A5054967497- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Fungal Infections and Studies
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- Circular RNAs in diseases
- Urticaria and Related Conditions
- Animal Virus Infections Studies
- Asthma and respiratory diseases
- Rheumatoid Arthritis Research and Therapies
- Endoplasmic Reticulum Stress and Disease
- Wound Healing and Treatments
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Autoimmune Bullous Skin Diseases
- RNA Interference and Gene Delivery
University of Szeged
2011-2024
Hungarian Research Network
2021-2022
MTA-SZTE Research Group on Artificial Intelligence
2017-2022
PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the histological distribution of PRINS using in situ hybridization demonstrated variable expressions different human tissues consistent staining pattern epidermal keratinocytes vitro cultured keratinocytes. To identify function(s) we searched for direct interacting partner(s) this stress-induced molecule. In HaCaT NHEK cell lysates,...
Cytosolic DNA fragments are recognized as pathogen- and danger-associated molecular patterns that induce a cascade of innate immune responses. Moreover, excessive cytosolic can enhance chronic inflammation, predominantly by activating inflammasomes, thereby contributing to the pathogenesis diseases, such psoriasis. Psoriasis associated non-protein coding RNA induced stress (PRINS) is long non-coding RNA, which has been shown be with psoriasis susceptibility cellular responses; however,...
We found that Sweet potato feathery mottle virus (SPFMV) P1, a close homologue of mild did not have any silencing suppressor activity. Remodeling the Argonaute (AGO) binding domain SPFMV P1 by introduction two additional WG/GW motifs converted it to with AGO capacity. To our knowledge, this is first instance transformation viral protein unknown function functional suppressor.
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by bradykinesia, resting tremor, and muscle rigidity. To date, approximately 50 genes have been implicated in PD pathogenesis, including both Mendelian with rare mutations low-penetrance polymorphisms. Previous studies of focused on protein-coding genes, less attention was given to long noncoding RNAs (lncRNAs). In this study, we aimed investigate the susceptibility roles lncRNA gene polymorphisms development PD....
Keratinocytes are non-professional immune cells contributing actively to innate responses partially by reacting a wide range of molecular patterns activating pattern recognition receptors. Cytosolic nucleotide fragments as pathogen- or self-derived trigger factors inflammasomes and inducing anti-viral signal transduction pathways well expression inflammatory cytokines. We aimed compare the induced reactions in three keratinocyte cell types—normal human epidermal keratinocytes, HaCaT line...
Psoriasis is a multifactorial, chronic inflammatory skin disease, the development of which affected by both genetic and environmental factors. Cytosolic nucleic acid fragments, recognized as pathogen- danger-associated molecular patterns, are highly abundant in psoriatic skin. It known that exhibits increased levels IL-23 compared to healthy However, relationship between free expression has not been clarified yet. To examine mechanism acids potentially modulate levels, an vitro system was...
Abstract Background Pityriasis rubra pilaris ( PRP ) is a rare chronic inflammatory dermatosis with multifactorial aetiology. It known that particular caspase recruitment domain family member 14 CARD gene mutations are associated familial and certain forms of psoriasis. Additionally, few data available about the role variants in sporadic . The clinical picture variable for different types , therefore choosing adequate treatment often difficult, furthermore there no specific guidelines...
Pityriasis rubra pilaris (PRP) is a rare papulosquamous skin disorder, which phenotypically related to psoriasis. Some familial PRP cases show autosomal dominant inheritance due CARD14 mutations leading increased nuclear factor κB (NFκB) activation. Moreover, polymorphisms have also been implicated in sporadic PRP. A Hungarian patient with childhood onset disease showing worsening of the symptoms adulthood poor therapeutic response underwent genetic screening for gene, revealing four...
Inverse psoriasis is considered to be a rare variant of plaque-type and associated with significantly impaired quality life. Clinical manifestations treatment options are somewhat different for each subtype. Identifying genetic variants that contribute the susceptibility types might improve understanding etiology disease. Since we have no current knowledge about background inverse psoriasis, whole exome sequencing was used comprehensively assess variations in five patients exclusively...
Keratinocytes are one of the primary cells affected by psoriasis inflammation. Our study aimed to delve deeper into their morphology, transcriptome, and epigenome changes in response psoriasis-like We created a novel cytokine mixture mimic mild severe inflammatory conditions cultured keratinocytes. Upon induction inflammation, we observed that keratinocytes exhibited mesenchymal-like phenotype, further confirmed increased VIM mRNA expression results obtained from confocal microscopy....
Even today, the treatment of wounds, especially chronic is still a major burden on healthcare. In addition to many pharmaceutical and surgical interventions, use skin substitutes gains ground in this field. Skin can be considered as artificial tissues, they help regenerate model main functions skin, but have disadvantage being mechanically fragile not durable. They do contain all cellular elements often only specific extracellular matrix proteins. New innovative applications aim at creating...
<h3>Background</h3> Huntington disease (HD) is an uncurable autosomal dominant progressive neurodegenerative disorder. The role of the dopaminergic system in development HD symptoms crucial, as central pathways are overactivated HD. overactivity can be reduced by several drugs. However, their effectivity on psychiatric limited. Moreover, treatment apathy and cognitive still remains challenging Cariprazine, a third-generation antipsychotic acting dopamine D3 D2 receptor agonist. Previous...