A5002157481- Peripheral Artery Disease Management
- Rheumatoid Arthritis Research and Therapies
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Vascular Procedures and Complications
- Angiogenesis and VEGF in Cancer
- Lung Cancer Research Studies
- Molecular Biology Techniques and Applications
- Central Venous Catheters and Hemodialysis
- Cardiovascular Health and Disease Prevention
- Diagnosis and Treatment of Venous Diseases
- Genetic factors in colorectal cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Hernia repair and management
- Vascular anomalies and interventions
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Immunology Research
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Aortic Disease and Treatment Approaches
Norfolk and Norwich University Hospital
2017-2024
Norfolk and Norwich University Hospitals NHS Foundation Trust
2019-2024
Sarah Cannon Research Institute
2016-2024
Informa Healthcare
2021-2022
Gentofte Hospital
2019-2021
Copenhagen University Hospital
2018
Slagelse Hospital
2018
Rigshospitalet
2018
Genomics (United Kingdom)
2018
University College London
2016
<h3>Objectives</h3> To investigate the incidence of cancer in arthritis patients treated with or without TNFα inhibitors (TNF-I). <h3>Methods</h3> Arthritis from DANBIO database were followed-up for Danish Cancer Registry during 2000–2008. <h3>Results</h3> Hazard ratio overall was 1.02 (95% confidence interval (CI) 0.80-1.30) 3347 TNF-I-treated RA compared to non-treated. Excess among found colon (HR 3.52 (95%CI 1.11-11.15), whereas 6 and 0 ovarian cases observed non-treated patients,...
<h3>Importance</h3> Whether using magnetic resonance imaging (MRI) to guide treatment in patients with rheumatoid arthritis (RA) improves disease activity and slows joint damage progression is unknown. <h3>Objective</h3> To determine whether an MRI-guided treat-to-target strategy vs a conventional clinical outcomes RA remission. <h3>Design, Setting, Participants</h3> Two-year, randomized, multicenter trial conducted at 9 hospitals Denmark. Two hundred remission (disease score 28...
Kirsten rat sarcoma viral oncogene ( KRAS ) is a frequently mutated in lung cancer, now amenable to targeted therapy with allele-specific G12C inhibitors. Non-small cell cancer (NSCLC) driver mutations show geographical variability and therefore the mutation breakdown, co-occurring oncogenic rate associated PD-L1 expression were studied large UK cohort. We interrogated archival clinical next-generation sequencing (NGS) data over 5 years. 3283 NSCLC samples included, referred from 38 centres...
Peripheral arterial disease (PAD) is an important global healthcare problem associated with considerable morbidity and mortality. This manifestation of atherosclerosis the pathophysiological processes involved in its development, progression complications are atherothrombosis thromboembolism. Over 150 years ago, Virchow described a triad abnormalities (abnormal blood flow, abnormal vessel wall constituents) thrombus formation (thrombogenesis). An improvement biochemical techniques has...
Background Multigene-based PCR tests are time-consuming and limiting aspects of the protocol include increased risk operator-based variation. In addition, such protocols complex to transfer reproduce between laboratories. Aims Evaluate clinical utility a pre-spotted plate (PSP) for novel multigene (n = 51) blood-based gene expression diagnostic assay neuroendocrine tumors (NETs). Methods A pilot study 44; 8 controls 36 NETs) was undertaken compare CQ, normalized algorithm-based output...
Objective: To compare the mean and maximum common carotid intima–media thickness (CCIMT) in Blacks (Black Caribbean Black African) South Asians (People originating from India, Pakistan Bangladesh) a population survey make associations with established cardiovascular risk factors peripheral arterial disease (PAD). Patients methods: A subset of 492 (293 199 Blacks) out 572 participants aged ≥45 years recruited sub-study to Ethnic-Echocardiographic Heart England Screening (E-ECHOES)...
Targeted next-generation sequencing (tNGS) is increasingly being adopted as an alternative to single gene testing in some centres. Our aim was assess the overall fitness and utility of tNGS a routine clinical test non-small cell lung cancer (NSCLC).All NSCLC cases submitted laboratory for analysis over 3-year period were included. Rejection/failure rates turnaround times calculated. For reportable cases, data relating observed genetic changes likely be driving tumour growth and/or...
Objective: To determine whether differences exist in prevalence of peripheral arterial disease (PAD) between South Asians (people originating from India, Pakistan and Bangladesh) Blacks (Black Caribbean Black African), the two largest minority ethnic groups UK. if associations with cardiovascular risk factors this differ these groups. Patients Methods: We recruited 572 patients (356 Asian 216 Blacks) ≥45 years as a sub-study to community screening project, Ethnic-Echocardiographic Heart...
Targeted therapies for non-small cell lung carcinoma (NSCLC) rely on the detection of specific genomic lesions, such as mutations within epidermal growth factor receptor (EGFR) gene. The Biocartis Idylla platform and single-use EGFR mutation test cartridge is CE-IVD use with formalin-fixed paraffin embedded (FFPE) tumour material, but can also function off-scope using extracted DNA input material. This expand utility potentially conserve valuable tissue.We sought to evaluate performance this...
Abstract Background The aim was to review a consecutive series of patients treated with laparoscopic abdominal aortic aneurysm (AAA) repair. These were compared having elective open AAA Methods Demographic and operative details collected prospectively outcomes recorded for all undergoing or Results A total 316 underwent (51), (53) endovascular (EVAR; 212) repair between 2007 2013. median age who had 72 (i.q.r. 66–75) years, 92·3 per cent men. There no significant difference in sex...
Abstract Background We determined the diagnostic accuracy of Edinburgh Claudication Questionnaire (ECQ) in 1 st generation Black African-Caribbean UK migrants as previous questionnaires have been found to be less accurate this population. also translated versions ECQ South Asian migrants, has not investigated before. Methods Subjects were recruited from Ethnic-Echocardiographic Heart England Screening (E-ECHOES) study, a community based screening survey for heart failure minority ethnic...
Abstract Objectives To study if clinical, radiographic and MRI markers can predict damage progression achievement of stringent remission in patients with established RA clinical followed by a targeted treatment strategy. Methods (DAS28-CRP &lt;3.2, no swollen joints) receiving conventional synthetic DMARDs were randomized to or MRI-targeted treat-to-target strategies predefined algorithmic escalations. Potentially predictive baseline variables tested multivariate logistic regression...
Duplex ultrasound surveillance with pre-emptive treatment of an identified stenosis is increasingly being utilised to help maintain arteriovenous fistula patency. This study aims determine whether post-operative duplex can improve patency at 12 months and the proportion 'pre-haemodialysis' patients commencing haemodialysis via a usable fistula.All fistulae formed between 1st January 2015 31st August 2017 in single, tertiary vascular centre were included. Primary secondary months, along...
The association between gender and length of hospital stay following infra-inguinal bypass (IIB) surgery is unclear. While previous studies have reported disparities in (LoS), the results are conflicting could be attributable to other confounding factors. We undertook this cohort study determine if there any differences for PAD after adjusting well-known confounders.