A5101528593- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Cancer-related molecular mechanisms research
- High-Energy Particle Collisions Research
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Particle Detector Development and Performance
- Nuclear reactor physics and engineering
- Ferroptosis and cancer prognosis
- Particle physics theoretical and experimental studies
- Biliary and Gastrointestinal Fistulas
- Quantum Chromodynamics and Particle Interactions
- Pelvic floor disorders treatments
- Multiple and Secondary Primary Cancers
- Gastrointestinal motility and disorders
- Gastrointestinal Tumor Research and Treatment
- Appendicitis Diagnosis and Management
- Radiation Detection and Scintillator Technologies
- Amoebic Infections and Treatments
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Cancer Cells and Metastasis
Hunan Normal University
2018-2024
Hunan Provincial People's Hospital
2009-2024
Tsinghua University
2012-2024
Hebei University of Chinese Medicine
2021
Shandong Academy of Chinese Medicine
2021
University of Illinois Chicago
2016
American Physical Society
2016
Indiana University Bloomington
2016
Argonne National Laboratory
2016
Central China Normal University
2016
HOX transcript antisense RNA (HOTAIR) plays a vital role in carcinogenesis. However, its functional and regulatory roles remain unclear. In this study, we aimed to investigate biological function clinical significance human colorectal cancer (CRC).We examined the expression levels of lncRNA HOTAIR miR-203a-3p CRC tissues cell lines by qRT-PCR. Gain loss-of-function assays were performed examine effects on proliferation chemoresistance cells. The possible mechanisms also explored fluorescence...
Background: Liver metastasis of colon cancer is strongly affected by the tumor microenvironment (TME), with interactions between cells and cancer-associated fibroblasts (CAFs) in particular. TGF-β well known for its ability to mediate CAF phenotype, CXCR4 expression closely correlated poor prognosis CRC. The relationship these two signaling pathways remains be delineated liver cancer.Methods: Immunohistochemistry was employed investigate 45 human specimens primary colorectal (CRC)...
Parachromis managuensis is a native cichlid fish from Central America and the most commonly traded species within its genus. This study presents first chromosome-scale genome assembly of P. using PacBio HiFi long reads Hi-C sequencing data. The size approximately 896.66 Mb, with scaffold N50 38.19 Mb. assembled demonstrates high quality in terms completeness accuracy, BUSCO score 98.85% value (QV) 50.95. A total 888.60 Mb (99.10%) sequences were anchored to 24 pseudochromosomes....
BACKGROUND Major depressive disorder (MDD) with comorbid anxiety is an intricate psychiatric condition, but limited research available on the degree centrality (DC) between anxious MDD and nonanxious patients. AIM To examine changes in DC values their use as neuroimaging biomarkers non-anxious METHODS We examined 23 patients, 30 28 healthy controls (HCs) using for data analysis. RESULTS Compared HCs, group reported markedly reduced right fusiform gyrus (FFG) inferior occipital gyrus, whereas...
Abstract Here, an RNA‐sequencing assay revealed long noncoding RNAs (lncRNAs) with ectopic expression between colon cancer (CC) and normal epithelial cells, in which lncRNA B4GALT1‐AS1 exhibited the highest change. A 3‐(4,5‐dimethythiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide indicated that knockdown had no effect on CC cell viability, however, clone formation analysis showed attenuated capacity of formation. Additionally, gene set enrichment this data positive stem cell‐differentiated...
Background: Tumor microenvironment (TME) is a crucial part of tumor hallmarks. Mesenchymal stem cells (MSCs), important components TME, are the main source Carcinoma-associated fibroblasts (CAFs), but mechanism transformation regulation still unclear. Transforming growth factor-β1 (TGF-β1), chemokine Stromal cell-derived factor-1 (SDF-1) and its endogenous receptor CXCR4 may play roles during this process.Methods: Co-culture technique was used to explore effects MSCs on proliferation,...
Aim MicroRNA-93 (miR-93) has been shown to suppress proliferation and colony formation of colon cancer stem cells. The aim this study was examine the expression pattern prognostic value miR-93 in patients with cancer. Materials methods A quantitative real-time PCR analysis carried out detect levels 138 paired samples tumoral nontumoral tissues diagnosed Associations clinicopathological parameters survival were also examined. Results significantly decreased compared (P<0.001). Low correlated...
This study aims to evaluate the beneficial effects of anti-epileptic mechanisms baicalin (BA) on cognitive dysfunction and neurodegeneration in pentylenetetrazol (PTZ)-induced epileptic rats.First, PTZ-induced rats were administered intraperitoneally a sub-convulsive dose PTZ (40 mg/kg) daily, seizure susceptibility (the degree seizures latency) was evaluated using Racine's criterion. Then, classical behavioral experiments performed test whether BA ameliorated dysfunction. Neurodegeneration...
The prognostic factors for patients with T1-2 colorectal cancer (CRC) after radical resection and the predictive value of lymph node distribution (LND) system compared TNM these have not been well studied. From September 2009 June 2016, a total 541 consecutive CRC who accepted in two centers were included this study. Their clinicopathological characteristics prognosis analyzed using univariate multivariate Cox regression analyses. LND system. Univariate analysis revealed that patients'...
Abstract Background D3 lymph node dissection with left colic artery (LCA) preservation in rectal cancer surgery seems to have little effect on reducing postoperative anastomotic leakage. So we first propose LCA and sigmoid (SA) preservation. This novel procedure deserves further study. Methods Rectal patients who underwent laparoscopic or SA between January 2017 2020 were retrospectively assessed. The categorized into two groups: the of group group. A 1:1 propensity score-matched analysis...
Abstract The impact parameter characterizes the centrality in nucleus-nucleus collision geometry. determination of parameters real experiments is usually based on reconstructed particle attributes or derived event-level observables. For scheduled Cooler-storage-ring External-target Experiment (CEE), low beam energy reduces correlation between and charged multiplicity, which decreases validity explicit methods. This work investigates a few neural network-based models that directly take...
Adipose-derived stem cells (ASCs) can differentiate into smooth muscle and have been engineered elastic small diameter blood vessel walls in vitro. However, the mechanisms involved development of three-dimensional (3D) vascular tissue remain poorly understood. The present study analyzed protein expression profiles constructed by human ASCs using methods two-dimensional gel electrophoresis (2DE) mass spectrometry (MS). These results were compared to normal arterial walls. A total 1701±15...
Abstract RE (Radiation enteritis) has been characterized by the inflammation reaction, and in this study, we aim to explore inflammatory cytokines underlying mechanism involved pathogenesis of RE. Luciferase assay was performed whether polymorphism affected expression let‐7, also validated let‐7 directly regulated f IL‐6 expression. Then Elisa study rs13293512 associated with enteritis occurrence. And Western‐blot real‐time PCR were verify relationship between IL‐6. 380 colorectal cancer...
Background: Platinum resistance poses a significant problem for oncology clinicians. As result, the role of epigenetics and DNA methylation in platinum-based chemoresistance has gained increasing attention from researchers recent years. A systematic investigation aberrant patterns related to platinum across various cancer types is urgently needed. Methods: We analyzed chemotherapy response-related different perspectives 618 patients 13 integrated transcriptional clinical data. Spearman’s...
A trigger system has been designed and implemented for the HIRFL-CSR external target experiment (CEE), spectrometer studying nuclear matter properties with heavy ion collisions in GeV energy region. The adopts master-slave structure serial data transmission mode using optical fiber to deal different types of detectors long-distance signal transmission. logic can be accessed based on command register controlled by a remote computer. overall field programmable gate array (FPGA) flexibly...
Introduction: UMP-CMP kinase 2 (CMPK2) is involved in mitochondrial DNA synthesis which can be oxidized and released into the cytoplasm innate immunity. It initiates assembly of NLRP3 inflammasomes mediates various pathological processes such as human immunodeficiency virus infection systemic lupus erythematosus. However role CMPK2 tumor progression immunity remains unclear. background: synthesis, Method: In this study we conducted a systematical analysis across 33 different cancers based on...
The half-size prototype of the multi wire drift chamber (MWDC) for cooling storage ring (CSR) external-target experiment (CEE) was assembled and tested in 350 MeV/u Kr+Fe reactions on heavy ion research facility Lanzhou (HIRFL). consists 6 sense layers, where wires are stretched three directions X, U V, meeting $0^\circ$, $30^\circ$ $-30^\circ$ with respect to vertical axis, respectively. sensitive area is $76 {\rm cm} \times 76 cm}$. amplified shaped signals from anode digitized a serial...