A5061048084- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Musculoskeletal pain and rehabilitation
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Berberine and alkaloids research
- Peripheral Neuropathies and Disorders
- Cannabis and Cannabinoid Research
- Toxin Mechanisms and Immunotoxins
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Biotechnology and Related Fields
- Occupational Health and Performance
- Spondyloarthritis Studies and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Retinal and Optic Conditions
- Statistical Methods in Clinical Trials
- Liver Disease and Transplantation
- Medical Imaging and Pathology Studies
- Viral Infections and Immunology Research
- Biomedical and Engineering Education
- Dengue and Mosquito Control Research
- Hepatitis Viruses Studies and Epidemiology
Pontificia Universidad Católica de Chile
2010-2025
University of Atlántico
2020
Universidad Libre de Colombia
2020
Boston University
2015-2017
National Institute for Health Research
2017
Versus Arthritis
2017
University of Manchester
2017
Universidad del Desarrollo
2015
Instituto Nacional de Salud Pública
2008
Breda University of Applied Sciences
1994
Abstract Background Inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been widely implemented in low- and middle-income countries. However, immunogenicity immunocompromised patients has not established. Herein, we aimed to evaluate immune response CoronaVac vaccine these patients. Methods This prospective cohort study included 193 participants with 5 different immunocompromising conditions 67 controls, receiving doses of 8–12 weeks before enrollment. The...
Rheumatic diseases (RDs) encompass a diverse group of systemic inflammatory conditions autoimmune origin. These diseases, such as rheumatoid arthritis (RA), spondyloarthritis (SpA), and connective tissue affect millions people globally. They significantly reduce quality life can lead to severe disability premature death.
Abstract Although we know chronic pain (CP) affects approximately 30% of people in developed countries, data from Latin America are scarce. Moreover, prevalence specific CP conditions, such as noncancer (CNCP), fibromyalgia (FM), and neuropathic (NP), is unknown. To estimate them Chile, prospectively enrolled 1945 participants (61.4% women 38.6% men), aged 38 to 74 years, an agricultural town who answered a Pain Questionnaire, the Fibromyalgia Survey Douleur Neuropathique 4 (DN4) identify...
Objective. To evaluate whether patients with RA who belong to the spectrum of fibromyalgic (FRA) have an impaired response treatment measured by traditional activity scores. Methods. Patients from ESPOIR cohort were analysed. This prospective included 813 early arthritis not initially receiving DMARDs. Among 697 met classification criteria, we studied two groups, one and other without FRA. The following endpoints compared at 6, 12 18 months using a mixed linear regression model: 28-joint DAS...
The aim of this study was to evaluate the psychometric properties Chilean version Fibromyalgia Survey Questionnaire (FSQ).Women with fibromyalgia (FM; n = 214), women rheumatoid arthritis (RA; 97), and without chronic pain (being followed by Gynecology, G; 117) from Red de Salud UC CHRISTUS (Santiago, Chile) participated. Women FM completed FSQ, Impact (Revised Version), Numerical Pain Rating Scale, Catastrophizing Vigilance Awareness Questionnaire, Patient Health 15, Short-Form Survey. Two...
Dengue virus (DENV) is transmitted to humans by Aedes sp. mosquitoes. Little known about the cellular and molecular interactions between mosquito. The identification of resistance mechanisms could provide insight for development control strategies based on genetic manipulation.To determine effect nitric oxide (NO) donors/inhibitors DENV replication in aegypti Anopheles albimanus.Ae. An. albimanus were fed with a blood suspension supplemented NO; was assessed immunofluorescence, RT-PCR...
Chronic musculoskeletal pain (CMP) causes significant health loss worldwide. Given that cultural factors may affect processing, it is key to have more information regarding CMP epidemiology in Latin America. In this study, we aimed determine the prevalence of and chronic widespread (CWP) Chile.This was a cross-sectional survey study. We used data recollected 2016-2017 Chilean National Health Survey, nationwide household survey. Our study population included subjects older than 14 years...
Objective. Subjects with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular disease, which is their leading cause death. Conflicting evidence exists regarding the efficacy aspirin (ASA) as primary prevention. We evaluated whether a protective association between ASA and myocardial infarction (MI) in RA subjects. Methods. In United Kingdom, persons age ≥ 60 years receive free by prescription 75% use prescription. population-based The Health Improvement Network database...
Objective. Genetic and environmental backgrounds influence the development of rheumatoid arthritis (RA). In Latin America, epidemiologic data are scarce. We aimed to determine prevalence RA in Chile a population-based study. Methods. The National Health Survey was cross-sectional household survey with stratified multistage probability sample 6233 participants performed between August 2016 March 2017. A screening instrument for applied random 3847 subjects > 30 years old. Positive defined...
Background: The Health Assessment Questionnaire Disability Index (HAQDI) is one of the main instruments used to evaluate functional status in rheumatoid arthritis (RA).
Symptom management in rheumatoid arthritis (RA) remains a complex challenge. Widespread use of cannabis-based medicines for myriad symptoms has fostered rheumatology patients' interest. However, their safety and efficacy RA remain unclear.The aim this study was to perform structured summary the body evidence order determine whether cannabis, cannabis-derived products, synthetic cannabinoids are an effective treatment arthritis.An electronic search Epistemonikos database performed identify...
Coronary thrombosis as a manifestation of the antiphospholipid syndrome is very uncommon. We report 25 year-old male without known cardiovascular risk factors that suffered an acute myocardial infarction initial syndrome. His coronary angiogram demonstrated single thrombotic lesion in anterior descending artery atheromatosis. Anticardiolipin, anti B2 Glycoprotein I antibodies, and lupus anticoagulant were all positive. Besides usual management thrombosis, patient was treated with permanent...
Pseudotumor cerebri secondary to Behçet disease. Report of one caseThe classical manifestations disease are mouth and genital ulcers, cutaneous lesions ocular involvement.The central nervous system is affected in 5 59% the cases, usually form meningoencephalitis or sinus venous thrombosis.We report a 17-year-old female presenting with two weeks history progressive headache, nausea blurred vision.An initial magnetic resonance was normal.Fifteen days later she admitted hospital due progression...
Fibromyalgia and major depression frequently co-occur. Patients with both conditions have a worse prognosis higher disability, their treatment options are scarce. Behavioral activation (BA) may be an especially useful intervention for these patients, as it targets mechanisms of action that seem to common disorders. Nevertheless, its efficacy has not been examined in people conditions. We describe the design rationale randomized clinical trial aimed evaluate adding BA (applied groups) usual...
<h3>Background:</h3> Genetic and environmental backgrounds influence the development of rheumatoid arthritis (RA) its frequency has regional variations. In Latin America epidemiologic data are scarce. <h3>Objectives:</h3> We aimed to determine prevalence RA in Chile as part National Health Survey (ENS, Encuesta Nacional de Salud). <h3>Methods:</h3> ENS was a cross-sectional household survey with stratified multistage probability sample 6,233 participants performed between August 2016 March...