A5058259602- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- RNA Research and Splicing
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- interferon and immune responses
- Extracellular vesicles in disease
- Statistical Methods in Clinical Trials
- Metal complexes synthesis and properties
- Cancer Mechanisms and Therapy
- Synthesis of Tetrazole Derivatives
- CAR-T cell therapy research
- Mathematical Biology Tumor Growth
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
Health Research Institute of the Balearic Islands
2015-2025
Hospital Universitario Son Espases
2014-2025
Research Institute of Health Sciences
2009-2024
Universitat de les Illes Balears
2009-2021
Servei de Salut de les Illes Balears
2010-2016
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2011
Institut d'Investigació Biomédica de Bellvitge
2004-2009
Institut Català d'Oncologia
2004-2009
University of Michigan
2009
University of Cambridge
2009
Notch has been linked to beta-catenin-dependent tumorigenesis; however, the mechanisms leading activation and contribution of pathway colorectal cancer is not yet understood. By microarray analysis, we have identified a group genes downstream Wnt/beta-catenin (down-regulated when blocking Wnt/beta-catenin) that are directly regulated by (repressed gamma-secretase inhibitors up-regulated active Notch1 in absence beta-catenin signaling). We demonstrate Wnt cells through beta-catenin-mediated...
Introduction: Soft tissue sarcomas (STS) are a group of rare malignancies with limited treatment options and persistent lack effective therapies. Despite the heterogeneous nature STS, canonical WNT/β-catenin signalling pathway has been associated sarcomagenesis, also initiation progression other cancers. Methods: Eight patient-derived primary cultures representing different STS histological subtypes were characterized by immunohisto(cyto)chemistry, activation, Next-Generation Sequencing...
Summary The FOXO3 (Forkhead/winged helix box class O 3) transcription factor is a crucial regulator of haematopoietic cell fate that controls proliferation and apoptosis, among other processes. Despite the central role as tumour suppressor phosphatidylinositol 3‐kinase (PI3K)/AKT effector, little known about its involvement in mantle lymphoma (MCL) biology. This study investigated expression activity MCL lines primary cultures. We analysed key FOXO regulators targets, studied effect...
Purpose: Nilotinib plus doxorubicin showed to be synergistic regarding apoptosis in several sarcoma cell lines. A phase I/II trial was thus designed explore the feasibility of nilotinib as coadjuvant by inhibiting MRP-1/P-gp efflux activity. The I part study is presented here.Patients and Methods: 400 mg/12 hours administered fixed dose from day 1 6, on 5 each cycle. Three escalation levels for at 60, 65, 75 mg/m2 were planned. Cycles repeated every 3 weeks a total 4 cycles. Eligible...
MET alterations may provide a potential biomarker to evaluate patients who will benefit from treatment with inhibitors. Therefore, the purpose of present study is investigate utility liquid biopsy-based strategy assess in cancer patients. We analyzed amplification circulating free DNA (cfDNA) 174 and 49 healthy controls demonstrated accuracy analysis detect its alteration Importantly, significant correlation between cfDNA concentration copy number (CN) (r = 0.57, p <10-10) was determined....
MDM2 is a critical negative regulator of the p53 tumor suppressor protein. Selected sarcoma subtypes are being treated with Trabectedin in second line, which promotes DNA damage and p53-dependent apoptosis. The aim this study was to evaluate improvement response inhibitors soft tissue sarcomas. antitumor effects Trabectedin, Nutlin-3A RG7112 as single agents or combination were examined vitro. significantly synergized MDM2-amplified liposarcoma cells, representing promising new therapeutic...
The Wnt signaling pathway is an important cellular mechanism for regulating differentiation processes as well cell cycle events, and different inhibitors of this pathway, example, PRI-724, are showing promising results in clinical trials treatment advanced pancreatic adenocarcinoma or ovarian cancer. Growing evidence suggests that may also be crucial tumorigenesis progression soft tissue sarcomas (STS), a malignant neoplasm with few therapeutic options at state. Our study several STS lines...
Abstract Recent studies have suggested that APC loss alone may be insufficient to promote aberrant Wnt/β‐catenin signalling. Our aim was comprehensively characterize Wnt signalling components in a set of APC‐associated familial adenomatous polyposis (FAP) tumours. Sixty adenomas from six FAP patients with known pathogenic mutations were included. Somatic and KRAS mutations, β‐catenin immunostaining, qRT‐PCR APC, MYC, AXIN2 SFRP1 analysed. Array‐comparative genomic hybridization (aCGH) also...
Abstract We report the synthesis and biological evaluation of a new series oligosquaramide‐based macrocycles as anticancer agents. Compound 7 , considered representative this series, exhibited significant antiproliferative activity against NCI‐60 human tumor cell line panel, with IC 50 values ranging from 1 to 10 μ M . The results show that sensitivity cyclosquaramides is clearly dependent on type, underscoring degree selectivity. observed effects appear be related deregulation protein...
Mantle Cell Lymphoma (MCL) is an aggressive lymphoma subtype that accounts for 6-8% of non-Hodgkin lymphomas. The disease mostly incurable and characterized by a continuous pattern relapse. Major changes have recently been implemented in the management MCL, but relapses still mark this as challenge clinicians. We previously reported efficacy GemOx-R (Gemcitabine, Oxaliplatin Rituximab) patients with refractory relapsing MCL. present results larger series longer follow-up including high-risk...
Objectives: The main objectives of the study were (1) to set-up a droplet digital PCR (ddPCR) assay for non-invasive detection G719S EGFR mutation in NSCLC patients; (2) determine limits ddPCR and (3) compare COBAS® System quantification plasma. Materials Methods: Blood samples collected from 22 patients diagnosed with advanced NSCLC. Then, plasma ctDNA was extracted Qiagen Circulating Nucleic Acids kit quantified by QuantiFluor® dsDNA System. mutational carried out QX200 Droplet Digital...
Soft tissue sarcomas (STS) are malignant tumors of mesenchymal origin and represent around 1% adult cancers, being a very heterogeneous group with more than 50 different subtypes. The Wnt signaling pathway is involved in the development regulation, self-renewal, differentiation stem cells, plays role sarcomagenesis. In this study, we have tested pharmacologic inhibition mediated by disruption TCF/β-catenin binding AXIN stabilization, first strategy efficient reducing cell viability...
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level, and they have been described as being associated with tumor prognosis. Here, miRNA profiling was planned to explore new molecular prognostic biomarkers in localized intestinal high-risk GIST. Paraffin blocks of 14 86 patients were used discovery expansion sets, respectively. GeneChip v3.0 employed identify miRNAs differentially expressed between relapsed non-relapsed...
Abstract A newborn presented with extensive rounded and velvety epidermal nevus (RAVEN) a genetic study of the cutaneous lesions revealing heterozygous mutation in FGFR2 (p.Cys382Arg). By 2 years age, patient developed hair heterochromia autism spectrum disorder. Although RAVEN was initially associated fibroblast growth factor 3 ( FGFR3 ) mutations, three cases have been identified mutations (p.Ser252Trp) one case linear keratinocytic nevi has same as our patient. This strongly supports...