A5100391723- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Organ and Tissue Transplantation Research
- Urinary and Genital Oncology Studies
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Autoimmune Bullous Skin Diseases
- Lung Cancer Research Studies
- Cancer-related gene regulation
- 3D Printing in Biomedical Research
- Cancer survivorship and care
- Pelvic and Acetabular Injuries
- Pediatric Urology and Nephrology Studies
- Music Therapy and Health
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Prostate Cancer Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Transplantation: Methods and Outcomes
- Xenotransplantation and immune response
- Mast cells and histamine
- Cancer Cells and Metastasis
- Enhanced Recovery After Surgery
Shenzhen Bao'an District People's Hospital
2024
General Hospital of Guangzhou Military Command
2007-2023
Central South University
2018-2022
Hunan Cancer Hospital
2022
Southern Command Hospital
2020-2022
First Hospital of Qinhuangdao
2021
Third Xiangya Hospital
2018
University of California, Los Angeles
2015
Shanxi Medical University
2014
Nanjing Drum Tower Hospital
2014
Purpose There is a need to supplement or supplant the conventional diagnostic tools, namely, cystoscopy and B-type ultrasound, for bladder cancer (BC). We aimed identify novel DNA methylation markers BC through genome-wide profiling of cell lines subsequent methylation-specific PCR (MSP) screening clinical urine samples. Experimental Design The methyl-DNA binding domain (MBD) capture technique, methylCap/seq, was performed screen specific hypermethylated CpG islands in two (5637 T24). top...
This is an original research of penis allotransplantation. The paper presents experiment allogenic transplantation model in Beagles, with a focus on recovery blood supply and changes tissue architecture. Twenty adult Beagles were allocated to 10 pairs for penile transplantation. After operation, the skin glans observed. If adverse symptoms occurred, transplanted was resected pathologically examined. Frequency urination, urinary stream, patency level recorded 7 days after Cystourethrography...
In our previous study, we attempted to develop a tool for the early diagnosis of non-small cell lung cancer (NSCLC) using DNA methylation biomarkers. With aim improving diagnostic potential by optimizing composition target set, in this 13 candidate genes (ACTA1, AIDH1A2, CBX8, CDH8, EVX1, MGC16275, NEUROG1, NEUROG2, NID2, OTX2OS1, PGAM2, PHOX2B and TOX) were analyzed methylation-specific PCR determine status each gene 5 NSCLC lines tissue samples from 15 healthy volunteers, 103 stage I...
Accurately differentiation of MIBC from non-muscle-invasive bladder cancer (NMIBC) is essential for selecting the optimal treatment plan and obtaining a better prognosis BCa patients. In this study, role CTRW model, VI-RADS their combination in characterizing was evaluated. The parameters combined with could provide significantly diagnostic performance determination than score alone. model serve as compliment to added value predicting muscle invasion cancer.
Colorectal cancer significantly impacts patient quality of life and burdens healthcare systems globally. Fast-track surgery (FTS) aims to alleviate some these by expediting recovery reduce the physiological stress associated with traditional surgical approaches. Despite clinical efficiency FTS, there exists a gap in literature concerning patients' subjective experiences during perioperative period. This study seeks fill that qualitatively exploring patients undergoing FTS for colorectal...
Background: The limitations of primary transurethral resection bladder tumor (TURBt) have led the residual tumors rates as high 75%. intraoperative fluorescence imaging offers a great potential for improving TURBt been confirmed. So we aim to distinguish and normal mucosa using molecular formed by conjugated molecule CSNRDARRC cancer homing peptide with fluorescent dye. was abbreviated FIuo-ACP. In our study, will research image features FIuo-ACP probe targeted diagnosis in vivo ex vivo....
The aim of this study was to observe the physiologic and pathologic changes severed fingers (limbs) under different storage conditions through animal experiments, screen out best preservation conditions.Sixty healthy adult male Sprague-Dawley rats were selected evenly divided into 4 groups, including conventional low-temperature dry (CLTD), University Wisconsin (UW) solution, cryopreservation, cryopreservation + UW solution group. After harvesting limbs, preservated for 72 hours 7 days,...
Abstract Background: To predict and compare machine-learning models with logistic regression (LR) for transfusion requirement among complex renal stones patients receiving PCNL. Methods: The data of 513 PCNL between January 2015 December 2021 from 2 centers were analyzed retrospectively reviewed the pre-, intra-, post-operation factors. We used 80% training set 20% test predictions by LR algorithms, random forest (RF), support vector machine (SVM), extreme gradient boosting trees (XGBoost),...
Abstract Background: The purpose of this study is to analyze the impact post-operative radiotherapy on results in patients with intracranial hemangiopericytoma (HPC). Materials and methods: We retrospectively reviewed 66 HPC treated between 1999 2019 including 29 surgery followed by (11 intensity-modulated (IMRT) 18 stereotactic radiosurgery (SRS)) 37 alone. Chi-squared test was used compare clinical characteristic groups. Kaplan-Meier method overall survival (OS) recurrence-free (RFS)....
Abstract Objective To report the experience of partial inferior pubicectomy in treatment complex posterior urethral stricture after trauma. Methods A total 46 patients with post-traumatic admitted to Department Urology our Hospital from January 2013 September 2021 were selected as research objects and underwent urethroplasty (including nine who had failed previous perineal repair surgery adopted approach). Retrograde urethrograph (RUG) urine flow measurement performed at 1, 3, 12 18 months...
Objective To analyze the clinicopathologic features of primary cutaneous CD30 positive lymphoproliferative disorders. Methods A clinical, pathological and immunohistochemical analysis was carried out in 4 cases lymphomatoid papulosis 5 anaplastic large cell lymphoma. Results Lymphomatoid divided into 3 subtypes, A, B C. The subtype pathologically characterized by pleomorphic cells or Steinberg-reed scattered patchly distributed among many inflammatory cells; showed changes characteristic...
Objective To establish models of targeted therapy for glioblastoma stem cell xenografs growth in mice by using micro-osmotic Pumps to provide experimental foundations the inhibitors treating vivo. Methods Human cells 2×104 cells/μL were inoculated into 10 inbred strain female SCID stereotactic technique (right subependymal zone); pumps which could be infused aimed regions immediately installed mice. Evaluation whether tolerate this surgery was performed after operation. Survival data...
Objective To evaluate the efficacy and safety of transurethral thulium-Yag laser(Tm-Yag Laser) resection bladder tumor in treatment non-muscle invasive cancer(NMIBC). Methods The clinical data 186 patients who underwent with pathologically identified NMIBC were retrospectively analyzed.76 cases 110 cancer Tm-Yag Laser group TURBT group, respectively. The operative time, intraoperative blood loss, incidence obturator nerve reflex, days for urethral catheterization, duration...
Introduction Regulatory macrophages (Mreg) have been experiencing a clinical trial in the One Study to test their potential immunomodulation allotransplantation. However limited number of Mreg induced from individual adult peripheral blood mononuclear cells (PBMC) may restrict application. Thus, exploring an alternative source for is required development as practicable cell therapy. In this study cord (CB) derived used cellular immunotherapy allotransplantation was investigated. Materials...
Abstract Background Octamer-binding transcription factor 4 pseudogene 5 (OCT4-pg5) contributes to tumor progression in many cancer types, but contributions bladder (BC) have not been investigated. Methods Real-time quantity PCR ( RT-qPCR) was performed measure OCT4-pg5 and OCT4B expressions different cell lines grades of cancer. The effects OCT4-pg5, miR-145 on proliferation metastasis were determined by vitro vivo experiments. Luciferase reporter assay carried out reveal the interaction...