A5010671691- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Youth Development and Social Support
- Cancer Treatment and Pharmacology
- Metal complexes synthesis and properties
- Mentoring and Academic Development
- Adolescent and Pediatric Healthcare
- Peroxisome Proliferator-Activated Receptors
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Synthetic Organic Chemistry
- Synthesis and Catalytic Reactions
- Resilience and Mental Health
- Bone and Dental Protein Studies
- PARP inhibition in cancer therapy
- Calcium signaling and nucleotide metabolism
- Social Media and Politics
- Metabolomics and Mass Spectrometry Studies
- Phagocytosis and Immune Regulation
- Nuclear Structure and Function
- Labor Movements and Unions
- Coordination Chemistry and Organometallics
- Hedgehog Signaling Pathway Studies
- Service-Learning and Community Engagement
- Metabolism and Genetic Disorders
- Racial and Ethnic Identity Research
University of South Carolina
2021-2024
Kean University
2024
University of Minnesota
2024
University of Denver
2024
Arizona State University
2024
Dakota State University
2022
North Dakota State University
2022
University of Oregon
2022
USA Mitchell Cancer Institute
2020
University of South Alabama
2020
Abstract Changes in nicotinamide adenine dinucleotide (NAD + ) levels that compromise mitochondrial function trigger release of DNA damaging reactive oxygen species. NAD also affect repair capacity as is a substrate for PARP-enzymes (mono/poly-ADP-ribosylation) and sirtuins (deacetylation). The ecto-5′-nucleotidase CD73, an ectoenzyme highly expressed cancer, suggested to regulate intracellular by processing its bio-precursor, mononucleotide (NMN), from tumor microenvironments, thereby...
Abstract Tumor cells require increased rates of cell metabolism to generate the macromolecules necessary sustain proliferation. They rely heavily on NAD+ as a cofactor for multiple metabolic enzymes in anabolic and catabolic reactions. also serves substrate PARPs, sirtuins, cyclic ADP-ribose synthases. Dysregulation synthase CD38, main NAD'ase cells, is reported cancer types. This study demonstrates novel connection between modulation NAD+, tumor prostate cancer. CD38 expression inversely...
Invadopodia are membrane protrusions that facilitate matrix degradation and cellular invasion. Although lipids have been implicated in several aspects of invadopodia formation, the contributions de novo fatty acid synthesis lipogenesis not defined. Inhibition acetyl-CoA carboxylase 1 (ACC1), committed step synthesis, reduced formation Src-transformed 3T3 (3T3-Src) cells, also decreased ability to degrade gelatin. through AMP-activated kinase (AMPK) activation ACC phosphorylation incidence....
Abstract Tks5 is a Src substrate and adaptor protein previously recognized for its regulation of cancer cell invasion through modulation specialized adhesion structures called podosomes/invadopodia. Here we show the first time that localizes to podosomes primary macrophages, levels increase concurrently with podosome deposition during differentiation monocytes into macrophages. Similar results are reported model THP‐1 cells, which differentiate macrophages form proteolytically active in...
Taxane-based therapy provides a survival benefit in patients with metastatic prostate cancer, yet the median is less than 20 months this setting due part to taxane-associated resistance. Innovative strategies are required overcome chemoresistance for improved patient survival. Here, NanoOrl, new experimental nanoparticle formulation of FDA-approved drug, orlistat, was investigated its cytotoxicity taxane-resistant cancer utilizing two established (TxR) cell lines. Orlistat weight loss drug...
Fatty acid synthase (FASN), the enzyme that catalyzes de novo synthesis of fatty acids, is expressed in many cancer types. Its potential as a therapeutic target well recognized, but inhibitors FASN have not yet been approved for therapy. Orlistat (ORL), an FDA-approved lipase inhibitor, also effective inhibitor FASN. However, ORL extremely hydrophobic and has low systemic uptake after oral administration. Thus, new strategies are required to formulate treatment inhibitor. Here, we report...
The tropism of ovarian cancer (OvCa) to the peritoneal cavity is implicated in widespread dissemination, suboptimal surgery, and poor prognosis. This influenced by stromal factors that are not only critical for oncogenic metastatic cascades, but also modulation cell metabolic plasticity fulfill their high energy demands. In this respect, we investigated role Secreted Protein Acidic Rich Cysteine (SPARC) OvCa. We used a syngeneic model OvCa Sparc-deficient proficient mice gain comprehensive...
Abstract This study examined the role of demographics, civic beliefs, and impact COVID‐19 pandemic in association with distinct forms participation. College students were recruited across 10 institutions higher education to complete an online survey. Bivariate, multivariable linear, logistic regressions performed. Findings indicated that participants from traditionally marginalized backgrounds more likely engage systemchallenging participation community engagement than those privileged...
The preference for and exercise of autonomous decision-making in adolescence is a normative developmental process. Yet, increased autonomy associated with both risks benefits. Connection to others through positive relationships, including mentoring one context that predicts healthy decision-making. In other ways, such relationships can interfere or stifle the development autonomy. synthesizing existing scientific literature on autonomy-supportive practices, we propose framework considering...
In the United States, schools provide a large portion of child and adolescent mental health services; however, systems are restricted by resource workforce shortages while need for services steadily increases. This discrepancy leads to unmanageable caseloads providers reduced access quality youth, highlights expand school-based meet student needs. Herein, we propose novel service-delivery framework offset these challenges integrating mentors within context multitiered support (MTSS) through...
Glioblastoma multiforme (GBM) is one of the deadliest human cancers with very lim-ited treatment options available. The malignant behavior GBM manifest in a tu-mor which highly invasive, resistant to standard cytotoxic chemotherapy and strongly immunosuppressive. Immune checkpoint inhibitors have recently been in-troduced clinic yielded promising results certain cancers. however largely refractory these treatments. immune CD47 has gained attention as potential target for intervention it...
Synthetic transcription factors (STFs) promise to offer a powerful new therapeutic against Cancer, AIDS, and genetic disease. Currently, 10% of drugs are this type, including salicylate tamoxifen. STFs that can appropriately target (and release) their factor binding sites on native genomic DNA provide means directly influence cellular mRNA production. An effective mechanism for screening amongst (TF) candidates would itself be highly valued, such may possible with nanopore cheminformatics...
Objective: The present study examines sociopolitical stress, coping, and well-being among college students. Participants: Young adult students (N = 588; ages 18–29; 72% cisgender women) from 10 universities in the USA participated this study. Methods: Participants completed a 45-minute online survey with closed-ended open-ended questions, administered via Qualtrics. Results: Election-related stress was high notable differences across students' demographic backgrounds (e.g., Hispanic/Latinx...
Background The research-practice gap has not been explored within civics education, and in particular the role of evidence-based curriculum times political trauma. Such research is critical equipping educators with resources to help mitigate trauma experienced by students. Here, we explore types teachers access as well Brokers, Intermediaries Boundary Spanners (BIBS) connecting such sources after historic 6 January 2021 US Capitol insurrection. Aims objectives This study poses following...
Adolescent youth occupy a critical and complex position in refugee families who resettle third country.
This study fills a methodological gap in racial justice research by assessing the utility and validity of Black Community Activism Orientation Scale (BCAOS) racially ethnically diverse sample college-going young adults (N = 624, M 19.4 years, SD 1.89) from 10 colleges United States. Confirmatory factor analysis was conducted to estimate goodness fit proposed three-factor model assess BCAOS. Findings confirmatory provide statistical support for use BCAOS as measure activism communities among...
Abstract The majority of cancers undergo metabolic alterations during initiation and progression disease. Increased de novo lipogenesis is recognized as mark cancer cells. enzymes responsible for fatty acid synthesis are often overexpressed in cancer, indicating that these potential promising targets novel therapies. Acetyl CoA Carboxylase 1 (ACC1) a cytosolic enzyme which catalyzes the rate limiting step through ATP biotin-dependent carboxylation acetyl-CoA to malonyl-CoA. In doing so, it...
In the October 2016 issue of Nature Medicine , Svensson et al. demonstrate that acetyl-CoA carboxylase 1 (ACC1) is required for non-small cell lung cancer (NSCLC) growth in preclinical models and treatment with an allosteric ACC1 inhibitor, ND-646, suppresses NSCLC through fatty acid synthesis inhibition (1). This study provides answers to questions metabolism field has asked since discovery enzymes within pathway are overexpressed (2). Is de novo tumors develop progress? And can be...
Abstract The selective α‐reduction of N‐protected acyl aziridines is achieved with methyldiphenylsilyllithium in THF to produce Mannich bases.
Abstract The alteration of cellular metabolic processes is a common event in the initiation and progression several cancer types. One hallmark cells an increase de novo lipogenesis. enzymes responsible for fatty acid synthesis are overexpressed cancer, suggesting that these may be appropriate targets efforts to inhibit or treat disease. Specifically, Acetyl CoA Carboxylase 1 (ACC1), cytosolic enzyme catalyzes rate limiting step through ATP biotin-dependent carboxylation acetyl-CoA...