A5073190553- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Cardiovascular Issues in Pregnancy
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Neonatal and fetal brain pathology
- Fatty Acid Research and Health
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Reproductive System and Pregnancy
- Pulmonary Hypertension Research and Treatments
- COVID-19 Impact on Reproduction
- Infant Nutrition and Health
- Hemoglobinopathies and Related Disorders
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Cancer Risks and Factors
- Ectopic Pregnancy Diagnosis and Management
- Abdominal Trauma and Injuries
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heart Rate Variability and Autonomic Control
- Liver Disease and Transplantation
The Ohio State University
2014-2024
The Ohio State University Wexner Medical Center
2020-2022
Yale University
2006-2010
United States Department of Defense
2008
St. Vincent's Medical Center
1998
St. Luke's Hospital
1998
Several meta analyses have concluded n-3 fatty acids, including docosahexaenoic acid (DHA), reduce early preterm birth (EPB, < 34 weeks), however, the amount of DHA required is unclear. We hypothesized that 1000 mg per day would be superior to 200 mg, in most prenatal supplements.This randomised, multicentre, double-blind, adaptive-design, superiority trial was conducted three USA medical centres. Women with singleton pregnancies and 12 20 weeks gestation were eligible. randomization...
We sought to define the risk of neonatal respiratory distress syndrome (RDS) as a function both lecithin/sphingomyelin (L/S) ratio and gestational age. Amniotic fluid L/S data were collected from consecutive women undergoing amniocentesis for fetal lung maturity at Yale-New Haven Hospital January 1998 December 2004. Women included in study if they delivered live-born, singleton, nonanomalous infant within 72 hours amniocentesis. The probability RDS was modeled using multivariate logistic...
BackgroundIntention-to-treat analyses do not address adherence. Per protocol treat nonadherence as a deviation and assess if the intervention is effective followed.ObjectiveTo determine rate of early preterm birth (EPTB, <34 weeks gestation) (PTB, <37 in participants who adhered to randomly assigned docosahexaenoic acid (DHA) dose 1000 mg/day.Study designEleven hundred women with singleton pregnancy were enrolled before 20-weeks' gestation, provided capsule 200 mg/day DHA two additional...
Proinflammatory cytokines of placental or systemic origin are thought to play a central role in the pathophysiology preeclampsia. We sought estimate fractional excretion tumor necrosis factor (TNF)-alpha relationship proteinuria women with severe preeclampsia.In cross-sectional study, we evaluated serum and urine levels TNF-alpha 45 diagnosed preeclampsia (mean+/-standard error mean, gestational age 29.1+/-0.5 weeks). Forty-five healthy pregnant matched for parity, maternal age, at...
In Brief OBJECTIVE: To survey the uterine scar thickness by ultrasonography in women randomly assigned to one- or two-layer hysterotomy closure after primary cesarean delivery. METHODS: This was a randomized, blinded trial of with ultrasonographic follow-up. Thirty consecutive patients undergoing delivery were enrolled and hysterotomy. Ultrasound surveillance performed at baseline (before surgery) 48 hours, 2 weeks, 6 weeks post partum. RESULTS: Patient compliance postpartum protocol 90%,...
We hypothesized that abnormal fetal heart rate monitoring patterns (FHR-MPs) occur more often in pregnancies complicated by intra-amniotic inflammation. Therefore, our objective was to examine the relationships among FHR-MP abnormalities, inflammation and/or infection, acute histological chorioamnionitis, and early-onset neonatal sepsis (EONS) preterm birth. Additionally, ability of various FHR-MPs predict EONS investigated. from 87 singleton premature neonates delivered within 48 hours...
Placenta accreta spectrum is a group of disorders involving abnormal trophoblastic invasion to the deep layers endometrium and myometrium. accrete one major causes severe maternal morbidity, with increasing incidence in past decade mainly secondary an increase cesarean deliveries. Severity varies depending on depth invasion, most form, known as percreta, invading uterine serosa or surrounding pelvic organs. Diagnosis usually achieved by ultrasound, MRI sometimes used assess invasion....
Limited data exists on the temporal trend of Sars-CoV-2 immunologic response and duration protection following natural infection. We sought to investigate presence serum antibodies in obstetrical healthcare workers (HCW) serial assessments over a 6-month period, assess rates vaccine acceptance reported side effects among this cohort.
Woensdregt, K.; Norwitz, E. R.; Cackovic, M.; Paidas, M. J.; Illuzzi, J. L. Author Information
Elevated serum transaminase levels can have many different etiologies, especially in the pregnant patient. Hypoxic hepatitis is a distinct syndrome caused by decreased hepatic blood flow that presents with marked, but transient, increase liver enzymes. A 28-year-old woman, gravida 3, para 2 history of gastric bypass, presented second trimester bright red per rectum, syncope, and epigastric pain. Laboratory studies were significant for anemia, elevated enzymes, low platelets, raising concern...
Introduction: Fetal heart rate monitoring presents one of the few available methods for evaluating fetus prior to birth. However, current devices on market have significant shortcomings. We sought describe use and experiences with external fetal (EFM) among obstetrical providers.Materials methods: performed a cross-sectional survey in an academic medical center between April July 2017 including nurse, midwife, physician providers (n = 217) who were invited participate this study regarding...
Pulmonary hypertension (PH) due to left heart disease (World Health Organization (WHO) Group 2 PH) is the largest PH subgroup, however most reports of in pregnancy focus on patients with pulmonary arterial (WHO 1 PH). We evaluated outcomes across WHO subgroups. performed a retrospective single center cohort study maternal and fetal pregnant women (2004–2018). analyzed 70 pregnancies (30 ± 6 years-old), classified as (12 (17%)), (45 (64%)), 3 (4 (6%)) 5 (9 (13%)). Although no peripartum death...
Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic test used in trauma for goal-directed transfusion. However, there are limited data on baseline ROTEM parameters the U.S. obstetric population. Obtaining first step implementing massive transfusion protocol hemorrhage.
To determine the utility of using total peripheral systemic vascular resistance assessed non-invasive cardiac monitor for individualizing duration postpartum magnesium sulfate in individuals with preeclampsia severe features. Single center pilot randomized controlled trial which singleton pregnant features were to 24 h per standard care (control group) or individualized based on reduction post-delivery (intervention group). Systemic was monitoring Cheetah® system. A 30 % (maintained 1 h)...
Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary vascular resistance (PVR). Pregnancy in the setting of PAH associated with significant maternal morbidity and mortality, typically present during labor early postpartum. Historically, observed mortality has been as high 56%. However, improved recognition, understanding, treatment PAH, reassessment outcomes increasing interest. This retrospective observational case series all women diagnosis moderate to...