognosis
- Pineapple and bromelain studies
- Antibiotic Use and Resistance
Dalian Medical University
2015-2024
First Affiliated Hospital of Dalian Medical University
2015-2024
Suzhou Municipal Hospital
2021
Hangzhou First People's Hospital
2015
Zhejiang Chinese Medical University
2015
University of South China
2015
First Affiliated Hospital of University of South China
2015
China Medical University
2012-2014
First Hospital of China Medical University
2014
Kansas State University
2003-2007
Abstract Background Emerging evidence has shown that dysregulated expression of long noncoding RNAs (lncRNAs) is implicated in liver hepatocellular carcinoma (HCC). However, the role and molecular mechanism differentially expressed lncRNAs HCC not been fully explained. Methods The profiles samples were derived from microarrays analysis or downloaded Cancer Genome Atlas (TCGA), their correlation with prognosis clinical characteristics further analyzed. Silencing lncRNA ZFPM2-AS1 was conducted...
Abstract Hepatocellular carcinoma (HCC) is a common malignant tumor that severely threatens human health. The poor prognosis of HCC mainly attributed to intrahepatic and extrahepatic metastases. HOXD9 proteins belong superfamily regulates the development control many cellular processes, including proliferation, apoptosis, cell shape, migration. can also function as an oncogene in several cancer cells. However, its biological requires further investigation. In this study, exhibited high...
ATAD2 is associated with many cellular processes, such as cell growth, migration and invasion. However, no studies have been conducted on the molecular biological function of gene in hepatocellular carcinoma (HCC).The protein mRNA level expression was examined tissues lines. Prognostic significance analyzed by Kaplan-Meier survival method Cox regression. knockdown used to analyze proliferation The upstream downstream RT2 Profiler™ PCR array luciferasex fluorescence system.ATAD2 highly...
Eukaryotic initiation factor 4G (eIF4G) promotes mRNA recruitment to the ribosome by binding cap- and poly(A) tail-binding proteins eIF4E Pap1p. eIF4G also binds eIF4A at a distinct HEAT domain composed of five stacks antiparallel alpha-helices. The role in later steps initiation, such as scanning AUG recognition, has not been defined. Here we show that entire flanking residues Saccharomyces cerevisiae eIF4G2 are required for optimal interaction with recognition factors eIF5 eIF1. eIF1...
To investigate the in vitro and vivo antibacterial activities of tigecycline other 13 common antimicrobial agents, alone or combination, against multi-drug resistant Acinetobacter baumannii.An susceptibility test 101 A. baumannii was used to detect minimal inhibitory concentrations (MICs). A mouse lung infection model baumannii, established by ultrasonic atomization method, define activities.Multi-drug showed high sensitivity (98% inhibition), polymyxin B (78.2% minocycline (74.2%...
Liver cancer in men is the fifth most frequently diagnosed worldwide. Human Krüppel-like factor (KLF9) gene, localized on human chromosome 9q13, has been implicated mediating a diverse range of biological processes including stem cell maintenance and differentiation T- B-lymphocytes. In this study, we confirmed that levels KLF9 mRNA protein were lower hepatocellular carcinoma (HCC) tissue compared to normal tissue. addition, upregulation inhibited proliferation mobility induce apoptosis...
Liver cancer is the fifth most frequently diagnosed type of in men worldwide. Recombinant human programmed cell death 5 (rhPDCD5) has been shown to enter a variety cells by clathrin-independent endocytosis. Tissue specimens from 32 hepatocellular carcinoma (HCC) patients were collected for analysis PDCD5 expression using ELISA. It was confirmed that pre‑operative serum levels protein with HCC significantly lower than post‑operative levels. Moreover, correlated portal invasion and lymph node...
Objective To identify a rapid and efficient fungal genomic DNA extraction method for PCR amplification. Methods Genomic was extracted from Penicillum marneffei, Rhizopus microsporus, Cryptococcus neoformans Candida albicans by heating pyrolysis, microwave, repeated freezing thawing, lysozyme digestion, overnight snail enzymatic Qiagen kit methods. electrophoretogram observed gel imaging system. The concentration purity of were determined with an ultramicro nucleic acid protein tester...
Abstract It is widely accepted that tumor metastasis the dominant factor leading to cancer-related death. Tumor mediated by cell invasion, blood circulation and lymphatic circulation. Paclitaxel, as a common anti-tumor drug mitotic inhibitor, promotes microtubule assembly inhibits depolymerization. In addition, ticagrelor, an anti-platelet drug, used treat acute coronary syndrome. An increasing numbers of studies have reported platelets can facilitate metastasis. Therefore, inhibiting...