A5078300336- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- Autoimmune and Inflammatory Disorders Research
- Lung Cancer Treatments and Mutations
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Reproductive System and Pregnancy
- Chronic Lymphocytic Leukemia Research
- Inflammatory Bowel Disease
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Lung Cancer Research Studies
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- FOXO transcription factor regulation
- Air Quality and Health Impacts
Fundación Pública Galega de Medicina Xenómica
2022-2025
Servicio Gallego de Salud
2019-2025
Universidad Autónoma de Chile
2016-2025
Instituto de Investigación Sanitaria de Santiago
2019-2024
Universidade de Santiago de Compostela
2023
Centro de Investigación Biomédica en Red de Cáncer
2021
Complexo Hospitalario Universitario A Coruña
2019-2020
Institut Pere Mata
2016-2019
Institut d'Investigació Sanitària Pere Virgili
2016-2019
Universitat Rovira i Virgili
2019
Salivary microRNAs (miRNAs) are of high interest as diagnostic biomarkers for non-oral cancer. However, little is known about their value colorectal cancer (CRC) detection. Our study aims to characterize salivary miRNAs in order identify non-invasive markers CRC diagnosis. The screening 754 was performed saliva samples from 14 and 10 healthy controls. differential expressed were validated by RT-qPCR 51 CRC, 19 adenomas 37 Receiver operating characteristic (ROC) curves logistic regression...
ABSTRACT Killer immunoglobulin-like receptors (KIRs) are related to the activation and inhibition of NK cells may play an important role in innate response against infection with viruses such as hepatitis C virus (HCV). We examined whether different combinations KIRs their HLA class I ligands influenced combined treatment (pegylated alpha interferon ribavirin) patients infected by HCV. A total 186 consecutive diagnosed chronic HCV were analyzed. Seventy-seven exhibited RNA levels at 6 months...
CD4 T lymphocytes expressing CD8dim (DP: CD8dim) or NKG2D represent cytotoxic effector populations, which have been involved in viral infections and chronic diseases. The frequency of DP cells was analyzed by flow cytometry 300 consecutive HIV-infected patients 50 healthy controls. expression memory/effector markers were also studied, addition to virologic genetic factors T-cell expansion. showed a significantly higher than controls, mainly with advanced disease. Expansion related appearance...
We analyzed the association between HLA polymorphisms and susceptibility to SARS‐CoV‐2 infection disease severity. Genotyping data from a total of 9373 COVID‐19‐positive cases Spanish Coalition Unlock Research on Host Genetics COVID‐19 (SCOURGE) consortium 5943 population controls were included in study. found an alleles HLA‐B*14:02 HLA‐C*08:02 with lower risk ( p = 0.006, OR 0.84, 95% CI [0.75–0.95], 0.024, 0.86, [0.78–0.95], respectively). also HLA‐A*11:01 HLA‐C*04:01 associated severity...
Rheumatic diseases (RDs) encompass a diverse group of systemic inflammatory conditions autoimmune origin. These diseases, such as rheumatoid arthritis (RA), spondyloarthritis (SpA), and connective tissue affect millions people globally. They significantly reduce quality life can lead to severe disability premature death.
The killer cell immunoglobulin-like receptors (KIRs) form a group of regulatory molecules that specifically recognize HLA class I molecules. aim this study was to analyze the possible contribution KIR3DL1 and KIR3DS1 alleles, in addition HLA-B27, susceptibility ankylosing spondylitis (AS) population individuals from Spain.We genotyped alleles 2 cohorts patients with AS healthy control subjects. In total, 270 435 healthy, HLA-B27-positive matched subjects Spain were enrolled. by...
Immune checkpoint inhibitors, such as pembrolizumab, are revolutionizing therapeutic strategies for different cancer types, including non‐small‐cell lung (NSCLC). However, only a subset of patients benefits from this therapy, and new biomarkers needed to select better candidates. In study, we explored the value liquid biopsy analyses, circulating free DNA (cfDNA) tumour cells (CTCs), prognostic or predictive tool guide pembrolizumab therapy. For purpose, total 109 blood samples were...
Objective To analyze the distribution of HLA-B alleles and to investigate their contribution in susceptibility spondyloarthropathies (SpA) a sample population from Zambia, order determine relationship between some development ankylosing spondylitis (AS), reactive arthritis (ReA), or undifferentiated SpA (uSpA). Methods We selected 72 patients with found that 46 had uSpA, 23 ReA, 3AS.We also 92 matched controls; 55 these human immunodeficiency virus type I (HIV-I) infection. Results...
MET alterations may provide a potential biomarker to evaluate patients who will benefit from treatment with inhibitors. Therefore, the purpose of present study is investigate utility liquid biopsy-based strategy assess in cancer patients. We analyzed amplification circulating free DNA (cfDNA) 174 and 49 healthy controls demonstrated accuracy analysis detect its alteration Importantly, significant correlation between cfDNA concentration copy number (CN) (r = 0.57, p <10-10) was determined....
Lack of biomarkers for treatment selection and monitoring in small cell lung cancer (SCLC) patients with the limited therapeutic options, result poor outcomes. Therefore, new prognostic are needed to improve their management. The value cell-free DNA (cfDNA) circulating tumor cells (CTCs) have been less explored SCLC.We quantified cfDNA 46 SCLC at different times during first-line chemotherapy or chemo-immunotherapy. Moreover, CTCs were analyzed 21 before therapy onset using CellSearch®...
Background: Lung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer associated with high mortality rates. We aimed to utilize single-cell multiomics analysis identify the key molecules involved in ubiquitination modification, which plays role LUAD development and progression. Methods: use systematic approach analyze LUAD-related bulk transcriptome datasets from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases. Single-cell RNA sequencing (scRNA-seq) data were...
Large genome-wide analysis studies (GWAS) and meta-analyses have dramatically increased our knowledge of the genetic risk factors inflammatory bowel disease (IBD), identifying at least 163 loci. The endoplasmic reticulum aminopeptidase-2 ( ERAP2) gene has been reported as a potential candidate for IBD. GWAS also shown associations between ERAP single nucleotide polymorphisms (SNP) loci susceptibility to several autoimmune diseases, ERAP1 ERAP2 are related HLA class I-associated including...