A5071039694- Neonatal Respiratory Health Research
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Heart Failure Treatment and Management
- Ion channel regulation and function
- Ion Channels and Receptors
- Anesthesia and Neurotoxicity Research
- Nutritional Studies and Diet
- Tuberculosis Research and Epidemiology
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Membrane Separation Technologies
- Advanced Sensor and Energy Harvesting Materials
- Pregnancy and preeclampsia studies
- Infant Nutrition and Health
- Hormonal Regulation and Hypertension
- Animal Genetics and Reproduction
- Infectious Diseases and Tuberculosis
- COVID-19 diagnosis using AI
- Heart Rate Variability and Autonomic Control
- Surface Modification and Superhydrophobicity
- Thermoregulation and physiological responses
- Neuroscience of respiration and sleep
- Lung Cancer Diagnosis and Treatment
- Dietary Effects on Health
University of California, San Francisco
2024-2025
Karolinska University Hospital
2024
Karolinska Institutet
2024
University of Utah
2024
San Diego State University
2020-2024
Stanford University
2020-2022
New York University
2021
San Diego State University, Imperial Valley Campus
2021
Lee Memorial Health System
2021
Instituto de Tecnologia de Alimentos
2015
BackgroundNon-sputum-based triage tests for tuberculosis are a priority ending tuberculosis. We aimed to evaluate the diagnostic accuracy of late-prototype Xpert MTB Host Response (Xpert HR) blood-based assay.MethodsWe conducted prospective study among outpatients with presumed in outpatient clinics Viet Nam, India, Philippines, Uganda, and South Africa. Eligible participants were aged 18 years or older reported cough lasting at least 2 weeks. excluded those receiving treatment preceding 12...
Elevated LDL-C, lipoprotein(a) [Lp(a)], and inflammation are associated with greater risk for atherosclerotic cardiovascular events. Consumption of individual nut types decreases these factors but knowledge about the effect mixed nuts on Lp(a) is limited. The objective this study was to determine effects consuming 42.5 g/day Lp(a), inflammatory markers in individuals overweight or obesity.In a 16-week randomized control trial, 29 participants obesity (BMI 25-40 kg/m2) consumed either...
Diagnosing childhood pulmonary tuberculosis (TB) is a challenge. This led the Uganda National Tuberculosis and Leprosy Program (NTLP) to develop clinical treatment decision algorithm (TDA) for children. However, there limited data on its accuracy, how it compares new World Health Organization (WHO) TB TDAs study aimed evaluate compare accuracy of 2017 NTLP diagnostic with 2022 WHO among We analyzed four years from children <15 old in Kampala, Uganda. Children were classified as per...
Abstract Some individual fruits have been widely researched for their effects on overall health and correlations with chronic diseases. The beneficial of mango supplementation metabolic diseases detected. However, research into consumption gut health, including the microbiome, is limited to processed preparations or peels. Our goal was examine fresh permeability proteins, bowel movement habits in overweight/obese individuals. In a 12‐week crossover design study, 27 participants consumed 100...
Assess management of neonatal abstinence syndrome (NAS) in California hospitals to identify potential opportunities expand the use best practices.We fielded an internet-based survey 37 questions medical directors or nurse managers at 145 birth California.Seventy-five participants (52%) responded. Most respondents reported having least one written protocol for managing NAS, but gaps included protocols pharmacologic management. Newer tools assessing NAS severity were not commonly used. About...
Preterm rabbits from 14 litters were delivered at 27 d gestation, anesthetized, and treated with surfactant birth, 15 min, or 30 min after the onset of mechanical ventilation. Doses ranging 0 to 100 mg/kg body weight given intratracheally ventilated for 45 birth. Pressure-volume curves dynamic compliances demonstrated that dose response progressively decreased delayed treatment. Following treatments 50 peak lung volumes 35 cm H2O increased by 49, 30, 8.4%, respectively over those untreated...
ABSTRACT Background Computer-aided detection (CAD) algorithms for automated chest X-ray (CXR) reading have been endorsed by the World Health Organization tuberculosis (TB) triage, but independent, multi-country assessment and comparison of current products are needed to guide implementation. Methods We conducted a head-to-head evaluation five CAD TB triage across seven countries. included CXRs from adults who presented outpatient facilities with at least two weeks cough in India, Madagascar,...
Studies were conducted to quantify ovine fetal and adult atrial natriuretic factor (ANF) metabolism. A total of 14 pregnant ewes with singleton fetuses prepared vascular catheters. In protocol 1, six (mean gestation, 131 +/- 1 days) received intravenous infusions synthetic human ANF (hANF, 100 ng.min-1.kg-1) for 60 min. Mean basal plasma levels increased from 180 44 pg/ml a steady-state level 1,233 192 pg/ml. 2, five 130 successive 40-min hANF at 5, 25, ng.min-1.kg-1. Although (522 135...
Pregnant women may be exposed to exercise, thermal, or gastrointestinal (hyperemesis) water loss, all of which commonly induce a greater than 10 mosmol increase in plasma osmolality. Although fetal osmolality is dependent on maternal osmolality, the impact dehydration and subsequent rehydration fetus has not been explored. Five pregnant ewes with singleton fetuses (136 +/- 1 day) were deprived for 36 h resulting significant (298 3.4 313 5.0 mosmol). In response dehydration, (297.0 4.1 309.3...
Abstract A major mechanism for Na + transport across epithelia occurs through epithelial channels (ENaC). ENaC is a multimeric channel consisting of three subunits (α, β, and γ). The α‐subunit critical function. In specific culture conditions, the rat submandibular gland cell line (SMG‐C6) demonstrates minimal properties exposure to dibutyryl cAMP (DbcAMP) up 48 h caused an elevation α‐ENaC mRNA protein expression amiloride‐sensitive short‐circuit current (I SC ). Here we examined early...
Abstract α‐ENaC expression and activity is regulated by a variety of hormones including β‐adrenergic agonists via the second messenger cAMP. We evaluated early intermediate pathways involved in up‐regulation SGK1 DbcAMP whether prerequisite for induction expression. Submandibular gland epithelial (SMG‐C6) cells treated with (1 mM) induced both mRNA protein DbcAMP‐stimulated was decreased actinomycin D expressions were attenuated PKA inhibitors (H‐89 KT5720). Inhibition PI3‐K either LY294002...
Heart disease, caused by atherosclerosis, is the leading cause of death. Maintaining vascular integrity crucial to reducing atherosclerosis risk. Mangos are rich in fiber, vitamins, minerals, and phytochemicals that may offer cardioprotective immune-boosting benefits. However, their effects on vasculature immune system adults with overweight obesity remain unclear. The objective this study was investigate mango consumption health function obesity. In a 12-week, crossover study, 27 obese...
Pages R40–R46: M. Gore Ervin, Michael G. Ross, Robert Castro, Dany Sherman, W. Lam, Loni Rosemary D. Leake, and Delbert A. Fisher. “Ovine fetal adult atrial natriuretic factor metabolism.” R42–R43: The mean residence time (MRT) values published were incorrect. Corrected are listed below: (See PDF)
Hydroponic food production in greenhouses is challenged by reduced exposure to ultraviolet (UV) light and beneficial soil microorganisms, which predisposes plants antioxidant deficiencies disease susceptibility. The objective of this study was investigate the effects UV compost tea treatment on hydroponically grown plants. Garnet Giant mustard greens were both indoor outdoor greenhouse settings, with without blocking supplementation tea. Plants outside produced more dry mass than those...
The syndrome of inappropriate secretion antidiuretic hormone is associated with head trauma; however, there are no reports concerning vasopressin levels in pediatric patients trauma. Urine eight children (mean ± SEM, age 7.5 1.6 years, range 1 to 15 years) was measured by radio-immunoassay during their hospitalization for values ten healthy 5.4 1.3 and hospitalized systemic antibiotic treatment infections (age 5.9 1.8 also were obtained. vasopressin, urine serum sodium concentration...
Glucocorticoids and mineralocorticoids modulate Na+ transport via epithelial channels (ENaC). The rat submandibular cell line, SMG-C6, expresses alpha-ENaC mRNA protein exhibits amiloride-sensitive when grown in low-serum (2.5%) defined medium, therefore, we examined the effects of altering composition SMG-C6 growth medium on ENaC expression function. No differences basal or short-circuit current (Isc) were measured across monolayers absence thyroid hormone, insulin, transferrin, EGF. In...
Cardiovascular diseases remain the Philippines' leading cause of mortality, with hypertension as a prevalent contributory risk factor. We took part in May Measurement Month 2017 (MMM17), global initiative to raise awareness high blood pressure (BP) and serve temporary solution lack screening programs worldwide. Following standard MMM protocol, data for 271 604 screened individuals were submitted from Philippines. After multiple imputation, 91 994 (34.3%) hypertensive; 28 662 out 205 158...
The presence of atrial natriuretic factor (ANF) in fetal tissues and plasma early gestation suggests that ANF may have a physiological role cardiocirculatory homeostasis utero. However, reported responsiveness the kidney to varies markedly. To characterize ontogeny renal ANF, chronically catheterized ovine fetuses at 114 +/- 1 days (n = 6) 131 received successive (30 min each) intravenous infusions rates 5, 25, 100 ng.min-1.kg-1. Mean (+/- SE) levels increased from 328 54 1,866 482 521 135...
Seasons can affect human inflammatory status and the occurrence of diseases, foods may also have differential impacts on inflammation across seasons; however, few studies investigated whether there are independent joint seasons red meat, fruit vegetable intakes in breast cancer survivors. We conducted a cross-sectional study by leveraging large cohort, Women’s Healthy Eating Living (WHEL) study. The WHEL comprised primarily early stage survivors collected blood samples, dietary intake,...