A5066171620- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Nutritional Studies and Diet
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Medicinal Plants and Neuroprotection
- Nutrition, Genetics, and Disease
- Diet, Metabolism, and Disease
- Nutrition and Health in Aging
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Dementia and Cognitive Impairment Research
- Epigenetics and DNA Methylation
- Medicinal Plants and Bioactive Compounds
- Consumer Attitudes and Food Labeling
- Birth, Development, and Health
- Child Nutrition and Feeding Issues
- Urinary Tract Infections Management
- Immune cells in cancer
- Esophageal and GI Pathology
- Amino Acid Enzymes and Metabolism
- Lipid metabolism and biosynthesis
Princeton University
2025
Iowa Soybean Association
2018-2023
University of Chicago
2011-2022
MB Clinical Research and Consulting (United States)
2016-2018
Crystal Technology and Industries (United States)
2014
Iowa State University
2004-2011
Integra (United States)
2011
Adipocytes are critical for ovarian cancer cells to home the omentum, but metabolic changes initiated by this interaction unknown. To end, we carried out unbiased mass spectrometry-based metabolomic and proteomic profiling of cocultured with primary human omental adipocytes. Cancer underwent significant proteo-metabolomic alteration(s), typified in lipidome corresponding upregulation lipid metabolism proteins. FABP4, a chaperone protein, was identified as regulator responses Subsequently,...
The present paper reports a complete mass spectrometric characterization of both the phenolic and volatile fractions dried spearmint extract. Phenolic compounds were analysed by ultra-high performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MSn) total 66 tentatively identified, being widest characterisation to date. analysis suggests that extract is composed rosmarinic acid its derivatives (230.5 ± 13.5 mg/g) with smaller amounts salvianolic acids,...
Objective: The purpose of this study was to investigate the effects supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood individuals age-associated memory impairment (AAMI). Design: Subjects AAMI (N = 90; 67% female; age 59.4 ± 0.6 years) were randomly assigned (n 30/group) consume 900, 600, or 0 mg/day (two capsules, once daily) extract for 90 days, double-blind, placebo-controlled trial....
Nutritional ketosis is a state of mildly elevated blood ketone concentrations resulting from dietary changes (e.g., fasting or reduced carbohydrate intake) exogenous consumption. In this study, we determined the tolerability and safety novel diester, bis-hexanoyl-(R)-1,3-butanediol (BH-BD), in 28-day, randomized, double-blind, placebo-controlled, parallel trial (NCT04707989). Healthy adults (n = 59, mean (SD), age: 42.8 (13.4) y, body mass index: 27.8 (3.9) kg/m2) were randomized to consume...
Personalized nutrition may be more effective in changing lifestyle behaviors compared to population-based guidelines. This single-arm exploratory study evaluated the impact of a 10-week personalized systems (PSN) program on behavior and health outcomes. Healthy men women (n = 82) completed trial. Individuals were grouped into seven diet types, for which phenotypic, genotypic behavioral data used generate recommendations. Behavior change guidance was also provided. The intervention reduced...
Previous studies have demonstrated that chronic supplementation with a proprietary spearmint extract (PSE) can improve cognitive performance in individuals 50-70 years of age age-related memory issues. In the present study, our hypothesis was PSE would young, active individuals. Using randomized, double-blind, placebo-controlled, parallel design, healthy, recreationally men and women (N = 142) received 900 mg or placebo (PLA) daily for 90 days. Cognition assessed via test battery (CNS Vital...
A diabetic state induces the activity and abundance of glycine N-methyltransferase (GNMT), a key protein in regulation folate, methyl group, homocysteine metabolism. Because folate-dependent one-carbon pool is source groups 5-methyltetrahydrofolate allosterically inhibits GNMT, aim this study was to determine whether folate status has an impact on interaction between diabetes group Rats were fed diet containing deficient (0 ppm), adequate (2 or supplemental (8 ppm) for 30 days, after which...