A5029683261- Colorectal Cancer Surgical Treatments
- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Microscopic Colitis
- Artificial Intelligence in Healthcare and Education
- Appendicitis Diagnosis and Management
- S100 Proteins and Annexins
- Topic Modeling
- Cardiac, Anesthesia and Surgical Outcomes
- Anorectal Disease Treatments and Outcomes
- Enhanced Recovery After Surgery
- Abdominal Surgery and Complications
- Colorectal Cancer Screening and Detection
- Wound Healing and Treatments
- Autoimmune and Inflammatory Disorders
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- High Altitude and Hypoxia
- Advanced X-ray and CT Imaging
- Esophageal and GI Pathology
- Stoma care and complications
- Nanoplatforms for cancer theranostics
- Esophageal Cancer Research and Treatment
Technical University of Munich
2018-2025
Klinikum rechts der Isar
2018-2025
Technical University of Denmark
2020
Heidelberg University
2014-2016
Ischemic stroke results in disruption of the blood-brain barrier (BBB), edema formation and neuronal cell loss. Some neuroprotective factors such as vascular endothelial growth factor (VEGF) favor formation, while others erythropoietin (Epo) can mitigate it. Both are controlled by hypoxia inducible transcription (HIF) activity prolyl hydroxylase domain proteins (PHD). We hypothesize that activation adaptive hypoxic response inhibition PHD neuroprotection prevention leakage. Mice, subjected...
Despite primary conservative therapy for Crohn's disease, a considerable proportion of patients ultimately needs to undergo surgery. Presumably, due the increased use biologics, number surgeries might have decreased. This study aimed delineate current case numbers and trends in surgery era biological disease.Nationwide standardized hospital discharge data (diagnosis-related groups statistics) from 2010 2017 were used. All who admitted as inpatient disease cases Germany included. Time-related...
The purpose of this retrospective study was to evaluate the value contrast-enhanced computed tomography (CE-CT) image features at baseline and after neoadjuvant chemotherapy in predicting histopathological response patients with adenocarcinoma gastroesophageal junction (GEJ). A total 105 a diagnosis GEJ were examined by CE-CT preoperatively chemotherapy. All underwent surgical resection. Histopathological parameters tumor regression grading according Becker et al. collected 93 patients. Line...
Abstract Aim Anastomotic leakage (AL) is one of the most dreaded complications in colorectal surgery. In 2013, International Classification Diseases code K91.83 for AL was introduced Germany, allowing nationwide analysis rates and associated parameters. The aim this population-based study to investigate current incidence, risk factors, mortality, clinical management, costs Methods A data query performed based on diagnosis-related group all hospital cases inpatients undergoing colon or...
Exploring the generative capabilities of multimodal GPT-4, our study uncovered significant differences between radiological assessments and automatic evaluation metrics for chest x-ray impression generation revealed bias.
Abstract Background Although in most patients with inflammatory bowel diseases, conservative therapy is successful, a significant proportion of still require surgery once their lifetime. Development safe perioperative treatment to dampen colitis activity without disturbance anastomotic healing an urgent and unmet medical need. Annexin A1 (ANXA1) has been shown be effective reducing activity. Herein, nanoparticle-based approach was used for analysis the effects ANXA1 on resolution...
Importance Differentiating between malignant and benign etiology in large-bowel wall thickening on computed tomography (CT) images can be a challenging task. Artificial intelligence (AI) support systems improve the diagnostic accuracy of radiologists, as shown for variety imaging tasks. Improvements performance, particular reduction false-negative findings, may useful patient care. Objective To develop evaluate deep learning algorithm able to differentiate colon carcinoma (CC) acute...
Abstract Prevention of intestinal fibrosis remains an unresolved problem in the treatment Crohn’s disease (CD), as specific antifibrotic therapies are not yet available. Appropriate analysis severity is essential for assessing therapeutic efficacy potential drugs. The aim this study was to develop observer-independent method quantify surgical specimens from patients with CD using structural extracellular matrix (ECM). We performed fractal fibrotic and control histological sections surgery (n...
Imaging phantoms were scanned twice on 3 computed tomography scanners from 2 different manufactures with varying tube voltages and currents. Phantoms segmented, features extracted using PyRadiomics a pretrained CNN. After standardization the concordance correlation coefficient (CCC), mean feature variance, range, of variant calculated to assess robustness. In addition, cosine similarity was for vectorized activation maps an exemplary phantom. For in vivo comparison, radiomics CNN 30 patients...
Abstract Background Anastomotic leakage represents a major complication following resections in colorectal surgery. Among others, intestinal inflammation such as inflammatory bowel disease is significant risk factor for disturbed anastomotic healing. Despite technical advancements and several decades of focused research, the underlying mechanisms remain incompletely understood. Animal experiments will backbone this research near future. Here, instructions on standardized reproducible murine...
Abstract Background Pancreatic cancer is often accompanied by wasting conditions. While surgery the primary curative approach, it poses a substantial risk of postoperative complications, hindering subsequent treatments. Therefore, identifying patients at high for complications and optimizing their perioperative general condition crucial. Sarcopenia other body composition abnormalities have shown to adversely affect surgical oncological outcomes in various patients. As most pancreatic tumours...
Crohn's disease (CD) is characterized by relapsing intestinal inflammation. The anti-inflammatory protein annexin A1 (ANXA1) has been linked to inflammatory processes in the gut.To examine ANXA1 expression patterns inflamed intestine of patients with CD and associate capacity characteristics.Surgical specimens operated between 2003 2015 were examined. Immunohistochemistry immunofluorescence performed delineate expression. Those pronounced included further analysis qPCR. mRNA ratio...
Abstract Purpose To evaluate the impact of a structured tutorial on use large language model (LLM)-based search engine radiology residents’ performance in LLM-assisted brain MRI differential diagnosis. Materials & Methods In this retrospective study, nine residents determined three most likely diagnoses for sets ten cases with challenging yet definite Each set was assessed 1) support conventional internet search, 2) using an LLM-based (© Perplexity AI) without prior training, or 3) LLM...
Targeted perioperative therapeutics supporting anastomotic healing during colitis are an urgent medical need. This study aimed to develop and evaluate a novel nanoparticle (NP)-based drug delivery system for improving in Inflammatory bowel disease (IBD) patients following surgery. We developed pectin-coated polymeric NPs encapsulating the inflammation-resolving peptide Ac2-26. These designed survive gastric passage, facilitate localized release colon via microbial pectinase degradation, bind...
High-dose glucocorticoid treatment has been identified as a risk factor for anastomotic leakage in patients with inflammatory bowel disease [IBD] undergoing resection surgery. By contrast, active during surgery is also associated elevated morbidity. Perioperative low-dose might be beneficial regarding postoperative outcomes by controlling activity. The present study the first to investigate dose-dependent effect of perioperative prednisolone therapy murine IBD model combining dextran sodium...
Abstract Purpose Modern non-operative management of diverticulitis consists a complex therapeutic regimen and is successful in most cases even complicated diverticulitis. Still, certain proportion patients requires urgent surgery due to failure the conservative approach. This study aims identify predictors for treatment with need subsequent resection during acute episode. Methods A single-centre retrospective cohort was performed at our tertiary centre including (characterized by localized...
Reliable markers to predict or diagnose anastomotic leakage (AL) of stapled circular anastomoses following colorectal resections are an important clinical need. Here, we aim quantitatively investigate the morphology rings as early available prognostic marker for AL and compare them established inflammatory markers. We perform a prospective single-center cohort study, including patients undergoing anastomosis between August 2020 2021. The predictive value ring configuration...
ABSTRACT Although medical treatment is sucessful in most cases patients with inflammatory bowel diseases (IBD), a percentage of require surgical resection diseased segments at least once their lifetime. Healing success the intestinal anastomosis high risk, especially presence acute inflammation. Failure anastomotic healing life-threatening complication and causes socioeconomic costs. Common anti-inflammatory medications can have detrimental effects on wound healing. Thus, targeted...