A5073538398- German Literature and Culture Studies
- Nietzsche, Schopenhauer, and Hegel
- Medieval and Classical Philosophy
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Religion, Theology, History, Judaism, Christianity
- Agricultural safety and regulations
- Effects and risks of endocrine disrupting chemicals
- Jewish and Middle Eastern Studies
- Chronic Lymphocytic Leukemia Research
- Psychoanalysis and Social Critique
- Art, Aesthetics, and Perception
- German legal, social, and political studies
- Walter Benjamin Studies Compilation
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Real-time simulation and control systems
- Environmental Toxicology and Ecotoxicology
- Diagnosis and Treatment of Venous Diseases
- Lung Cancer Treatments and Mutations
- Philosophy and Historical Thought
- German History and Society
- Electric Motor Design and Analysis
- Historical, Literary, and Cultural Studies
University of Potsdam
2023
Klinikum Dortmund
2023
German Environment Agency
2000-2022
Praxis für Hämatologie und Onkologie
2019-2020
Institut für Hämatopathologie Hamburg
2007-2018
Internationale Akademie Berlin
2015
Paderborn University
2010-2014
Environment Agency
2009-2011
Aptiv (United States)
2010
Pathologie Hamburg-West
2010
Multislice spiral computed tomography (MSCT) with retrospectively ECG-gated image reconstruction permits coronary artery visualization. We investigated the method's ability to identify high-grade stenoses and occlusions.A total of 64 consecutive patients were studied by MSCT (4x1 mm cross-sections, 500-ms rotation, table feed 1.5 mm/rotation, intravenous contrast agent, reconstruction). All arteries side branches a luminal diameter >/=2.0 assessed concerning evaluability presence (>70%...
Abstract In recent years, more and countries see irrigation using reclaimed water as an opportunity to secure enhance agricultural production. Despite the benefits of reuse, scientific community raised several concerns challenges for human health environment. This includes chemical risks. Effluents from urban wastewater treatment plants usually contain a wide range organic chemicals. Such chemicals remaining in after process may cause hazards health, contaminate surrounding soil resources,...
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic (PFOS) are the most investigated substances of group per- polyfluorinated chemicals (PFCs). Whereas for PFOS regulatory measures already in force on international level (inclusion Stockholm Convention Persistent Organic Pollutants) such activities missing PFOA. The environmental concerns PFOA, which summarized present study, underline necessity an Since it seems more likely to agree a regulation within European Union first, strategy...
Acute toxicity testing in fish is a standard method used estimating the influences of chemicals on aquatic vertebrates. The ecotoxicological data obtained from acute tests are, however, not sufficiently reliable to justify continued use this test. Fertilised eggs zebrafish ( Brachydanio rerio) were test chemicals. They chosen because development B. rerio has been studied extensively and information already exists concerning normal species. following parameters observed: coagulation egg,...
Case ReportWe treated a 51-year-old white man with classic hairy cell leukemia (HCL) who was-in contrast to most patients HCL-refractory multiple lines of conventional therapy. 1 In February 2009, the patient HCL presented splenomegaly, massive bone marrow infiltration, and worsening pancytopenia.He was 5-day course cladribine (0.14 mg/kg), which neither improved cytopenia nor reduced degree infiltration.In December 2010 disease progression, second-line therapy pentostatin (7 ϫ 4 mg/m 2...
The 5th cycle of the German Environmental Survey (GerES V) investigated internal human exposure children and adolescents aged 3–17 years in Germany to per- polyfluoroalkyl substances (PFAS). fieldwork population-representative GerES V was performed from 2014 2017. In total, 1109 blood plasma samples were analysed for 12 PFAS including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic (PFOA), perfluorohexane (PFHxS). PFOS quantified all PFOA almost samples, demonstrating ubiquitous...
This article summarizes discussions at the SETAC Pellston Workshop on "Science-Based Guidance and Framework for Evaluation Identification of PBTs POPs" provides an overview other articles from that workshop are also published in this issue. persistent, bioaccumulative, toxic substances (PBTs) persistent organic pollutants (POPs) evaluation their impact more complicated than those chemicals remain a challenge. The main reason is PBT substance POP assessment associated with higher uncertainty...
For the simulation of electrical drives, reduced-order models or simple look-up tables are often used in order to decrease computation time. In latter case, quality results is reduced due interpolation. This publication introduces a coupled structure which includes control, power electronics and also permanent magnet synchronous machine. Each these components simulated different software environments. The coupling between tools realized by defined data flow structure. Such can be useful for...
Keratinocytic epidermal nevus syndrome (KENS) is a complex disorder not only characterized by the presence of nevi but also abnormalities in internal organ systems. A small number cases with KENS are molecularly and reported literature somatic activating RAS, FGFR3 PIK3CA mutations.In this study we present patient hyper- hypopigmented regions, verrucous pigmented skin lesions paravertebral conglomerate tumour at level cervical thoracic spine. large lipomatous dumbbell caused atrophy spinal...
Summary We have shown that the thrombin G-protein coupled receptors (GPCR) designated as protease-activated (PAR-1) are expressed in primary cancer cells isolated from peritoneal and pleural malignant effusions. Here, our main goal was to evaluate several coagulation activation effectors markers a series of 136 effusions patients with gastrointestinal, lung mammary carcinomas. All these present highly activated system blood their effusions, indicated by high levels prothrombin F1.2 fragments...
One important purpose of the European REACH Regulation (EC No. 1907/2006) is to promote use alternative methods for assessment hazards substances in order avoid animal testing. Experience with environmental hazard under shows that efficient are needed assess chemicals when standard test data missing. such method weight-of-evidence (WoE) approach. In this study, WoE approach was used persistence certain phenolic benzotriazoles, a group including also very high concern (SVHC). For challenging...
Long term incidence of symptomatic venous thromboembolism (VTE) and bleeding events in patients with superficial vein thrombosis (SVT) was investigated.
Abstract Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. The role of an autologous tumor-specific immune control contributing to the length survival in CLL poorly understood. We investigated whether humoral immunity specific for CLL-associated Ag oncofetal Ag/immature laminin receptor (OFA/iLR) has prognostic value CLL. Among sera 67 untreated patients with CLL, 23 (34.3%) had detectable OFA/iLR Abs that were reactive at least one epitope. Patients...
The identification and regulation of substances that combine persistence, bioaccumulation potential, toxicity ("PBT" substances) is one central aspect the European chemical legislation REACH (Registration, Evaluation, Authorisation, Restriction Chemicals), because these may elicit adverse long-term effects after release to environment. determination a substance has based on set distinct cutoff criteria identified in Annex XIII regulation. Regarding evaluation focused substance's...
ObjectiveThe aim of this study was to assess the utilization surgical interventions in patients diagnosed with superficial vein thrombosis (SVT) and its potential association occurrence venous thromboembolism (VTE) bleeding events.MethodsINSIGHTS-SVT, a prospective, non-interventional, multicenter Germany, investigated management outcomes acute SVT who received conservative and/or invasive treatments at discretion treating physician.ResultsAmong 872 12-month data, 657 had medical therapy...
EGFR and its downstream signaling pathway are important targets for cancer therapy. Recently, the monoclonal anti-EGFR antibody Necitumumab in combination with gemcitabine cisplatin was approved (EMA/14106/2016) first-line treatment of squamous non-small cell carcinoma (SqNSCLC). Eligibility restricted to cases positive expression. In this context, a ring trial Quality Assurance Initiative Pathology (QuIP®) launched prepare German pathology community reliable reproducible,...