This retrospective cohort study examined 143/39,895 (0.36%) consecutive born-before-arrival (BBA) births. The incidence of BBA births doubled from 0.26% in 2005 to 0.5% 2009. increase was mainly attributed the non-Irish nationals and patients low socioeconomic groups attending for antenatal care. Poor social background often coupled with current or past substance misuse and/or a diagnosis an infectious disease. While there no excess maternal morbidity, perinatal mortality rate among...

The number of pregnant women with opioid use disorder (OUD) has quadrupled from 1999 to 2014. Current first line treatment for OUD in pregnancy is methadone increasing support buprenorphine. Limited data exist on buprenorphine/naloxone despite it being standard therapy the non-pregnant individuals. aim this study was compare neonatal withdrawal syndrome (NOWS) prevalence and characteristics among neonates born prescribed buprenorphine/naloxone.This a retrospective cohort analysis...

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated hepatic disorder characterized by pruritus in the setting elevated serum bile acids (BA). Risk factors for disease include preexisting hepatobiliary disease, personal or family history ICP, and advanced maternal age. Recent data suggests that patients with severe ICP (BA ≥100 μmol/L) have higher risk adverse outcomes including stillbirth.This was retrospective cohort study diagnosed between 2012 2019 at tertiary referral...

Predicting progressive disease in low-grade cervical cytology.

Abstract Background: The umbilical coiling index (UCI) is a measure of the number coils in cord relation to its length. Hypercoiled cords with UCI >0.3 coils/cm have been associated adverse fetal and neonatal outcomes. Aims: primary aim determine accuracy measured on second trimester ultrasound predicting at birth. secondary outcome investigate association between hypercoiling prenatal maternal, Methods: This was prospective cohort study uncomplicated singleton pregnancies. Seventy two...

Background Preeclampsia (PE) is a pregnancy-specific vascular endothelial disorder characterized by multi-organ system involvement. This includes the maternal kidneys, with changes such as continuous vasospasm of renal arteries and reduced blood flow. However, it unclear whether similar are seen in fetus. study sought to compare artery impedance fetuses women without PE. Methods was prospective Doppler assessment fetal 48 singleton fetuses. The group PE consisted 24 appropriately grown...

To identify rates of fetal autopsy in the United States as well demographic and clinical characteristics related to consent after stillbirth.This is a population-based retrospective cohort study using U.S. death certificates for stillborn fetuses (20 weeks gestation or more) delivered between January 2014 December 2016. Multiple gestations were excluded. Fetal calculated by gestational age, maternal self-reported race ethnicity, education, having at least one living child. Multivariate...

Limited data exists on the temporal trend of Sars-CoV-2 immunologic response and duration protection following natural infection. We sought to investigate presence serum antibodies in obstetrical healthcare workers (HCW) serial assessments over a 6-month period, assess rates vaccine acceptance reported side effects among this cohort.

Fetal growth restriction (FGR) is associated with adverse perinatal outcomes. Pre-eclampsia (PreE) increases the morbidity and mortality. The structure of umbilical cord in setting FGR PreE understudied. This study aimed to examine changes (UC) composition pregnancies complicated by PreE. UC from gestational age-matched isolated (n = 5), FGR+PreE 5) controls were collected, a portion was processed for histologic proteomic analysis. Manual segmentation analysis performed measure cross-section...

Objective To investigate whether women using intravaginal progesterone suppositories for preterm birth prevention during pregnancy will have lower rates of group B streptococcus ( GBS ) colonisation at term, compared with receiving intramuscular 17‐alpha ‐ hydroxyprogesterone caproate. Design This was a retrospective observational cohort study who were prescribed progestogen their prevention, and delivered term. Setting A tertiary referral hospital in central Ohio. Population Patients...

Abstract Objective This study aimed to determine if intrapartum placement of an intrauterine pressure catheter (IUPC) is associated with increased rate surgical site infections in women undergoing a cesarean delivery. Study Design was secondary analysis the prospective observational Maternal–Fetal Medicine Units Network Vaginal Birth after Cesarean Registry. We compared patients and without IUPC use. A multivariable logistic regression performed evaluate for association between use...

To investigate the association between meconium-stained amniotic fluid (MSAF) and postcesarean surgical site infections.This was a secondary analysis of Maternal-Fetal Medicine Units Network (MFMU) Cesarean Registry. Women with singleton pregnancy attempting labor or induction labor, who ultimately had cesarean delivery, were included in study. Pregnancies complicated by MSAF (n = 4262) those did not have 13,850) compared. The primary outcome incidence SSI.A total 18,112 patients 4262 (38%)...

Coagulation disorders are rare causes of postpartum hemorrhage. Disturbances in coagulation should be suspected patients with a family history coagulopathy, those personal heavy menstrual bleeding, and persistent bleeding despite correction other causes. The coagulopathic conditions discussed include disseminated intravascular coagulation, platelet disorders, disturbances factors. These not overlooked the evaluation obstetric hemorrhage, as diagnosis appropriate treatment may prevent severe...

To assess the association between aspirin and glycemic control in diabetic, pregnant patients, risk for resistance those with poor across gestation taking low-dose (LDA) pre-eclampsia (PEC) prevention.We performed a secondary analysis of samples collected during Maternal-Fetal Medicine Units trial LDA PEC prevention. A subset insulin-controlled diabetic patient on placebo or 60 mg daily were evaluated. Glycosylated hemoglobin was measured at randomization, mid-second trimester, third...

Objective Isolated fetal ventriculomegaly is often an incidental finding on antenatal ultrasound. It benign in up to 90% of cases, although it can be associated with genetic, structural, and neurocognitive disorders. The literature suggests that over 40% isolated mild will resolve utero, but unclear if resolution decreases the risks. aim this study compare neonatal genetic outcomes persists or resolves subsequent Study Design This a retrospective cohort women diagnosed via ultrasound at...

This is a case of rapidly enlarging cutaneous pedunculated tumor on patient's thumb during her pregnancy. was excised and identified as hemangioma. A literature search possible hormonal factor in causing an accelerated growth this tumor.

To determine the utility of using total peripheral systemic vascular resistance assessed non-invasive cardiac monitor for individualizing duration postpartum magnesium sulfate in individuals with preeclampsia severe features. Single center pilot randomized controlled trial which singleton pregnant features were to 24 h per standard care (control group) or individualized based on reduction post-delivery (intervention group). Systemic was monitoring Cheetah® system. A 30 % (maintained 1 h)...

Background Untreated opioid misuse in pregnancy is associated with adverse outcomes. Limited information available on maternal and perinatal outcomes subsequent pregnancies for individuals initiated medication use disorder (MOUD) a prior pregnancy. Objective Evaluate neonatal MOUD Methods Historical cohort study including ≥2 between 2013 2020, received care our colocated multidisciplinary clinic >1 pregnancy, delivered at institution. Primary outcome was rate of preconception MOUD....