A5008655221- Neonatal and fetal brain pathology
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Thermal Regulation in Medicine
- Stroke Rehabilitation and Recovery
- Cardiac Arrest and Resuscitation
- Peripheral Artery Disease Management
- Migraine and Headache Studies
- Multiple Sclerosis Research Studies
- Venous Thromboembolism Diagnosis and Management
- Botulinum Toxin and Related Neurological Disorders
- Intracranial Aneurysms: Treatment and Complications
- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Acne and Rosacea Treatments and Effects
- Herpesvirus Infections and Treatments
- Biomarkers in Disease Mechanisms
- Retinopathy of Prematurity Studies
- Spinal Cord Injury Research
- Biochemical and Structural Characterization
- Vascular Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
University of Toronto
2021-2025
Sunnybrook Health Science Centre
2024
Health Sciences Centre
2024
Deleted Institution
2021-2023
University of Calgary
2013-2021
Foothills Medical Centre
2021
St. Michael's Hospital
2021
Alberta Children's Hospital
2016-2017
Alberta Children's Hospital Research Institute
2016
University of Cambridge
1972
Aim Post‐traumatic headaches (PTHs) following mild traumatic brain injury ( mTBI ) are common; however, few studies have examined the characteristics of PTHs or their response to treatment. The aims this study were (1) describe clinical PTH in a prospective cohort children presenting paediatric emergency department with , and (2) evaluate Method was obtained from longitudinal symptoms n =670; 385 males, 285 females) comparison group extracranial =120; 61 59 females). A retrospective chart...
Seven cases are reported of death in old people associated with transcervical fractures the femur and occurring shortly after insertion a Thompson prosthesis. They compared six fatalities following similar injury but not surgically treated three which followed internal fixation. Positive controls for massive fat embolism were selected from fatal multiple severe skeletal due to road accidents.It seems likely that patients undergoing this operation peculiarly susceptible lethal embolism. The...
Background Perinatal stroke is the leading cause of hemiparetic cerebral palsy. Motor deficits and their treatment are commonly emphasized in literature. Sensory dysfunction may be an important contributor to disability, but it difficult measure accurately clinically. Objective Use robotics quantify position sense children with perinatal determine association common clinical measures. Methods Case-control study. Participants were aged 6 19 years magnetic resonance imaging-confirmed...
While sensory dysfunction is common in children with hemiparetic cerebral palsy (CP) secondary to perinatal stroke, it an understudied contributor disability limited objective measurement tools. Robotic technology offers the potential objectively measure complex sensorimotor function but has been stroke. The present study aimed quantify kinesthetic deficits stroke and determine their association clinical function. Case–control study. Participants were 6–19 years of age. Stroke participants...
Introduction: Because of the risk infarcted tissue leading to symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolysis for acute ischemic stroke, patients are monitored at least 24 hours in a critical care setting. We aim assess incidence and factors sICH following stroke. hypothesize that is higher with older age, longer symptom onset-to-needle (OTN), greater stroke severity, lower baseline ASPECTS score. Methods: Adults ≥18 years were randomized into AcT trial receive...
Abstract Perinatal stroke causes most hemiparetic cerebral palsy, resulting in lifelong disability. We have demonstrated the ability of robots to quantify sensory dysfunction children but relationship between such deficits and tract structural connectivity has not been explored. It was aimed characterize dorsal column medial lemniscus (DCML) pathway proprioceptive with perinatal stroke. Twenty‐nine participants (6–19 years old) MRI‐classified, unilateral ischemic (14 arterial, 15 venous),...
Abstract Perinatal stroke is the leading cause of hemiparetic cerebral palsy (CP), resulting in life‐long disability. In this study, we examined relationship between robotic upper extremity motor impairment and corticospinal tract (CST) diffusion properties. Thirty‐three children with unilateral perinatal ischemic (17 arterial, 16 venous) hemiparesis were recruited from a population‐based research cohort. Bilateral CSTs defined using tensor imaging (DTI) four metrics quantified: fractional...
Detailed kinematics of motor impairment the contralesional ("affected") and ipsilesional ("unaffected") limbs in children with hemiparetic cerebral palsy are not well understood. We aimed to 1) quantify reaching both arms perinatal stroke using a robotic exoskeleton, 2) assess correlation kinematic parameters clinical assessments. This prospective, case-control study involved Alberta Perinatal Stroke Project, population-based research cohort, Foothills Medical Center Robotics Laboratory...
Perinatal stroke is the most common cause of unilateral cerebral palsy. Mechanisms post-stroke developmental plasticity in children are poorly understood. To better understand relationship between functional connectivity and disability, we used resting-state fMRI to compare sensorimotor with clinical dysfunction. School-aged periventricular venous infarction (PVI) palsy were compared controls. Resting-state BOLD signal was acquired on 3 T MRI analyzed using CONN SPM12. Functional computed...
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Abstract Background While motor deficits are the hallmark of hemiparetic cerebral palsy, children may also experience impairments in visuospatial attention that interfere with participation complex activities, including sports or driving. In this study, we used a robotic object hitting task to assess bilateral sensorimotor control and skills hemiparesis due perinatal arterial ischemic stroke (AIS) periventricular venous infarct (PVI). We hypothesized performance would be impaired bilaterally...
Background and purpose Collateral assessment using CT angiography is a promising modality for selecting patients endovascular thrombectomy (EVT) in the late window (6–24 hours). The outcome of these compared with those selected perfusion imaging not clear. Methods We pooled data from seven trials registries EVT-treated late-time window. Patients were classified according to baseline into collateral alone (collateral cohort) plus (perfusion cohort). primary was proportion achieving...
Antimicrobial peptides (AMPs) constitute promising candidates for the development of new antibiotics. Among ever-expanding family AMPs, tritrpticin has strong antimicrobial activity against a broad range pathogens. This 13-residue peptide an unusual amino acid sequence that is almost symmetrical and features three central Trp residues with two Arg near each end peptide. In this work, role sequential in was studied systematic fashion by making series synthetic single-, double- triple-Trp...
Stroke is a leading cause of perinatal brain injury with variable outcomes including cerebral palsy and epilepsy. The biological processes that underlie these heterogeneous are poorly understood. Alterations in developmental myelination recognized as major determinant outcome preterm but have not been explored stroke. We aimed to characterize hemiparetic children after arterial stroke, hypothesizing ipsilesional would be impaired, the degree which correlate poor outcome. Retrospective,...
Abstract Background Activities of daily living frequently require children to make rapid decisions and execute desired motor actions while inhibiting unwanted actions. Children with hemiparetic cerebral palsy due perinatal stroke may have deficits in executive functioning addition impairments. The objective this study was use a robotic object hit avoid task assess the ability decisions. Methods Forty-five 146 typically developing (both groups ages 6–19 years) completed using Kinarm...
Studies using clinical measures have suggested that proprioceptive dysfunction is related to motor impairment of the upper extremity following adult stroke. We used robotic technology and assess relationship between position sense reaching with hemiparetic limb in children perinatal stroke.Prospective term-born magnetic resonance imaging-confirmed ischemic stroke deficits were recruited from a population-based cohort. Neurotypical controls community. Participants completed two tasks Kinarm...
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ABSTRACT: Serum troponin is often elevated in patients with acute stroke and its mechanism unknown. In a retrospective single-center cohort study, we evaluated the association between severity serum 187 using multivariable modified Poisson models. A one-point increase National Institutes of Health Stroke Scale (measure severity) was associated marginally higher level adjusted models (aIRR 1.03; 1.01–1.05, P = 0.001). The modest, yet potentially independent, troponins could suggest neurogenic...
Multiple sclerosis (MS) is an inflammatory disease that causes chronic neurological disability in young adults. Modulation of sphingosine 1-phosphate (S1P) receptors, a group receptors that, among other things, regulate egression lymphocytes from lymph nodes, has proven to be effective treating relapsing MS. Fingolimod, the first oral S1P receptor modulator, demonstrated potent efficacy and tolerability, but can cause undesirable side effects due its interaction with wide range subtypes....