Annet Nakaweesa
A5070872166- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Health Policy Implementation Science
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
World Health Organization - Uganda
2024
BackgroundNon-sputum-based triage tests for tuberculosis are a priority ending tuberculosis. We aimed to evaluate the diagnostic accuracy of late-prototype Xpert MTB Host Response (Xpert HR) blood-based assay.MethodsWe conducted prospective study among outpatients with presumed in outpatient clinics Viet Nam, India, Philippines, Uganda, and South Africa. Eligible participants were aged 18 years or older reported cough lasting at least 2 weeks. excluded those receiving treatment preceding 12...
Sputum-based testing is a barrier to increasing access molecular diagnostics for tuberculosis (TB). Many people with TB are unable produce sputum, and sputum processing increases assay complexity cost. Tongue swabs emerging as an alternative but performance limits uncertain.
BackgroundDecentralised molecular testing for tuberculosis could reduce missed diagnoses and losses to follow-up in high-burden settings. The aim of this study was evaluate the cost cost-effectiveness Xpert Performance Evaluation Linkage Tuberculosis Care (XPEL-TB) strategy, a multicomponent strategy including decentralised tuberculosis, Uganda.MethodsWe conducted costing analysis nested pragmatic cluster-randomised trial onsite (decentralised) versus hub-and-spoke (centralised) with MTB/RIF...
Abstract Background Recognizing new and improved diagnostics as a key step to reducing the global tuberculosis (TB) burden, World Health Organization (WHO) publishes target product profiles (TPPs) guide development of novel TB diagnostics; however, TPPs have not included preferences people undergoing testing. Understanding their is crucial for optimizing acceptability uptake diagnostic services. Design/methods We conducted discrete choice experiment (DCE) among adults with presumptive or...
Abstract Background Delays in diagnosis and treatment of tuberculosis (TB) remain common high-burden countries. To improve case detection, substantial investments have been made to scale-up Xpert MTB/RIF (Xpert), a cartridge-based nucleic acid amplification test that can detect TB within 2 hours, as replacement for sputum smear microscopy. However, the optimal strategy implementation testing remains unclear. Methods The Performance Evaluation Linkage Tuberculosis Care (XPEL-TB) trial uses an...
Public randomization ceremonies have been proposed as a strategy to strengthen stakeholder engagement and address concerns misconceptions associated with trial randomization. However, there are few published examples that describe how conduct public ceremony meaningful or such impact perceptions about the process. Cluster for GeneXpert Performance Evaluation Linkage Tuberculosis Care (XPEL-TB) was conducted at attended by 70 stakeholders in Kampala, Uganda. Presentations given Acting...