A5026662076- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Nerve injury and regeneration
- Bacterial Infections and Vaccines
- Infectious Diseases and Tuberculosis
- Antimicrobial Peptides and Activities
- Wound Healing and Treatments
- Mosquito-borne diseases and control
- Biochemical and Structural Characterization
- Amoebic Infections and Treatments
- Aquaculture disease management and microbiota
- Toxin Mechanisms and Immunotoxins
- Neurogenesis and neuroplasticity mechanisms
- Antimicrobial Resistance in Staphylococcus
Rutgers, The State University of New Jersey
2013-2020
Rutgers New Jersey Medical School
2017
New Jersey Institute of Technology
2010
Cyclic di-GMP (c-di-GMP) controls the transition between sessility and motility in many bacterial species. This regulation is achieved by a variety of mechanisms including alteration transcription initiation inhibition flagellar function. How c-di-GMP inhibits Vibrio cholerae has not been determined. FlrA, homologue binding Pseudomonas aeruginosa regulator FleQ, master V. biosynthesis regulon. Here we show that to FlrA abrogates promoter flrBC operon, deactivating expression does regulate...
Significance Second messengers are employed by all organisms to regulate fundamental behaviors, including biofilm formation, motility, metabolism, and pathogenesis in bacteria. We have identified a phospholipase the El Tor Vibrio cholerae biotype, responsible for current cholera pandemic, that is directly activated second messenger 3′, 3′-cyclic GMP-AMP (cGAMP). Discovery of this proteinaceous bacterial cGAMP effector sheds light on functions basic principles signaling. Both synthase encoded...
Many bacteria use quorum sensing (QS) to regulate virulence factor production in response changes population density. QS is mediated through the production, secretion, and detection of signaling molecules called autoinducers (AIs) modulate population-wide behavioral changes. Four histidine kinases, LuxPQ, CqsS, CqsR VpsS, have been identified Vibrio cholerae as receptors activate gene expression at low cell Detection AIs by these leads repression high The redundancy among puzzling since any...
ABSTRACT Mycobacterium tuberculosis (Mtb) secretes pathogenicity factors and immunologically active molecules via membrane vesicles. However, nothing is known about the mechanisms involved in mycobacterial vesicle biogenesis. This study investigates molecular determinants of production Mtb by analyzing cells under conditions high production: iron limitation VirR restriction. Ultrastructural analysis showed extensive cell envelope restructuring association with release that correlated...
ABSTRACT The pathogen that causes cholera, Vibrio cholerae , uses the cell-cell communication process known as quorum sensing (QS) to regulate virulence factor production and biofilm formation in response changes population density complexity. QS is mediated through detection of extracellular chemical signals called autoinducers. Four histidine kinases, LuxPQ, CqsS, CqsR VpsS, have been identified receptors activate key regulator LuxO at low cell density. At high density, autoinducers by...
The purpose of this study is to develop biodegradable nerve guidance conduits seeded with Schwann cells (SC) using chitosan-based biopolymers for improving regeneration. Chitosan, prepared from alkaline hydrolysis chitin, a natural polysaccharide biopolymer, having biocompatibility and biodegradability. In study, chitosan chitosan-gelatin membranes were prepared, characterized, evaluated. SC isolated rat sciatic was on investigate their interactions. To enhance the attachment growth...