A5034618812- Fungal Infections and Studies
- Nanoparticles: synthesis and applications
- Essential Oils and Antimicrobial Activity
- Fungal Biology and Applications
- Antifungal resistance and susceptibility
- Natural product bioactivities and synthesis
- Microbial Community Ecology and Physiology
- Probiotics and Fermented Foods
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Ziziphus Jujuba Studies and Applications
- Genetic and phenotypic traits in livestock
- Selenium in Biological Systems
- Herbal Medicine Research Studies
- Mechanical Circulatory Support Devices
- Aquaculture disease management and microbiota
- Bee Products Chemical Analysis
- Cardiac Structural Anomalies and Repair
- Phytochemical compounds biological activities
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Neuroprotection
- Phytochemistry and Bioactivity Studies
- Nail Diseases and Treatments
- Parasitic Infections and Diagnostics
- Genomics and Phylogenetic Studies
Al-Azhar University
2016-2025
Al-Azhar University
2023
Arabian Gulf University
2023
ORCID
2021
Virginia–Maryland College of Veterinary Medicine
2019-2020
University of Maryland, College Park
2019-2020
Michigan Medicine
2016-2018
VA Ann Arbor Healthcare System
2016-2018
Cairo University
2016-2018
University of Michigan
2016
Fungal dissemination into the bloodstream is a critical step leading to invasive fungal infections. Here, using intravital imaging, we show that Kupffer cells (KCs) in liver have prominent function capture of circulating Cryptococcus neoformans and Candida albicans, thereby reducing target organs. Complement C3 but not C5, complement receptor CRIg CR3, are involved C. neoformans. Internalization by KCs subsequently mediated multiple receptors, including CRIg, scavenger which work...
The emergence of bacteria that are resistant to several antibiotics has represented a serious hazard human health globally. Bioactive metabolites from medicinal plants have wide spectrum therapeutic possibilities against bacteria. Therefore, this study was performed investigate the antibacterial efficacy various extracts three as Salvia officinalis L., Ziziphus spina-christi and Hibiscus sabdariffa L. pathogenic Gram-negative Enterobacter cloacae (ATCC13047), Pseudomonas aeruginosa...
Abstract The current study was performed to evaluate the bioactivity of banana wastes against some bacterial and fungal isolates, organic acids production, antioxidant screen phytochemicals were present in Musa acuminate (M. acuminate) wastes. waste processed by microbial species. evaluated yield using HPLC. Antioxidant impact tested DPPH assay. Qualitative analysis for done after each treatment. M. (Banana) extracts showed moderate effect growth microorganisms while this became much better...
Significance Bloodborne parasites develop very sophisticated mechanisms to survive in the bloodstream, causing serious diseases. The involved intravascular clearance of bloodborne are largely unknown. Understanding underlying is fundamental for developing strategies treat In current study, we reveal that CRIg, a macrophage receptor previously shown bind C3b/iC3b vitro, plays an essential role African trypanosomes. More importantly, demonstrate through interactions with complement deposited...
Z. coccineum is a facultative plant with many medicinal applications. This study examined the anti-inflammatory activity of Zygophyllum (Z. coccineum) in an arthritis animal model.Seventy-Six Wistar Albino rats either sex randomly divided into six groups (12/each). The inflammation model was done using Complete Freund's Adjuvant albino rats. activities extract were estimated at different dose levels (15.6, 31, and 60 mg/kg) as well upon methotrexate (MTX) standard drug (0.3 mg/kg). Paw...
Abstract This study developed an integrated wastewater treatment system that combines upflow anaerobic sludge blanket (UASB), downflow hanging non-woven fabric (DHNW), and baffled reactor (ABR) to explore the effect of stages on diversity microeukaryotic communities. aimed bridge knowledge gap regarding influence community diversity. Through 18S rRNA amplicon sequencing, we identified unique communities across different stages, with aerobic phase hosting 35.77% sequence variants (ASVs). The...
In this study we extracted bioactive ingredients from fruiting bodies of Laetiporus sulphureus with different solvents and tested the antimicrobial antitumor activities. The predominant lipid composition was studied GC–MS revealed a high amount oleic acid, octadecenoic acid ergosterol derivatives. Extracts L. were shown to have activity against all fungal strains including Candida albicans, Geotrichum candidum, Aspergillus fumigatus, niger, Curvularia clavata, Fusarium oxysporum, as well...
Monocytes exist in two major populations, termed Ly6Chi and Ly6Clow monocytes. Compared to monocytes, less is known about monocyte recruitment mechanisms involved the of this subset. Furthermore, role monocytes during infections largely unknown. Here, using intravital microscopy, we demonstrate that are predominantly recruited brain vasculature following intravenous infection with Cryptococcus neoformans, a fungal pathogen causing meningoencephalitis. The depends primarily on interaction...
The perennial plant
ABSTRACT Anti-tumor necrosis factor alpha (anti-TNF-α) therapies have been increasingly used to treat inflammatory diseases and are associated with increased risk of invasive fungal infections, including Cryptococcus neoformans infection. Using a mouse model cryptococcal infection, we investigated the mechanism by which disruption early TNF-α signaling results in development nonprotective immunity against C. . We found that transient depletion inhibited pulmonary clearance enhanced...
Saussurea costus is a medicinal plant with different bioactive compounds that have an essential role in biomedicine applications, especially Arab nations. However, traditional extraction methods for oils can lead to the loss of some volatile and non-volatile oils. Therefore, this study aimed optimize supercritical fluid (SFE) from S. at pressures (10, 20, 48 MPa). The results were investigated by GC/MS analysis. MTT, DPPH, agar diffusion assessed extracted oils’ anticancer, antioxidant,...
The present study was aimed at investigating the possible antiulcer activities of some natural phytochemicals Aloe perryi leaf extract (APLE) and flower (APFE) in addition to date palm seed (DPSE) oily samples DPSE a pylorus ligation-induced ulcer model using ranitidine as standard drug.Peptic is prevalent gastrointestinal disorder due hypersecretion gastric acid. It affects four million people worldwide, 2-10% these ulcers are perforated cause bleeding. This increases risk morbidity...
Tellurium has received substantial attention for its remarkable properties. This study performed in vitro and vivo testing of the antibacterial action tellurium nanoparticles biosynthesized actinomycetes against methicillin-resistant Staphylococcus aureus (MRSA), a common blood bacterial pathogen.Nine actinomycete isolates were tested their potential to reduce potassium tellurite (K2TeO3) form (TeNPs). The most efficient isolate producing Tellerium was identified through molecular protocols....
This work was undertaken to investigate the effect of different dose levels gamma irradiation ranged from 0.2 1 kGy on Metarhizium anisopliae lipase, protease, amylase and nitrate reductase activities. The optimum results obtained with a level 0.4 which stimulated maximum enzymatic Titanium nanoparticles (TiNPs) were mycosynthesized using unirradiated irradiated (0.4 KGy) M. characterized UV–Vis spectrophotometry, electron microscopy (TEM) energy-dispersive spectrometry (EDX). In addition,...
Limited attention is devoted to the improvement of quality life patients suffering from negative consequences Sickle cell disease (SCD). Our study focuses on evaluation performance WHOQOL-BREF as a tool measure SCD Patients in Bahrain.We conducted cross-sectional that enrolled 273 selected using simple random sampling technique primary health-care centers Bahrain 2019. A designed questionnaire including was filled by health centers. The reliability assessed standardized Cronbach's alpha...
We applied biosynthesized titanium and selenium nanoparticles, prepared using a fungal water extract of Trichoderma harzianum (T. harzianum), to eradicate tomota wilt infection. Transmission electron microscopy (TEM), Scanning (SEM), Energy Dispersive X-Ray analysis, microscopy/X-ray diffraction (TEM/XRD) techniques were used characterize the spherical metal whose diameters 16.0 nm for nanoparticles (SeNPs) 50.0 (TiNPs). This confirmed efficient biosynthesis nanoparticles. Under greenhouse...
Cryptococcus neoformans is pathogenic yeast, responsible for highly lethal infections in compromised patients around the globe. C. typically initiates mammalian lung tissue and subsequently disseminates to central nervous system where it causes significant pathologies. Virulence genes of are being characterized at an increasing rate, however, we far from a comprehensive understanding their roles genetic interactions. Some these reported virulence scattered throughout different databases,...
Mushrooms are deemed as a special delicacy in many countries. They considered an important cuisine due to their bioactive ingredients and possible health benefits.Herein, we measured selected biological properties of methanol extracts Pleurotus citrinopileatus Boletus edulis fruiting bodies including; vitro antimicrobial activity, anti-α- glucosidase antioxidant anti-lipase activity cytotoxic against different cancer cells normal cells.B. showed high anti-α-glucosidase activity. In contrast,...
Gastric diseases are increasing with the infection of Campylobacter jejuni. Late stages lead to peptic ulcer and gastric carcinoma. C. jejuni infects people within different their life, especially childhood, causing severe diarrhea; it around two-thirds world population. Due bacterial resistance against standard antibiotic, a new strategy is needed impede infections. Plants provide highly varied structures antimicrobial use which unlikely be synthesized in laboratories. A special feature...