A5046627329- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Telomeres, Telomerase, and Senescence
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Corneal surgery and disorders
- Psoriasis: Treatment and Pathogenesis
- Cytomegalovirus and herpesvirus research
- Medical and Biological Sciences
- Genomics and Chromatin Dynamics
- Pancreatic and Hepatic Oncology Research
- Herpesvirus Infections and Treatments
- Extracellular vesicles in disease
- Corneal Surgery and Treatments
- DNA Repair Mechanisms
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Advancements in Transdermal Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Skin and Cellular Biology Research
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Dental Implant Techniques and Outcomes
University of Szeged
2023-2025
Drug resistance is a significant challenge in pancreatic ductal adenocarcinoma (PDAC), where stromal elements such as adipose-derived mesenchymal stem cells (ASCs) contribute to chemoresistant tumor microenvironment (TME). This study explored the effects of oxaliplatin (OXP) and 5-fluorouracil (5-FU) on PDAC (Capan-1) ASCs investigate mechanisms chemoresistance. While OXP 5-FU reduced Capan-1 viability dose- time-dependent manner, demonstrated high resistance, maintaining > 90% even at...
Adipose-derived mesenchymal stem cells are increasingly being used in regenerative medicine as cell therapy targets, including the treatment of burns and ulcers. The potential AD-MSCs some their immunological properties known from vitro studies; however, clinical applications, non-ideal conditions can behave differently inflammatory environments, affecting efficacy outcome therapy. Our aim was to investigate map pathways that microenvironment induce these cells. High-throughput gene...
Blindness resulting from corneal damage affects millions of people worldwide. The scarcity donors adds a layer complexity to patient treatment. Consequently, exploring artificial cornea substitutes has become imperative in the realm clinical research. Scientific advancements have ushered plethora innovative solutions, including keratoprostheses or decellularized scaffolds. development three-dimensional (3D) printing further expanded horizons research this field, delving into feasibility...
Introduction: Adipose tissue-derived mesenchymal stem cells are promising contributors to regenerative medicine, exhibiting the ability regenerate tissues and modulate immune system, which is particularly beneficial for addressing chronic inflammatory ulcers wounds. Despite their inherent capabilities, research suggests that pretreatment amplifies therapeutic effectiveness. Methods: Our experimental design exposed adipose-derived six factors 24 h. We subsequently evaluated gene expression...
The shortages in human tissue and organ donors have made clinical therapy relatively challenging. Therefore, research has been initiated over the last decades to develop artificial tissues organs, particularly from cell cultures. Three-dimensional (3D) bioprinting is a recent technology capable of building structures for implantation, these constructs closely resemble native tissues, such as skin, liver, connective supportive (bone cartilage). In this review, we briefly introduce structure,...
The proper functioning of mesenchymal stem cells (MSCs) is paramount importance for the homeostasis body. Inflammation and infection can alter function MSCs, which also affect regenerative potential immunological status tissues. It not known whether human herpes simplex viruses 1 2 (HSV1 HSV2), well-known pathogens that cause lifelong infections, induce changes in MSCs. In non-healing ulcers, HSV to deeper tissue layers. addition, recur after initially successful cell therapies. Our aim was...
Cells have evolved various DNA repair mechanisms to prevent damage from building up. Malfunctions during can influence cellular homeostasis because they bring on genomic instability through the improper recognition of or dysregulation process. Maintaining proper is also essential for stem cells (SCs), as provide a differentiated cell population living organism. SCs are regularly used in personalized therapy. Patients must be treated with specific activators produce these effectively. This...
Even today, the treatment of wounds, especially chronic is still a major burden on healthcare. In addition to many pharmaceutical and surgical interventions, use skin substitutes gains ground in this field. Skin can be considered as artificial tissues, they help regenerate model main functions skin, but have disadvantage being mechanically fragile not durable. They do contain all cellular elements often only specific extracellular matrix proteins. New innovative applications aim at creating...