A5102833717- Essential Oils and Antimicrobial Activity
- Nail Diseases and Treatments
- Skin Protection and Aging
- Bacterial biofilms and quorum sensing
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Bee Products Chemical Analysis
- Herpesvirus Infections and Treatments
- Acne and Rosacea Treatments and Effects
- Insect Pest Control Strategies
- Antimicrobial Resistance in Staphylococcus
- Pharmacological Effects of Natural Compounds
- Textile materials and evaluations
- Skin and Cellular Biology Research
- Facial Rejuvenation and Surgery Techniques
- Indoor Air Quality and Microbial Exposure
- Viral Infections and Vectors
- Ocular Oncology and Treatments
- Pressure Ulcer Prevention and Management
- Eosinophilic Disorders and Syndromes
- Microbial Community Ecology and Physiology
- Occupational exposure and asthma
- Allelopathy and phytotoxic interactions
- Phytochemistry Medicinal Plant Applications
- Reconstructive Facial Surgery Techniques
University of Sassari
2016-2025
IRCCS Materno Infantile Burlo Garofolo
2023-2024
Azienda Ospedaliera Universitaria Pisana
2024
University of Trieste
2020-2021
University of Bergamo
1994
In recent years, advances in melanoma treatment have renewed patient hope. This comprehensive review emphasizes the evolving landscape, particularly highlighting first-line strategies and interplay between immune-checkpoint inhibitors (ICIs) targeted therapies. Ipilimumab plus nivolumab has achieved best median overall survival, exceeding 70 months. However, introduction of new ICIs, like relatlimab, added complexity to therapy decisions. Our aim is guide clinicians making personalized...
As a consequence of the worsening situation with multidrug-resistant (MDR) pathogens and disparity in commercialization novel antimicrobial agents, scientists have been prompted to seek out new compounds activity from wide range sources, including medicinal plants. In present study, antibacterial, antifungal, anti-virulence, resistance-modulating properties essential oil Sardinian endemic
The formation of a protective biofilm by Pseudomonas aeruginosa (PA) is one the hallmarks their survival both in vivo and harsh environmental conditions, thus, biofilm-eradication has relevance from therapeutic perspectives for infection control. aim our study was to investigate possible relationship between antibiotic resistance, biofilm-forming capacity virulence factors n = 166 PA isolates origin. Antimicrobial susceptibility testing phenotypic detection resistance determinants were...
Background: Chemotherapy continues to be the cornerstone for management of leishmaniasis. The preferred medications are pricey and have a number unfavorable side effects. These restrictions make it necessary produce novel antileishmanial chemicals, plants opportunities in this respect. Objectives: This study aimed evaluate properties Thymus syriacus essential oil its mechanisms action. Results: Our findings demonstrated that oil, rich thymol, exhibited potent activity, with an IC50 value...
Antibiotics that suppress Propionibacterium acnes are the standard treatment for acne but becoming less effective, due to appearance of antibiotic-resistant strains. Many plants known have innate antimicrobial action and can be used as alternatives antibiotics; thus, it is necessary prove their effectiveness in vivo. This study aimed evaluate anti-acne efficacy a new cream based on three natural extracts, comparing erythromycin placebo.Sixty patients with mild moderate vulgaris were randomly...
The production of biofilms is a critical factor in facilitating the survival Staphylococcus spp. vivo and protecting against various environmental noxa. possible relationship between antibiotic-resistant phenotype biofilm-forming capacity has raised considerable interest. purpose study was to assess interdependence 299 (S. aureus n = 143, non-aureus staphylococci [NAS] 156) origin. Antimicrobial susceptibility testing detection methicillin resistance (MR) performed. isolates produce assessed...
Health care spending in Italy is high and continues to increase; assessing the long-term health economic outcomes of new therapies essential. Atopic dermatitis (AD) a chronic, pruritic, immune-mediated inflammatory dermatosis, clinical condition that significantly affects patients' quality life at cost requires continuous care. This retrospective study aimed assess direct adverse drug reactions (ADRs) Dupilumab outcomes. All AD patients treated with Sassari University Hospital, Italy,...
Several dermal substitutes are available on the market, but there is no precise indication that helps surgeons choose proper one. Few studies have tried to compare different xenogeneic bioengineered products, objective bio-parametric comparison has been made yet. Fifteen patients who underwent skin reconstruction with Integra® or Pelnac® were retrospectively evaluated. After at least 12 months of follow-up, an and quantitative assessment several biophysical properties, such as color,...
Aims In this study, five essential oils (EOs) from different species of Lavandula hybrida abrialis, for R.C., 'super A', Z' and vera its hybrids Lavender were evaluated against 26 dust-isolated fungal strains North Africa.
Background: Research results on the efficacy of sunblock sticks in avoiding or reducing Herpes labialis (HL) recurrences are contradictory and has shown mixed results, with some protection reported under experimental conditions that could not be replicated natural conditions.Objective: The purpose present work was to carry out an vivo test effectiveness a protective lip product preventing recurrent HL during summer.Methods: An exploratory randomized crossover study performed 20 adult...
Werner syndrome (WS) is a rare autosomal recessive disorder characterized by premature aging in adults. Although not sufficient to diagnose WS, persistent short stature and alteration of the dentition are among few early signs that appear at puberty can lead suspected diagnosis.The study aimed quantifying WS skin through biophysical parameters find new be applied together with clinical observations order disease early.The disorders induced were studied using noninvasive techniques: Tewameter...
The use of essential oil (EO) in treating infected wounds is still challenging. A lot effort has been made to make such an application more convenient. Recently, microneedles (MNDs) have considered as a smart dermal delivery system overcome the poor absorption and distribution, low bioavailability, skin penetration some drugs. aim our study evaluate wound healing activity juniper-EO-loaded MNDs (EO MNDs) against with bacterial fungal infection. Polyvinylpyrrolidone (PVP) were prepared using...
Double little toenails, or accessory nails of the fifth toe, are a rare and particular deformity distinct from other nail dysplasias. We describe 4 cases female patients, including 6-year-old girl, experiencing this bilateral condition after birth. The anomaly shows an autosomal-dominant type transmission that affects only individuals. subjects examined were family without marriages between blood relatives neuroectodermal hereditary diseases. patients had no bone alterations terminal...
Background: The goal of this study was to monitor the microbial biodiversity in beach sand that is heavily visited by tourists during summer, and determinate whether high presence bathers (around 5000 per day) can modify composition. Methods: Between 2016 2020, 150 samples were collected from nine different points at La Pelosa Sardinia, Italy. Non-culturing methods used; DNA extraction meta-barcode sequencing performed. All analyzed with for 16S ITS sequences. Results: Fungal genera differ...
Summary Background Adhesive pads should reduce the action of local muscle contraction on skin leading to a decrease in depth existing wrinkles and formation new dynamic wrinkles. Aim work This study aims at assessing antiwrinkles adhesive during time, temporary improvement facial appearance by reducing vision linear improving elasticity. Patients methods Thirty‐nine subjects participated placebo‐controlled study. In short‐term test, measurements were taken 15, 30, 60 minutes following 30...
Erythema annulare centrifugum (EAC) is a rare erythema characterized by erythematous and urticarial papules or annular plaques that enlarges centrifugally. The lesions usually involve the thighs legs. Several disorders are occasionally associated with EAC, infections, including mycoses, bacteria, viruses drugs have also been regarded as possible causes of this eruption. We present 42-year-old dark-skinned woman affected recurrent EAC appeared secondary to influenza type A (H1N1)....
Human coronaviruses are a continuous threat to the human population and have limited antiviral treatments, recent COVID-19 pandemic sparked interest in finding new strategies, such as natural products, combat emerging coronaviruses. Rapid efforts scientific community identify effective agents for remain focus minimize mortalities global setbacks. In this study, an essential oil derived from Myrtus communis L. (MEO) is against HCoV-229E HCoV-OC43 virus infections comparison two FDA-approved...
Abstract Objective Lip plumpers should enhance lip volume. It has been shown that no noticeable result was obtained after long term use of these products. The present study carried out to assess plumpers’ short effectiveness within 2 h from application. Methods Effectiveness assessed using non‐invasive techniques. effect on vascularisation analyzed with the Mexameter MX 16 ® , and volume enhancing by anthropometric measures profilometry analysis 3D scanning electron microscope ( SEM ) images...
The ectopic nail (EN) is an additional located in abnormal site. It belongs to the onycho-heterotopia, a rare condition whose pathogenesis indeterminate. This article illustrates clinical-morphological and dermoscopic points of view, diagnostic criteria, possible pathogenesis, surgical treatment this pediatric onychoheterotopia.
Introduction . In the last decades, in dermo-cosmetic field, a lot of cosmetic products, invasive treatments and medical devices were popping up to improve aged skin. Recently several cheap innovative products called anti-wrinkle pad adhesive appeared but their efficiency against winkles is not really certain. Theoretically this product intended reduce local muscular contraction getting reduction existing forming new dynamical winkles. Commercial advertisements claims that utilization pads...